Particle release from dental implants immediately after placement – An ex vivo comparison of different implant systems

Barrak, Fadi; Li, Siwei; Muntane, Albert; Bhatia, Manoj; Crossthwaite, Kathryn; Jones, Julian R.

doi:10.1016/j.dental.2022.04.003

Cited by 19 publications

(25 citation statements)

References 52 publications

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“…Further, internalization of Ti debris was evident in human gingival fibroblasts and RAW 264.7 macrophages for all the tested systems in vitro. [32] In another in vitro study, Ti-particles isolated from implant surfaces were applied to oral epithelial cells in culture to investigate molecular reactions of these cells. The findings revealed that DNA damage response was triggered by the interaction with Ti particles, suggesting a possible disruption of epithelial hemostasis and potential impairment of the epithelial barrier.…”

Section: In Vitro and Preclinical Studiesmentioning

confidence: 99%

“…A recent ex vivo study with porcine mandibles investigated the release of Ti particles during implant placement and the presence of particles inside the cells in the surrounding tissues. [ 32 ] The authors demonstrated significant differences in the number of particles released based on the design, surfaces and chemical composition of the implants. However, all the tested implant systems (Straumann ® and BioHorizons ® ) were shown to release Ti particles during implant insertion.…”

Section: Effect Of Titanium Particles and Ions On The Cellular Respon...mentioning

confidence: 99%

“…Further, internalization of Ti debris was evident in human gingival fibroblasts and RAW 264.7 macrophages for all the tested systems in vitro . [ 32 ]…”

Section: Effect Of Titanium Particles and Ions On The Cellular Respon...mentioning

confidence: 99%

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The Role of Titanium Particles and Ions in the Pathogenesis of Peri-Implantitis

2022

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Titanium (Ti) particles and ions have been investigated in recent years as important factors in the pathogenesis of peri-implantitis. However, their role in the pathogenesis is yet to be fully understood. A review of pertinent literature was performed in various databases to determine the current position of Ti particles and ions role in the pathogenesis of peri-implantitis. There are several <i>in vitro</i>, preclinical and clinical published studies that have addressed the role of Ti particles and ions in the pathogenesis of peri-implantitis. These studies explored the effect of Ti particles and ions in the pathogenesis of peri-implantitis with respect to foreign body reaction, cellular response, epigenetic mechanisms, namely DNA methylation, and the oral microbiome. Studies have shown that the release of Ti particles/ions during implant insertion, early healing stages, late healing stages, and treatments during peri-implantitis might contribute to peri-implantitis through different mechanisms, such as foreign body reaction, cellular response, DNA methylation, and shaping the oral microbiome by increasing dysbiosis. However, further studies are needed to elucidate the complex interactions between all these mechanisms and Ti particles/ions in the pathogenesis and progression of peri-implantitis.

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Section: In Vitro and Preclinical Studiesmentioning

confidence: 99%

Section: Effect Of Titanium Particles and Ions On The Cellular Respon...mentioning

confidence: 99%

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The Role of Titanium Particles and Ions in the Pathogenesis of Peri-Implantitis

2022

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“…According to Barrak et al [ 15 ], although titanium-based prostheses are considered non-toxic, the same may not be true with particles and ions released from them. Consequently, the potential cytotoxicity of Ti-6Al-4V implant particles should be highlighted, and more investigations on the biological effect of the fine particles or metallic species released are needed.…”

Section: Introductionmentioning

confidence: 99%

“…This standpoint is corroborated by Kunrath et al [ 12 ], who considered the long-term behavior of fragments of certain chemical elements in tissues or cells at the molecular level and indicated that this is still not well-understood. Ion release from metallic prosthetic devices is a current issue and the object of many recent studies [ 11 , 13 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Diffusion of Vanadium Ions in Artificial Saliva and Its Elimination from the Oral Cavity by Pharmacological Compounds Present in Mouthwashes

et al. 2022

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In this study, diffusion coefficients of ammonium vanadate at tracer concentrations in artificial saliva with and without sodium fluoride, at different pH values, were measured using an experimental model based on the Taylor dispersion technique. Ternary mutual diffusion coefficients (D11, D22, D12, and D21) for four aqueous systems {NH4VO3 (component 1) + β-cyclodextrin (β-CD) (component 2),} {NH4VO3 (component 1) + β-cyclodextrin (HP-β-CD) (component 2)}, {NH4VO3 (component 1) + sodium dodecyl sulphate (SDS) (component 2)} and {NH4VO3 (component 1) + sodium hyaluronate (NaHy) (component 2)} at 25.00 °C were also measured by using the same technique. These data showed that diffusion of ammonium vanadate was strongly affected in all aqueous media studied. Furthermore, a significant coupled diffusion of this salt and β-CD was observed through the non-zero values of the cross-diffusion coefficients, D12, allowing us to conclude that there is a strong interaction between these two components. This finding is very promising considering the removal, from the oral cavity, of vanadium resulting from tribocorrosion of Ti-6Al-4V prosthetic devices.

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Ion release and local effects of titanium metal particles from dental implants: An experimental study in rats

Toledano‐Serrabona

Camps‐Font

Moraes

et al. 2022

Journal of Periodontology

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Background The objective of this study was to evaluate the accumulation of ions in blood and organs caused by titanium (Ti) metal particles in a mandibular defect in rats, together with a description of the local reaction of oral tissues to this Ti alloy debris. Methods Twenty Sprague‐Dawley rats were randomly distributed into three groups: an experimental group with a mandibular bone defect filled with metallic debris obtained by implantoplasty; a positive control group; and a negative control group. Thirty days after surgery, the rats were euthanized and perilesional tissue surrounding the mandibular defect was removed, together with the lungs, spleen, liver, and brain. Two blood samples were collected: immediately before surgery and before euthanasia. The perilesional tissue was histologically analyzed using hematoxylin‐eosin staining, and Ti, aluminum, and vanadium ion concentrations in blood and organs were measured by TQ‐ICP‐MS. Descriptive and bivariate analyses of the data were performed. Results All rats with implanted metal debris showed metal particles and a bone fracture callus on the osseous defect. The metal particles were surrounded by a foreign body reaction characterized by the presence of histiocytes and multinucleated giant cells (MNGCs). The experimental group had a significant higher concentration of Ti ions in all studied organs except lung tissue (p < 0.05). In addition, there were more V ions in the brain in the experimental group (p = 0.008). Conclusions Although further studies are required to confirm the clinical relevance of these results, Ti metal particles in the jaw might increase the concentration of metal ions in vital organs and induce a foreign body reaction.

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Particle release from dental implants immediately after placement – An ex vivo comparison of different implant systems

Cited by 19 publications

References 52 publications

The Role of Titanium Particles and Ions in the Pathogenesis of Peri-Implantitis

The Role of Titanium Particles and Ions in the Pathogenesis of Peri-Implantitis

Diffusion of Vanadium Ions in Artificial Saliva and Its Elimination from the Oral Cavity by Pharmacological Compounds Present in Mouthwashes

Ion release and local effects of titanium metal particles from dental implants: An experimental study in rats

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