Particle-induced osteolysis mediated by endoplasmic reticulum stress in prosthesis loosening

Wang, Rui; Wang, Zhenheng; Ma, Yu; Liu, Guoyin; Shi, Hao; Chen, Jiangning; Dong, Lei; Zhao, Jianning; Zhang, Junfeng

doi:10.1016/j.biomaterials.2013.01.025

Cited by 42 publications

(75 citation statements)

References 54 publications

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“…Based on previous studies concerning inflammatory cytokines and bone metabolism and the observation that both TiPs and CoPs were able to stimulate the production of TNF-α and IL-1β in this study, it was reasonable to speculate that TNF-α and IL-1β, produced by macrophages after the stimulation of metal nanoparticles, mediated the balance between bone resorption and formation in the pathological process of aseptic loosening ( Figure S2). 4,[34][35][36][37][38][39] SIRT1 is an important HDAC due to its proposed role in the association between calorie restriction and lifespan extension. SIRT1 is also a major regulator of bone mass.…”

Section: Discussionmentioning

confidence: 99%

“…1 Among various nanoparticles generated from implant components, metal particles, such as TiAl6V4 particles (TiPs) and CoCrMo particles (CoPs), are among the most common materials to be studied due to the wide use of metal prostheses in clinical practice. 2 Briefly, nanoparticles generated from implant components stimulate local macrophages and mesenchymal cells to release a multitude of cytokines, chemokines, and metalloproteinases, 3,4 which subsequently activate osteoclasts and result in bone resorption. 5 Furthermore, inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin (IL)-1β, modulate the balance between osteoblast and osteoclast activities and promote osteolysis.…”

Section: Introductionmentioning

confidence: 99%

“…10 Endoplasmic reticulum (ER) stress is a mediator in the inflammatory responses induced by both TiPs and CoPs in osteolysis. 4 However, a specific target for the effective…”

Section: Introductionmentioning

confidence: 99%

“…Using an ER stress inhibitor, the inflammatory response and osteolysis could be ameliorated both in vitro and in vivo. 4 However, the precise mechanisms underlying the induction of ER stress by TiPs and CoPs in macrophages remain unclear. Interestingly, multiple correlations between SIRT1 and ER stress have been reported ( Figure S3A).…”

mentioning

confidence: 99%

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The metal nanoparticle-induced inflammatory response is regulated by SIRT1 through NF-κB deacetylation in aseptic loosening

Deng¹,

Jin²,

Wang³

et al. 2017

IJN

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Aseptic loosening is the most common cause of total hip arthroplasty (THA) failure, and osteolysis induced by wear particles plays a major role in aseptic loosening. Various pathways in multiple cell types contribute to the pathogenesis of osteolysis, but the role of Sirtuin 1 (SIRT1), which can regulate inflammatory responses through its deacetylation, has never been investigated. We hypothesized that the downregulation of SIRT1 in macrophages induced by metal nanoparticles was one of the reasons for osteolysis in THA failure. In this study, the expression of SIRT1 was examined in macrophages stimulated with metal nanoparticles from materials used in prosthetics and in specimens from patients suffering from aseptic loosening. To address whether SIRT1 downregulation triggers these inflammatory responses, the effects of the SIRT1 activator resveratrol on the expression of inflammatory cytokines in metal nanoparticle-stimulated macrophages were tested. The results demonstrated that SIRT1 expression was significantly downregulated in metal nanoparticle-stimulated macrophages and clinical specimens of prosthesis loosening. Pharmacological activation of SIRT1 dramatically reduced the particle-induced expression of inflammatory cytokines in vitro and osteolysis in vivo. Furthermore, SIRT1 regulated particle-induced inflammatory responses through nuclear factor kappa B (NF-κB) acetylation. Thus, the results of this study suggest that SIRT1 plays a key role in metal nanoparticle-induced inflammatory responses and that targeting the SIRT1 pathway may lead to novel therapeutic approaches for the treatment of aseptic prosthesis loosening.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…10 Endoplasmic reticulum (ER) stress is a mediator in the inflammatory responses induced by both TiPs and CoPs in osteolysis. 4 However, a specific target for the effective…”

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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The metal nanoparticle-induced inflammatory response is regulated by SIRT1 through NF-κB deacetylation in aseptic loosening

Deng¹,

Jin²,

Wang³

et al. 2017

IJN

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“…[1][2][3] However, wear particle-induced osteolysis and the subsequent aseptic loosening remain the most common causes of arthroplasty failure and revision surgery in the med-to long term. 4 Wear debris that is generated from implant components plays a key role in aseptic loosening.…”

