Particle size design of acetaminophen using supercritical carbon dioxide to improve drug delivery: Experimental and modeling

Bagheri, Hamidreza; Hashemipour, Hassan; Rahimpour, Elham; Rahimpour, Mohammad Reza

doi:10.1016/j.jece.2021.106384

Cited by 22 publications

(7 citation statements)

References 82 publications

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“…The topical delivery and bioactivity of niaouli essential oil has also been increased using a nanoemulsion technique [ 32 ]. Recently, some innovative techniques based on the application of supercritical carbon dioxide for the controlled and targeted drug delivery systems have been investigated [ 33 , 34 , 35 ]. However, the antiarthritic potential of nanostructured CO has not been studied via a topical drug delivery system.…”

Section: Introductionmentioning

confidence: 99%

Investigating Antiarthritic Potential of Nanostructured Clove Oil (Syzygium aromaticum) in FCA-Induced Arthritic Rats: Pharmaceutical Action and Delivery Strategies

et al. 2021

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The combined application of clove oil in a lipid nanocarrier opens a promising avenue for bone and joints therapy. In this study, we successfully developed a tunable controlled-release lipid platform for the efficient delivery of clove oil (CO) for the treatment of rheumatoid arthritis (RA). The ultra-small nanostructured lipid carriers co-loaded with CO (CONCs) were developed through an aqueous titration method followed by microfluidization. The CONCs appeared to be spherical (particle size of 120 nm), stable (zeta potential of −27 mV), and entrapped efficiently (84.5%). In toluene:acetone:glacial acetic acid (90:9:1 percent v/v/v) solvent systems, high-performance thin layer chromatography (HPTLC) analysis revealed the primary components in CO as eugenol (RF = 0.58). The CONCs greatly increased the therapeutic impact of CO in both in vitro and in vivo biological tests, which was further supported by excellent antiarthritic action. The CONC had an antiarthritic activity that was slightly higher than neat CO and slightly lower than standard, according to our data. The improved formulation inhibited serum lysosomal enzymes and proinflammatory cytokines while also improving hind leg function. This study provides a proof of concept to treat RA with a new strategy utilizing essential oils via nanodelivery.

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Section: Introductionmentioning

confidence: 99%

Investigating Antiarthritic Potential of Nanostructured Clove Oil (Syzygium aromaticum) in FCA-Induced Arthritic Rats: Pharmaceutical Action and Delivery Strategies

et al. 2021

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“…The moment transformation method offers a robust mathematical approach that simplifies the analysis and calculation process, enabling an efficient and accurate solution to the equation. − The moment transformation method regresses the model’s parameters using corresponding moments from system analysis to match the experimental data’s moments for the system output variables …”

Section: Experimental and Theoretical Methodsmentioning

confidence: 99%

Online In Situ Real-Time Experimental Investigation of the Crystallization Characteristics and Kinetic Models during the Nucleation and Growth Process of Para-Xylene Suspension Crystallization

Dong,

Wu,

Wang

et al. 2024

Ind. Eng. Chem. Res.

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The environmentally friendly and efficient preparation of high-purity P-xylene (PX) through suspension crystallization technology holds great significance for further advancement of the petrochemical industry. This review innovatively conducts experimental research on the entire process of PX intermittent suspension crystallization without the addition of crystal seeds in order to further clarify the details of the PX crystallization behavior. Online in situ imaging technology is used for the first time to monitor the real-time changes in the shape and particle size information on PX crystals during the crystallization process of low melting point xylene systems. Then, we derive the nucleation and growth kinetic equations of PX crystallization without adding seeds and further explore its crystallization kinetics and thermodynamic mechanism. The results can be concluded as follows. The PX crystal shape is primarily regular elongated rectangles. Without the addition of seeds, the crystal number and size rapidly increase at the moment of nucleation, the final average particle size is around 425 μm. The solution supersaturation decreased rapidly in the initial stage of crystallization and stabilized after 20 min. As the stirring speed increases, the crystal aggregation decreases, the fragmentation degree increases, and the average particle size decreases monotonically. The crystal purity is highest at 400 rpm. The mechanism by which stirring speed affects the particle size distribution of PX crystals will vary with changes in the crystallization time. The fitted crystallization kinetic equations can accurately reflect the actual nucleation and growth rates. This work is expected to theorize, model, and parametrize the PX suspension crystallization process.

