Particle size control of monodispersed spherical nanoparticles with MCM-48-type mesostructure via novel rapid synthesis procedure

Yismaw, Shewaye; Schneider, Denise; Poppitz, David; Ebbinghaus, Stefan G.; Gläser, Roger; Tallarek, Ulrich; Enke, Dirk

doi:10.1007/s11051-019-4699-7

Cited by 13 publications

(9 citation statements)

References 52 publications

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“…This size is because the measurement with PSA–DLS is a hydrodynamic measurement of the diameter of the nanoparticles. The results related to the size of the PSN align with Yismaw et al’s research on synthesizing monodispersed PSN nanoparticles 41 that the presence of TEA and F-g127 increases the dispersity of nanoparticles.…”

Section: Resultssupporting

confidence: 85%

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Radioiodination of Modified Porous Silica Nanoparticles as a Potential Candidate of Iodine-131 Drugs Vehicle

Prihatiningsih

Ariyanto

Putra³

et al. 2022

ACS Omega

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There are challenges related to cancer treatment, namely, targeting and biocompatibility associated with a drug vehicle. This research aims to prepare a theranostic cancer vehicle based on porous silica nanoparticles (PSN) with controllable nanoparticle size, supporting targeting properties, and biocompatible. The synthesis method combined the Stöber process and liquid crystal templating using a dispersant and pore expander. Triethanolamine (TEA) and Pluronic F-127 were combined as a steric stabilizer and dispersing agent, while n -hexane was used as a pore expander. The amine functionalization was carried out using the 3-aminopropyl-triethoxysilane solution. Furthermore, radiolabeling of PSN using Iodine-131 and iodogen as oxidizing agents was carried out. The results showed that the best achievable PSN size was 100–150 nm with a polydispersity index of 0.24 using TEA-Pluronic F-127. The functionalization results did not significantly affect the radioiodination result. Radiochemical purity (RCP) values up to 95% were obtained in the radioiodination, while the labeled compounds were relatively stable with 12 mCi radioactivity, indicating the absence of radiolysis. The synthesized PSN was not toxic to normal cell samples up to a concentration of 150 μg/mL for PSN and 170 μg/mL for PSN-NH 2 . The cellular uptake testing results of the PSN- 131 I in cancer cell samples showed promising uptake ability.

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Section: Resultssupporting

confidence: 85%

“…Then, a combination of dispersant compounds and a steric stabilizer such i.e., triethanolamine (TEA) and PEG was used to design the size of the nanoparticles. Therefore, Pluronic F-127 was used as a substitute for PEG-silane. , …”

Section: Resultsmentioning

confidence: 99%

Radioiodination of Modified Porous Silica Nanoparticles as a Potential Candidate of Iodine-131 Drugs Vehicle

Prihatiningsih

Ariyanto

Putra³

et al. 2022

ACS Omega

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“…MSNs produced using ammonia showed highly agglomerated spherical particles with a mean size of 420 nm. However, by changing the base to TEA, the particle size reduced to 186 nm, and they concluded that TEA served as both the catalyst and growth controlling additive [ 41 ]. Besides TEA and ammonia, sodium hydroxide is the most common reagent being used as catalysts in MSNs production.…”

Section: Fabrication Of Msnsmentioning

confidence: 99%

Progress in Mesoporous Silica Nanoparticles as Drug Delivery Agents for Cancer Treatment

et al. 2021

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Cancer treatment and therapy have made significant leaps and bounds in these past decades. However, there are still cases where surgical removal is impossible, metastases are challenging, and chemotherapy and radiotherapy pose severe side effects. Therefore, a need to find more effective and specific treatments still exists. One way is through the utilization of drug delivery agents (DDA) based on nanomaterials. In 2001, mesoporous silica nanoparticles (MSNs) were first used as DDA and have gained considerable attention in this field. The popularity of MSNs is due to their unique properties such as tunable particle and pore size, high surface area and pore volume, easy functionalization and surface modification, high stability and their capability to efficiently entrap cargo molecules. This review describes the latest advancement of MSNs as DDA for cancer treatment. We focus on the fabrication of MSNs, the challenges in DDA development and how MSNs address the problems through the development of smart DDA using MSNs. Besides that, MSNs have also been applied as a multifunctional DDA where they can serve in both the diagnostic and treatment of cancer. Overall, we argue MSNs provide a bright future for both the diagnosis and treatment of cancer.

