Particle control of emulsion by membrane emulsification and its applications

Nakashima, Tadao; Shimizu, Masataka; Kukizaki, Masato

doi:10.1016/s0169-409x(00)00099-5

Cited by 369 publications

(248 citation statements)

References 7 publications

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“…Several single-drop technologies have been developed for generating uniform droplets, such as injection of liquid through a capillary into another co-flowing immiscible fluid [3,4], penetration of dispersed phase through microfabricated parallel silicon channels [5] or interconnected channel network in microfluidic devices [6,7], and injection of dispersed phase through microporous membranes of different nature (glass, ceramic, metallic, polymeric) [8][9][10][11][12][13][14]. Production of various particulate products, such as microspheres and microcapsules, using membrane emulsification routes was recently reviewed by Vladisavljević and Williams [15].…”

Section: Introductionmentioning

confidence: 99%

“…In 'premix membrane emulsification' fine emulsions are produced by homogenization of coarsely emulsified feeds through the membrane [16]. In order to stimulate droplet detachment from the pore outlets in the direct emulsification, shear stress is generated at the membrane/continuous phase interface by recirculating the continuous phase through the membrane in cross flow [8] or by agitation in a stirring vessel [17]. Zhu et al [18] have intruduced membrane vibration, through piezoactuation, to help the detachment of droplets and provide an extra control over droplet detachment in crossflow membrane emulsification.…”

Section: Introductionmentioning

confidence: 99%

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Manufacture of large uniform droplets using rotating membrane emulsification

Vladisavljević

Williams

2006

Journal of Colloid and Interface Science

119

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A new rotating membrane emulsification system using a stainless steel membrane with 100 µm laser drilled pores was used to produce oil/water emulsions consisting of 2 wt. % Tween 20 as emulsifier, paraffin wax as dispersed oil phase and 0.01-0.25 wt. % Carbomer (Carbopol ETD 2050) as stabilizer. The membrane tube, 1 cm in diameter, was rotated inside a stationary glass cylinder, diameter of 3 cm, at a constant speed in the range 50-1500 rpm. The oil phase was introduced inside the membrane tube and permeated through the porous wall moving radially into the continuous phase in the form of individual droplets. Increasing the membrane rotational speed increased the wall shear stress which resulted in a smaller average droplet diameter being produced. For a constant rotational speed, the average droplet diameter increased as the stabilizer content in the continuous phase was lowered. The optimal conditions for producing uniform emulsion droplets were a Carbomer content of 0.1-0.25 wt. % and a membrane rotational speed of 350 rpm, under which the average droplet diameter was 105-107 µm and very narrow coefficients of variation of 4.8-4.9 %. A model describing the operation is described and it is concluded that the methodology holds potential as a manufacturing protocol for both coarse and fine droplets and capsules.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Manufacture of large uniform droplets using rotating membrane emulsification

Vladisavljević

Williams

2006

Journal of Colloid and Interface Science

119

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“…Shirasu is added as a source of SiO 2 and Al 2 O 3 , but since it is a natural material, it contains also small amounts of other components, such as Na 2 O, K 2 O, Fe 2 O 3 , etc [2]. After primary glass is formed into tube, it is subjected to heat treatment at a temperature of 650-750 °C for the periods ranging from several hours to tens of hours [2,3]. This treatment causes the homogeneous primary glass to transform into a heterogeneous two-phase glass consisting of Al 2 O 3 -SiO 2 and CaO-B 2 O 3 phases.…”

Section: Introductionmentioning

confidence: 99%

“…SPG finds many applications as a packing for HPLC columns, a carrier of enzymes and tissue cultures, an injection needle for blood transfusion and dialysis, and especially as a high-functional dispersion and separation membrane for preparing uniform droplets and micro-bubbles [3][4][5], microfiltration of oil-in-water (O/W) emulsions and suspensions [6][7][8], etc. The microstructure of SPG is of primary importance in any application.…”

Section: Introductionmentioning

confidence: 99%

Permeability of hydrophilic and hydrophobic Shirasu-porous-glass (SPG) membranes to pure liquids and its microstructure

Vladisavljević

Shimizu²,

Nakashima

2005

Journal of Membrane Science

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• This is the author's version of a work that was accepted for publication Hydrophobic modification of membrane surface was made by surface coating with silicone resin. The results are discussed using the non-uniform capillary bundle model of membrane permeability. The mean pore tortuosity of 1.28 was kept constant over the whole range of mean pore sizes investigated. The SEM images confirmed that the geometry of pore network was similar for all SPG membranes, irrespective of their mean pore size. The span of pore size distribution ranged from 0.28 to 0.68 and the number of pores per unit cross-sectional -2-membrane area from 10 9 to 10 13 m -2 . The membrane resistance was unchanged after surface treatment with silicone resin, which means that the pores were not plugged by the resin, even in the submicron range of mean pore sizes.

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“…Over the past decade microengineering techniques for the production of hydrogel microbeads have been developed, such as micromolding [12], photolithography [13], microfluidic routes [14][15][16], microchannel emulsification [17] and membrane emulsification [18][19]. These processes are illustrated schematically in Figure 1 and listed in Table 1 along with the examples of the beads fabricated.…”

Section: Introductionmentioning

confidence: 99%

Manufacture of chitosan microbeads using centrifugally driven flow of gel-forming solutions through a polymeric micronozzle

Mark

Haeberle

Zengerle

et al. 2009

Journal of Colloid and Interface Science

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A centrifugally driven pulse-free flow has been used for generation of tripolyphosphate (TPP)-gelated chitosan beads with tunable diameters ranging from 148 to 257 µm. The production process requires a single motor as the sole actively actuated component. The 2 % (w/w) chitosan solution was extruded through a polymeric nozzle with an inner diameter of 127 µm in the centrifugal field ranging from 93 to 452 g and the drops were collected in an Eppendorf tube containing 10 % (w/w) TPP solution at pH 4.0. The reproducibility of the bead diameters out of different nozzles was very good with overall CVs of the bead diameters down to 15 % and the production rate was 45 beads per second per nozzle at 44 Hz rotor frequency. The production rate was proportional to the sixth power of the rotor frequency, which was explained by the non-Newtonian behaviour of the chitosan solution with a flow behaviour index of 0.466. An analytical model for the bead diameter and production rate has been presented and validated by the experimental data. The shrinkage of chitosan drops during gelation was estimated from the observations and the theoretical model. 2

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Particle control of emulsion by membrane emulsification and its applications

Cited by 369 publications

References 7 publications

Manufacture of large uniform droplets using rotating membrane emulsification

Manufacture of large uniform droplets using rotating membrane emulsification

Permeability of hydrophilic and hydrophobic Shirasu-porous-glass (SPG) membranes to pure liquids and its microstructure

Manufacture of chitosan microbeads using centrifugally driven flow of gel-forming solutions through a polymeric micronozzle

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