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“…The Lunnan Oilfield belongs to the Lunnan Low Bulge Lunnan Fault Zone tectonics of the Tarim Basin Tabei Uplift. It is an almost east-west trending long-axis anticline, which appears as an irregular skirt extending into the central depression, forming a set of fan delta-braided river delta-lacustrine facies sediments [15]. Well grain size analysis by borehole coring indicates that the lithology of the Lunnan Oil formation is predominantly a medium sandstone composed of quartz, feldspar, lithic debris, and miscellaneous matrix.…”

Section: Geological Characteristicsmentioning

confidence: 99%

Experimental Study on Carbon Dioxide Flooding Technology in the Lunnan Oilfield, Tarim Basin

Wu,

Feng,

Tang

et al. 2024

Energies

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The Lunnan Oilfield in the Tarim Basin is known for its abundant oil and gas resources. However, the marine clastic reservoir in this oilfield poses challenges due to its tightness and difficulty in development using conventional water drive methods. To improve the recovery rate, this study focuses on the application of carbon dioxide flooding after a water drive. Indoor experiments were conducted on the formation fluids of the Lunnan Oil Formation, specifically investigating gas injection expansion, thin tube, long core displacement, oil and gas phase permeability, and solubility. By injecting carbon dioxide under the current formation pressure, the study explores the impact of varying amounts of carbon dioxide on crude oil extraction capacity, high-pressure physical parameters of crude oil, and phase characteristics of formation fluids. Additionally, the maximum dissolution capacity of carbon dioxide in formation water is analyzed under different formation temperatures and pressures. The research findings indicate that the crude oil extracted from the Lunnan Oilfield exhibits specific characteristics such as low viscosity, low freezing point, low-medium sulfur content, high wax content, and medium colloid asphaltene. The measured density of carbon dioxide under the conditions of the oil group is 0.74 g/cm3, which closely matches the density of crude oil. Additionally, the viscosity of carbon dioxide is 0.0681 mPa·s, making it well-suited for carbon dioxide flooding. With an increase in the amount of injected carbon dioxide, the saturation pressure and gas-oil ratio of the crude oil also increase. As the pressure rises, carbon dioxide dissolves rapidly into the crude oil, resulting in a gradual increase in the gas-oil ratio, expansion coefficient, and saturation pressure. As the displacement pressure decreases, the degree of carbon dioxide displacement initially decreases slowly, followed by a rapid decrease. Moreover, an increase in the injection rate of carbon dioxide pore volume leads to a rapid initial improvement in oil-displacement efficiency, followed by a slower increase. Simultaneously, the gas-oil ratio exhibits a slow increase initially, followed by a rapid rise. Furthermore, as the displacement pressure increases, the solubility of carbon dioxide in water demonstrates a linear increase. These research findings provide valuable theoretical data to support the use of carbon dioxide flooding techniques for enhancing oil recovery.

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Particle size design of acetaminophen using supercritical carbon dioxide to improve drug delivery: Experimental and modeling

Cited by 22 publications

References 82 publications

Investigating Antiarthritic Potential of Nanostructured Clove Oil (Syzygium aromaticum) in FCA-Induced Arthritic Rats: Pharmaceutical Action and Delivery Strategies

Investigating Antiarthritic Potential of Nanostructured Clove Oil (Syzygium aromaticum) in FCA-Induced Arthritic Rats: Pharmaceutical Action and Delivery Strategies

Online In Situ Real-Time Experimental Investigation of the Crystallization Characteristics and Kinetic Models during the Nucleation and Growth Process of Para-Xylene Suspension Crystallization

Experimental Study on Carbon Dioxide Flooding Technology in the Lunnan Oilfield, Tarim Basin

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