Landauer's principle has seen a boom of interest in the last few years due to the growing interest in quantum information sciences. However, its relevance and validity in the contexts of quantum field theory (QFT) remain surprisingly unexplored. In this Letter, we consider Landauer's principle in qubit-cavity QFT interaction perturbatively, in which the initial state of the cavity QFT is chosen to be vacuum or thermal state. In the vacuum case, the QFT always absorbs heat and jumps to excited states. For the qubit at rest, its entropy decreases; whereas if the qubit accelerates, it may also gain energy and increases its entropy due to Unruh effect. For the thermal state, the QFT can both absorb and release heat, depending on its temperature and the initial state of the qubit, and the higher order perturbations can excite/de-excite the initial state to higher/lower state. Landauer's principle is valid in all the cases we consider. We hope that this study could pave a way for future explorations of Landauer's principle in QFT and gravity theories.