Section: Introductionmentioning

confidence: 99%

Probiotics protect mice from CoCrMo particles-induced osteolysis

Wang¹,

Xue²,

Bai³

et al. 2017

IJN

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Wear particle-induced inflammatory osteolysis is the primary cause of aseptic loosening, which is the most common reason for total hip arthroplasty (THA) failure in the med- and long term. Recent studies have suggested an important role of gut microbiota (GM) in modulating the host metabolism and immune system, leading to alterations in bone mass. Probiotic bacteria administered in adequate amounts can alter the composition of GM and confer health benefits to the host. Given the inflammatory osteolysis that occurs in wear debris-induced prosthesis loosening, we examined whether the probiotic Lactobacillus casei could reduce osteolysis in a mouse calvarial resorption model. In this study, L. casei markedly protected mice from CoCrMo particles (CoPs)-induced osteolysis. Osteoclast gene markers and the number of osteoclasts were significantly decreased in L. casei -treated mice. Probiotic treatment decreased the M1-like macrophage phenotype indicated by downregulation of tumor necrosis factor α (TNF-α), interleukin (IL)-6 and inducible nitric oxide synthase (iNOS) and increased the M2-like macrophage phenotype indicated by upregulation of IL-4, IL-10 and arginase. Collectively, these results indicated that the L. casei treatment modulated the immune status and suppressed wear particle-induced osteolysis in vivo. Thus, probiotic treatment may represent a potential preventive and therapeutic approach to reduced wear debris-induced osteolysis.

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Protective effect of zinc supplementation on tricalcium phosphate particles‐induced inflammatory osteolysis in mice

Yang

Zhang

Zhu

et al. 2022

Microscopy Res & Technique

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Zinc (Zn), an essential trace element, can stimulate bone formation and inhibit osteoclastic bone resorption, which controls the growth and maintenance of bone. However, the effect of Zn supplementation on tricalcium phosphate (TCP) wear particles‐induced osteolysis remains unknown. Here, we doped Zn into TCP particles (ZnTCP), and explore the protective effects of Zn on TCP particles‐induced osteolysis in vivo. TCP particles and ZnTCP particles were embedded under the periosteum around the middle suture of the mouse calvaria. After 2 weeks, blood, the periosteal tissue, and the calvaria were collected to determine serum levels of Zn and osteocalcin, pro‐inflammatory cytokines, bone biochemical markers, osteoclastogenesis and bone resorption area, and to explain its mechanism. Data revealed that Zn significantly prevented TCP particles‐induced osteoclastogenesis and bone loss, and increased bone turnover. The Zn supplement remarkably suppressed the release of pro‐inflammatory cytokines including tumor necrosis factor (TNF)‐α, interleukin (IL)‐1β, and IL‐6. Immunoblotting demonstrated that Zn alleviated expression levels of ER stress‐related proteins such as glucose‐regulated protein 78 (GRP78), PKR‐like ER kinase (PERK), phospho‐PERK (p‐PERK), eukaryotic initiation factor 2α (eIF2α), phospho‐eIF2α (p‐eIF2α), activating transcription factor 4 (ATF4), inositol‐requiring enzyme 1α (IRE1‐α) and transcription factor X‐box binding protein spliced (XBP1s), leading to decreasing the ratios of p‐PERK/PERK and p‐eIF2α/eIF2α. Taken together, Zn supplementation strongly prevents TCP particles‐induced periprosthetic osteolysis via inhibition of the ER stress pathway, and it may be a novel therapeutic approach for the treatment of aseptic prosthesis loosening.

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Particle-induced osteolysis mediated by endoplasmic reticulum stress in prosthesis loosening

Cited by 42 publications

References 54 publications

The metal nanoparticle-induced inflammatory response is regulated by SIRT1 through NF-κB deacetylation in aseptic loosening

The metal nanoparticle-induced inflammatory response is regulated by SIRT1 through NF-κB deacetylation in aseptic loosening

Probiotics protect mice from CoCrMo particles-induced osteolysis

Protective effect of zinc supplementation on tricalcium phosphate particles‐induced inflammatory osteolysis in mice

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Particle-induced osteolysis mediated by endoplasmic reticulum stress in prosthesis loosening

Cited by 42 publications

References 54 publications

The metal nanoparticle-induced inflammatory response is regulated by SIRT1 through NF-&kappa;B deacetylation in aseptic loosening

The metal nanoparticle-induced inflammatory response is regulated by SIRT1 through NF-&kappa;B deacetylation in aseptic loosening

Probiotics protect mice from CoCrMo particles-induced osteolysis

Protective effect of zinc supplementation on tricalcium phosphate particles‐induced inflammatory osteolysis in mice

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The metal nanoparticle-induced inflammatory response is regulated by SIRT1 through NF-κB deacetylation in aseptic loosening

The metal nanoparticle-induced inflammatory response is regulated by SIRT1 through NF-κB deacetylation in aseptic loosening