Particle morphology and antimicrobial properties of electrosprayed propolis

Atik, Didem Sözeri; Bölük, Esra; Bildik, Fatih; Altay, Filiz; Torlak, Emrah; Kaplan, Abdülkerim Ahmet; Kopuk, Berkay; Palabıyık, İbrahim

doi:10.1016/j.fpsl.2022.100881

Cited by 6 publications

(3 citation statements)

References 46 publications

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“…7 . Although, PE exhibited antimicrobial potential against all of the studied microorganisms, it has no influence on S. typhimurium as reported by Atik et al 44 . Control CNF/PVA hydrogel has no effect against the studied microorganisms.…”

Section: Resultssupporting

confidence: 60%

Egyptian propolis extract for functionalization of cellulose nanofiber/poly(vinyl alcohol) porous hydrogel along with characterization and biological applications

Saleh

Salama

Ali

et al. 2023

Sci Rep

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Bee propolis is one of the most common natural extracts and has gained significant interest in biomedicine due to its high content of phenolic acids and flavonoids, which are responsible for the antioxidant activity of natural products. The present study report that the propolis extract (PE) was produced by ethanol in the surrounding environment. The obtained PE was added at different concentrations to cellulose nanofiber (CNF)/poly(vinyl alcohol) (PVA), and subjected to freezing thawing and freeze drying methods to develop porous bioactive matrices. Scanning electron microscope (SEM) observations displayed that the prepared samples had an interconnected porous structure with pore sizes in the range of 10–100 μm. The high performance liquid chromatography (HPLC) results of PE showed around 18 polyphenol compounds, with the highest amounts of hesperetin (183.7 µg/mL), chlorogenic acid (96.9 µg/mL) and caffeic acid (90.2 µg/mL). The antibacterial activity results indicated that both PE and PE-functionalized hydrogels exhibited a potential antimicrobial effects against Escherichia coli, Salmonella typhimurium, Streptococcus mutans, and Candida albicans. The in vitro test cell culture experiments indicated that the cells on the PE-functionalized hydrogels had the greatest viability, adhesion, and spreading of cells. Altogether, these data highlight the interesting effect of propolis bio-functionalization to enhance the biological features of CNF/PVA hydrogel as a functional matrix for biomedical applications.

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Section: Resultssupporting

confidence: 60%

Egyptian propolis extract for functionalization of cellulose nanofiber/poly(vinyl alcohol) porous hydrogel along with characterization and biological applications

Saleh

Salama

Ali

et al. 2023

Sci Rep

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“…Its composition varies according to the honeybees' food source and may contain more than 300 components [16]. Cheap and easy to find, its extract has antioxidant, anti-inflammatory, anti-microbial, and healing properties due to the presence of phenolic compounds and flavonoids in its composition [7,[17][18][19][20]. In an ideal concentration, propolis has the potential for skin repair aid and contributes to restraint pathogens.…”

Section: Introductionmentioning

confidence: 99%

Nanostructured Electrospun Polycaprolactone—Propolis Mats Composed of Different Morphologies for Potential Use in Wound Healing

et al. 2022

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This study aimed to investigate different types of morphologies obtained using the electrospinning process to produce a material that enables wound healing while performing a controlled release. Using benign solvents, the authors prepared and characterised electrospun polycaprolactone mats loaded with propolis, a popular extract in traditional medicine with potential for skin repair. Different morphologies were obtained from distinct storage periods of the solution before electrospinning to investigate the effect of PCL hydrolysis (average diameters of fibres and beads: 159.2–280.5 nm and 1.9–5.6 μm, respectively). Phytochemical and FTIR analyses of the extract confirmed propolis composition. GPC and viscosity analyses showed a decrease in polymer molecular weight over the storage period (about a 70% reduction over 14 days) and confirmed that it was responsible for the nanostructure diversity. Moreover, propolis acted as a lubricant agent, affecting the spun solutions’ viscosity and the thermal properties and hydrophilicity of the mats. All samples were within the value range of the water vapour transpiration rate of the commercial products (1263.08 to 2179.84 g/m2.day). Even though the presence of beads did not affect the propolis release pattern, an in vitro wound-healing assay showed that propolis-loaded mats composed of beaded fibres increased the cell migration process. Thus, these films could present the potential for use in wound dressing applications.

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“…Although it has unique beneficial health effects, its use in its original form is limited due to its low solubility in water and organic solvents and its strong flavour [ 11 ]. To date, several fabrication techniques such as spray-drying [ 12 , 13 ], electrospinning [ 11 ], complex-coacervation [ 14 ], electrospraying [ 15 ], and pressurized carbon dioxide anti-solvent crystallization [ 16 ] have been used for propolis encapsulation to overcome solubility problems. To the best of our knowledge, no published papers have focused on the encapsulation of propolis into the PVA by the electrospraying method.…”

Section: Introductionmentioning

confidence: 99%

Polyvinyl alcohol nanoparticles loaded with propolis extract: Fabrication, characterization and antimicrobial activity

Subaşı-Zarbaliyev,

Kutlu,

Törnük

2023

ADMET DMPK

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Background and Purpose: Propolis has high potential beneficial bioactive properties such as anti-oxidative, antimicrobial, and anti-tumour activities. However, the bitter taste and the insolubility nature of propolis in water lead to some limitations in their usage in functional food applications. Experimental Approach: Herein, we evaluated the effects of nanoencapsulation of propolis at the different concentration levels (0, 0.4, 0.8, 1.0, and 1.2 %) into the polyvinyl alcohol (PVA) nanoparticles using the electrospraying method, on the structural, physical, antioxidant, antimicrobial and thermal properties. Key Results: The results revealed that the fabricated nanocapsules (PVA-NPs) obtained under optimal conditions had uniform size distribution and unstable particles with small particle size between 104-258 nm, a polydispersity index <0.317, and a zeta potential between -5 and +5 mV. The maximum encapsulation efficiency of PVA-NPs was about 25.32 % for 1 % of the initial propolis loading level. DSC thermal experiments showed an increase in the thermal stability of the propolis loaded PVA nanoparticles as compared to the neat PVA nanoparticles. The percent inhibition of DPPH radical scavenging activity of the nanocapsules was between 80 and 89 %. SEM analysis revealed that PVA-NPs had a spherical shape with a rough surface and were composed of long and thin fibres at nanometric diameters. FT-IR analysis showed that no indications of any chemical reactions were found between the constituents of the core and wall material due to their physical mixing. Antibacterial efficacy was evaluated by the Broth dilution method and PVA-NPs exhibited good inhibitory activity against S. aureus at low concentration ratios, whereas it had no inhibitory activity against E. coli O157:H7. Conclusion: PVA-NPs fabricated using the electrospraying technique can be used for the development of a new promising natural and bioactive agent in the food and pharmaceutical industry.

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Particle morphology and antimicrobial properties of electrosprayed propolis

Cited by 6 publications

References 46 publications

Egyptian propolis extract for functionalization of cellulose nanofiber/poly(vinyl alcohol) porous hydrogel along with characterization and biological applications

Egyptian propolis extract for functionalization of cellulose nanofiber/poly(vinyl alcohol) porous hydrogel along with characterization and biological applications

Nanostructured Electrospun Polycaprolactone—Propolis Mats Composed of Different Morphologies for Potential Use in Wound Healing

Polyvinyl alcohol nanoparticles loaded with propolis extract: Fabrication, characterization and antimicrobial activity

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