Participation, yield, and interval carcinomas in three rounds of biennial FIT-based colorectal cancer screening

Abstract

In an FIT-based screening program, participation rates remained stable over consecutive biennial screening rounds, while the FIT positivity rate and positive predictive value for advanced neoplasia gradually declined. Cancers in non-participants are significantly more advanced in staging than cancers in participants in the first round of screening.

Adherence to colorectal cancer screening: four rounds of faecal immunochemical test-based screening

“…Details about the design of our program have been described previously (van Rossum et al , 2008; Denters et al , 2013; Kapidiz et al , 2014; Stegeman et al , 2015). In short, demographic data of persons between 50 and 74 years living in the southwest and northwest of The Netherlands were obtained from municipal population registers.…”

A randomised comparison of two faecal immunochemical tests in population-based colorectal cancer screening

“…Details about the design of the ongoing population-based CRC screening pilot programme have been described previously 7 16 17 19 20. This trial was registered at http://www.trialregister.nl (identifier NTR5385).…”

Recommendations on fecal immunochemical testing to screen for colorectal neoplasia: a consensus statement by the US Multi-Society Task Force on colorectal cancer

“…Available data indicate that FIT participation rates tend to remain stable through multiple rounds of screening. [45][46][47][48][49][50][51][52] For example, after 3 rounds of programmatic screening in The Netherlands, participation among those eligible to be screened remained greater than 60%. 47 After 4 rounds of a biennial screening program in Italy, 1862 individuals received all 4 invitations to be screened.…”

“…Those initial responders who subsequently were eligible for screening and sent a kit continued to participate in the range of 75%-86% over the following 3 rounds. 52 Similar to screening with gFOBT, the positivity rate, subsequent demand for colonoscopy, detection rate, and PPV for CRC decreased with successive rounds of screening with FIT [45][46][47][48][49][50][51][52] (Table 3). However, the detection rate and PPV for advanced neoplasia (ie, the combined outcome of cancer and advanced adenomas) remained higher with repeated FIT than with repeated gFOBT.…”