Particle manipulation using 3D ac electro-osmotic micropumps

Hilber, Wolfgang; Weiß, Bernhard; Mikolášek, Miroslav; Holly, Roman; Hingerl, Kurt; Jakoby, Bernhard

doi:10.1088/0960-1317/18/6/064016

Cited by 13 publications

(19 citation statements)

References 16 publications

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“…The particle front traversed towards the center of the chip, similarly to the on-chip collection device by Bhatt et al, 26 but at much faster rate. Note that the velocities reported here are not the bulk fluid flow velocities as reported in previous ACEO pumping literature, [17][18][19][20][21][22][23][24] but are the rate of motion of the particle front.…”

Section: Resultsmentioning

confidence: 84%

“…[15][16][17][18][19][20][21][22][23][24]26,27 (see Supplementary Material for design considerations 29 ). The microelectrode devices were fabricated by Research Triangle Institute International using a single mask layer on 4 in., 700 lm thick borofloat glass wafers by a standard photolithographic lift-off process.…”

Section: B Electrode Chip Fabricationmentioning

confidence: 99%

“…The particle motion increased as the potential was increased as predicted by previous ACEO asymmetrical electrode pumping studies. [17][18][19][20][21][22][23] However, no combination of low potential (250 mV-1 V) or frequency (10 Hz-5 kHz) produced a unidirectional bulk fluid flow that would achieve the desired densely packed formation of particles in the center of the chip. For the 1600 lm chamber height, a particle front initially formed at the electrode edge within seconds of applying the electric field.…”

Section: Chamber Heightmentioning

confidence: 99%

“…14 Asymmetric electrode patterns have been shown to produce flows that can be used for microfluidic pumping. [15][16][17][18][19][20][21][22][23][24] Electrodes can be arranged on a substrate surface in such a way as to induce asymmetric electric field gradients at the electrodes, thereby generating a local and bulk liquid flow. The asymmetric field creates a vortex near the edge of the electrode, driving a bulk flow analogous to a conveyor belt.…”

Section: Introductionmentioning

confidence: 99%

“…At applied potentials from 0.1 to 10 V, planar asymmetric electrodes have been used to produce flows that are capable of transporting particles. [17][18][19]21,22,25 In this paper, we introduce a lTAS device using ACEO flow induced by co-planar asymmetric electrodes arranged in a "corral" configuration, exploited not only for pumping the liquid but for collecting particles in a target location on the device. Previously in our group, an ACEO corral device was used to collect particles and cells in the center of an energized electrode surrounded by a dielectric layer of an insulative photoresist.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

On-chip collection of particles and cells by AC electroosmotic pumping and dielectrophoresis using asymmetric microelectrodes

Melvin¹,

Moore²,

Gilchrist³

et al. 2011

Biomicrofluidics

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The recent development of microfluidic "lab on a chip" devices requiring sample sizes <100 lL has given rise to the need to concentrate dilute samples and trap analytes, especially for surface-based detection techniques. We demonstrate a particle collection device capable of concentrating micron-sized particles in a predetermined area by combining AC electroosmosis (ACEO) and dielectrophoresis (DEP). The planar asymmetric electrode pattern uses ACEO pumping to induce equal, quadrilateral flow directed towards a stagnant region in the center of the device. A number of system parameters affecting particle collection efficiency were investigated including electrode and gap width, chamber height, applied potential and frequency, and number of repeating electrode pairs and electrode geometry. The robustness of the on-chip collection design was evaluated against varying electrolyte concentrations, particle types, and particle sizes. These devices are amenable to integration with a variety of detection techniques such as optical evanescent waveguide sensing.

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Section: Resultsmentioning

confidence: 84%

Section: B Electrode Chip Fabricationmentioning

confidence: 99%

Section: Chamber Heightmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

On-chip collection of particles and cells by AC electroosmotic pumping and dielectrophoresis using asymmetric microelectrodes

Melvin¹,

Moore²,

Gilchrist³

et al. 2011

Biomicrofluidics

View full text Add to dashboard Cite

show abstract

Particle separation in alternating-current electro-osmotic micropumps using field-flow fractionation

Weiß

Hilber

Gittler

et al. 2008

Microfluid Nanofluid

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This work presents a novel method for continuous particle separation on the microscale by means of field-flow fractionation. It is based on the use of asymmetric interdigitated electrode arrays on the channel bottom, which induce an electro-osmotic channel flow when driven harmonically. Suspended particles are influenced by viscous fluid drag, sedimentation as well as by dielectrophoretic repulsion forces from the driving electrodes due to the emerging electric field. The significant dependance of the present forces on particle properties allows for separation with respect to particle density and size. This work analyzes electric and flow field by means of the finite element method and investigates the size and density dependent particle motion as a function of driving voltage and frequency of the electrode array. Matching these driving parameters permits the separation of sedimenting particles by their density independently from their size as well as the separation by size. Finally, channel designs are proposed which enable standard separation by means of selective particle mobility in the channel, separation in terms of opposing motion directions, as well as continuous lateral separation.

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Configurable AC electroosmotic generated in-plane microvortices and pumping flow in microchannels

Huang

Hsueh

Hung

2009

Microfluid Nanofluid

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This paper proposes the patterned AC electroosmotic flows (AC-EOF) by simply grouping discrete electrodes together to form various electrode configurations for generation of in-plane microvortices with clockwise/counter-clockwise rotation, and pumping flow in a microchannel. The rotational direction of in-plane microvortices and pumping flow direction can be controlled using the same electrode pattern by simple switching of the voltages on the electrodes. Microparticle image velocimetry (lPIV) was used to characterize the flow fields of the generated in-plane microvortices and pumping flow. The rotational strength of microvortices and flow rates of pumping flows were found to increase with the increase of the applied voltages, and an optimal value was achieved at an appropriately applied frequency. Moreover, the dependency of the applied voltages, frequencies, and the heights of the measured planes on the rotational strength of inplane microvortices between the interdigitated and discrete electrode configurations were examined. The discrepancy in electrode geometry results in a small performance reduction, whereas it can be compensated for the ability of switching the rotational direction of in-plane microvortices using the same device. The configurable in-plane microvortices and pumping flow in microchannels provide the potential for micromixing applications and for the integration into a lab-on-a-chip system.

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Particle manipulation using 3D ac electro-osmotic micropumps

Cited by 13 publications

References 16 publications

On-chip collection of particles and cells by AC electroosmotic pumping and dielectrophoresis using asymmetric microelectrodes

On-chip collection of particles and cells by AC electroosmotic pumping and dielectrophoresis using asymmetric microelectrodes

Particle separation in alternating-current electro-osmotic micropumps using field-flow fractionation

Configurable AC electroosmotic generated in-plane microvortices and pumping flow in microchannels

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