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“…7 There are approaches that have been used to control the particle size of HMSN such as varying the concentration of synthesis components (silica precursors and catalysts), changing reaction conditions (temperature, pH), and addition of dispersing agents or capping agents. [8][9][10][11] Among these, capping agents seems to be a simple and effective method where molecules are added into the synthesis mixture to absorb selectively onto particles' surface, decrease the particle surface energy and consequently promote the growth of the particles. 12 Polyethylene glycol (PEG), a familiar water-soluble polyether with good biocompatibility, hydrophilicity and rapid degradability, has been commonly used as a capping agent in colloidal syntheses to control the size of nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

“…It has been reported that nanoparticle size had important effects on not only their ability to overcome the transport barriers in biological tissues but also their drug loading capacity 7 . There are approaches that have been used to control the particle size of HMSN such as varying the concentration of synthesis components (silica precursors and catalysts), changing reaction conditions (temperature, pH), and addition of dispersing agents or capping agents 8–11 . Among these, capping agents seems to be a simple and effective method where molecules are added into the synthesis mixture to absorb selectively onto particles' surface, decrease the particle surface energy and consequently promote the growth of the particles 12…”

Section: Introductionmentioning

confidence: 99%

Simply and effectively control the shell thickness of hollow mesoporous silica nanoparticles by polyethylene glycol for drug delivery applications

Nguyen

Tran

Truong‐Thi

et al. 2022

J of Applied Polymer Sci

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This study reports for the first time the usage of polyethylene glycol (PEG) as the capping agent to control mesoporous shell thickness of hollow mesoporous silica nanoparticles (HMSN)—a promising nanocarrier. HMSN was synthesized with hard template method and PEG with different molecular weights and concentrations would be added at the mesoporous coating. The samples dSiO2@MSN synthesized with and without PEG were analyzed DLS, field‐emission scanning electron microscopy, Brunauer–Emmett–Teller and Barrett–Joyner–Halenda to characterize their mesoporous shells. Meanwhile transmission electron microscope, Zeta potential, energy dispersive X‐ray spectroscopy, Fourier‐transform infrared, loading capacity, release profile and cytotoxicity analysis was conducted to characterize HSMNs. As PEG's molecular weight or concentration increased, the mesoporous shell thickness gradually raised. Particles synthesized in the presence of 2% PEG 6000 retained the monodispersed spherical morphology with a particle diameter of 95.40 nm and a mesoporous shell thickness of 14.40 nm, which was about 7.0 nm thicker. dSiO2@MSN‐P owned equal mesopore diameter and higher surface area compared to dSiO2@MSN‐0. HMSN‐P showed similar loading capacity but better sustained release profile than HMSN‐0. Moreover, both HMSN‐0 and HMSN‐P performed as biocompatible materials. This study would contribute a simple and effective method to control the shell thickness of HMSN with PEG for drug delivery applications.

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Particle size control of monodispersed spherical nanoparticles with MCM-48-type mesostructure via novel rapid synthesis procedure

Cited by 13 publications

References 52 publications

Radioiodination of Modified Porous Silica Nanoparticles as a Potential Candidate of Iodine-131 Drugs Vehicle

Radioiodination of Modified Porous Silica Nanoparticles as a Potential Candidate of Iodine-131 Drugs Vehicle

Progress in Mesoporous Silica Nanoparticles as Drug Delivery Agents for Cancer Treatment

Simply and effectively control the shell thickness of hollow mesoporous silica nanoparticles by polyethylene glycol for drug delivery applications

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