This article presents a discussion on three major types of two/three‐phase reactors: bubble column or two/three‐phase sparged reactor, stirred reactor, and venturi loop reactor. The aim is to provide appropriate process design philosophy. The basics of mass transfer accompanied by a chemical reaction are initially presented followed by experimental methods used for discerning reaction kinetics of a multiphase reaction. Metrics for reactor selection have been outlined. A simplified design philosophy that is based on identification of the rate‐controlling step and the associated rate equation has been presented. The intrinsic reaction kinetics do not vary with the type/size of the reactors used. Therefore, the problem reduces to prediction of reactor type and size‐dependent mass transfer coefficients.
Subsequent discussion deals with individual reactors with respect to (i) advantages/drawbacks, (ii) areas of application, (iii) hydrodynamic regimes, (iv) gas‐phase holdup, (v) gas–liquid and solid–liquid mass transfer coefficients,
k
L
a
and
K
SL
, respectively. The focus is on presenting reliable correlations for
k
L
a
and
K
SL
that allow estimation of the rates of corresponding mass transfer steps. Comparison of these with the intrinsic reaction rate yields the rate‐controlling step and associated rate expression for reactor design. The article concludes with a comparison of the performance of the three types chosen for discussion. For the specific reaction chosen, it is concluded that the venturi loop system yields superior performance.