Particle Size of Inhalation Aerosol Systems I: Production of Homogenous Dispersions

Abstract

School of Pharucy. Brighton Polytechnic. kdrecooclb, Brighton BNZ 4(tl Production of Mowgenow Diaperdona Ihr w t h o d s uaed t o s i t e i n h a l a t i o n oeroaols and the p r o b l e m involved i n prodiicing an hoaogenow c l o d of aeroaol p a r t i c l e a are reviewed. rnre carried out uaing a Eoyco 2251508 p n r t i c l e size analyscr.

Standards for Bioequivalence of Inhaled Products

“…In vitro methods of analysis of inhaled products have largely involved the twin impinger (Hall worth & Westmoreland 1987), cascade impactor (Sciarra & Cutie 1978) and light scattering methods (Davies et al 1980). In vivo methods of assessing delivery of inhaled therapy to the lungs include pharmacodynamic performance, y-scintigraphy and pharmacokinetic assessment of blood and/or urine concentrations of the drug.…”