The cashew processing industry plays a vital role in supporting the livelihoods of a large number of individuals in southern Kerala. Therefore, this study aimed to determine the prevalence of occupational health problems and associated factors among cashew workers. This cross-sectional survey was conducted among 360 cashew workers. Socio-demographics, musculoskeletal disorders (MSDs), respiratory symptoms, and dermatological problems were collected through a scheduled interview. Log binomial regression analysis was done. The prevalence of MSDs, chronic lung diseases (CLDs), and dermatological problems were 55.8%, 18.9%, and 47.5%, respectively. Female workers and workers with a lower education level were significantly more likely to report MSDs. Male workers and those with more years of employment were significantly more likely to report CLDs. Workers in the shelling and peeling section were significantly more likely to report dermatological problems. Targeted interventions to improve the occupational health of cashew workers are needed.