Particle Separation Using Dielectrophoresis

Kadaksham, J.; Singh, Pushpendra; Aubry, Nadine

doi:10.1115/imece2003-43950

Cited by 3 publications

(6 citation statements)

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“…(2) where r ij is the unit vector in the direction from the center of i-th particle to the center of j-th particle [22].…”

mentioning

confidence: 99%

“…The ratio of F D and F DEP is obtained from expressions (1) and (2) [10,22,23]. It is then rescaled by using the characteristic electric field strength, E 0 , the gradient of the electric field squared, E 2 0 /L, the distance between the particles, R, and the gap between the electrodes, L. This gives…”

mentioning

confidence: 99%

“…The computational domain in our finite element code is discretized using a body-fitted tetrahedral mesh. The resulting linear system of equations is solved using a multigrid preconditioned conjugate gradient method [22].…”

mentioning

confidence: 99%

“…The particle is at (0.4, 0.5, 0.55) and a = 0.15. The second particle is at (0.4+R, 0.5, 0.55) and εc = 1.0. chosen here, that could be used is to perform direct simulations of the particles trajectories to determine whether or not they cluster [22][23][24][25].…”

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confidence: 99%

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Control of electrostatic particle-particle interactions in dielectrophoresis

Aubry¹,

Singh²

2006

Europhys. Lett.

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In a nonuniform electric field, the particles of a suspension experience both a dielectrophoretic (DEP) force and electrostatic particle-particle forces. In applications which require that the particles be manipulated individually the latter forces are not desirable. It is shown numerically that the ratio of the particle-particle and DEP forces decreases with increasing particle size and increasing gap between the particles, and its variation with the Clausius-Mossotti factor becomes increasingly nonlinear with decreasing particle size.

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“…(2) where r ij is the unit vector in the direction from the center of i-th particle to the center of j-th particle [22].…”

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Control of electrostatic particle-particle interactions in dielectrophoresis

Aubry¹,

Singh²

2006

Europhys. Lett.

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“…In addition to being exposed to the bulk electric field, two polarized particles i and j close to each other interact electrostatically, with the time-averaged interaction force between them, within the framework of the PD model, being [22]…”

Section: Electrostatic Forcesmentioning

confidence: 99%

Electrohydrodynamics of yeast cells in microchannels subjected to travelling electric fields

Nudurupati¹,

Aubry²,

Singh³

2006

J. Phys. D: Appl. Phys.

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While travelling wave dielectrophoresis (twDEP) offers a promising method for the control of micro-sized particles suspended in liquids, particularly when the motion of particles along the length of the channel is sought without having to pump the liquid itself, it leads to a variety of complex dynamical regimes which need to be clearly understood for the design of efficient microfluidic devices targeting particular functions. In this paper, we describe the various dynamical regimes in terms of the forces acting on the particles, i.e. the conventional dielectrophoretic and twDEP force and torque, the viscous drag exerted by the fluid on the particle and the electrostatic and hydrodynamic particle–particle interactions. We also explore the variation of the dynamical regimes in three different configurations typical of microfluidic channels whose electrodes are embedded in the bottom wall. The first two configurations have different, i.e. aligned and staggered, electrode geometries, and the third configuration consists of aligned electrodes but energized at different potentials. For these purposes, we use our direct numerical simulation code based on the distributed Lagrange multiplier method for solving the equations of motion for both the fluid and the individual particles, and the point dipole model to compute the electrostatic forces. The model particles are chosen so as to have mechanical and electrical properties of yeast cells suspended in an aqueous solution. It is found that the motion of the particles not only depends significantly on the Clausius–Mossotti factor, which is a function of the electric properties of the fluid and the particles, but also on the specific configuration considered. Particularly, the spinning of particles plays a crucial role in the particle translations and interactions, but the direction of such spinning motion depends on the particular device configuration used.

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The potential of a dielectrophoresis activated cell sorter (DACS) as a next generation cell sorter

Lee

Hwang

Kim

2016

Micro and Nano Syst Lett

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Originally introduced by H. A. Pohl in 1951, dielectrophoretic (DEP) force has been used as a striking tool for biological particle manipulation (or separation) for the last few decades. In particular, dielectrophoresis activated cell sorters (DACSes) have been developed for applications in various biomedical fields. These applications include cell replacement therapy, drug screening and medical diagnostics. Since a DACS does not require a specific bio-marker, it is able to function as a biological particle sorting tool with numerous configurations for various cells [e.g. red blood cells (RBCs), white blood cells (WBCs), circulating tumor cells, leukemia cells, breast cancer cells, bacterial cells, yeast cells and sperm cells]. This article explores current DACS capabilities worldwide, and it also looks at recent developments intended to overcome particular limitations. First, the basic theories are reviewed. Then, representative DACSes based on DEP trapping, traveling wave DEP systems, DEP field-flow fractionation and DEP barriers are introduced, and the strong and weak points of each DACS are discussed. Finally, for the purposes of commercialization, prerequisites regarding throughput, efficiency and recovery rates are discussed in detail through comparisons with commercial cell sorters (e.g. fluorescent activated and magnetic activated cell sorters).

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Particle Separation Using Dielectrophoresis

Cited by 3 publications

References 0 publications

Control of electrostatic particle-particle interactions in dielectrophoresis

Control of electrostatic particle-particle interactions in dielectrophoresis

Electrohydrodynamics of yeast cells in microchannels subjected to travelling electric fields

The potential of a dielectrophoresis activated cell sorter (DACS) as a next generation cell sorter

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