Particle size segregation promoted by powder flow in confined space: The die filling process case

Mateo-Ortiz, Daniel; Muzzio, Fernando J.; Méndez, Rafael

doi:10.1016/j.powtec.2014.04.023

Cited by 70 publications

(19 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…With an increase in the turret speed, the mean tablet weight decreases, which reflects the influence of the turret speed on the mean weight . Die filling is a complex process, which involves gravity feeding, suction filling, and air replacement and is influenced by operating parameters, such as the turret speed that also determines centrifugal forces and vibrations of the press.…”

Section: Resultsmentioning

confidence: 99%

A Continuous Operation Concept for a Rotary Tablet Press Using Mass Flow Operating Points

Martinetz

Rehrl

Aigner

et al. 2017

Chemie Ingenieur Technik

View full text Add to dashboard Cite

In a continuous pharmaceutical manufacturing line the rotary tablet press was viewed as the master of control concept and defined the mass flow through the entire process. According to a conventional control concept, missing mass flow from an upstream unit operation leads to a shutdown of the tablet press. Various operating scenarios were simulated and the influence of turret speed on the tablet properties was experimentally investigated. Changes in the turret speed alter the critical process parameters dwell time and die filling time. Their influence was evaluated using two model formulations with different compaction behavior.

show abstract

Section: Resultsmentioning

confidence: 99%

A Continuous Operation Concept for a Rotary Tablet Press Using Mass Flow Operating Points

Martinetz

Rehrl

Aigner

et al. 2017

Chemie Ingenieur Technik

View full text Add to dashboard Cite

show abstract

“…Figure 9 demonstrates this phenomenon [106]. Mateo-Ortiz et al [107] studied particle size segregation in a feed frame and during die filling, finding that the paddle wheel speed in the feed frame was important in controlling the degree of segregation. More segregation was observed at lower paddle wheel speeds, and percolation, or the movement of small particles through the void space, was identified as the primary segregation mechanism.…”

Section: Die Filling and Tablet Compactionmentioning

confidence: 91%

Discrete Element Modeling of Solid Dosage Manufacturing Processes

Barrasso

Ramachandran

2016

Methods in Pharmacology and Toxicology

View full text Add to dashboard Cite

Solid dosage manufacturing primarily involves powder process operations, such as mixing, granulation, and compaction. A model-based approach can be used to develop a better scientific understanding of these processes and implement Quality by Design. These models must predict the critical quality attributes of the product based on process parameters, equipment geometry, and material properties. Discrete element modeling (DEM) is often used to capture mechanistic, particle-scale information, such as velocity and force profiles. In this chapter, recent literature studies that use the DEM to model solid dosage manufacturing processes will be presented and discussed.

show abstract

“…However, the powder flow through the tablet press in general and the feed frame especially is known to possibly cause several unwanted changes of the powder blend properties, which result in an alteration of tablet-quality defining attributes, e.g., mechanical strength. There have been several recent studies regarding the effect of the feed frame on bulk properties, both experimental [11][12][13][14] as well as computational studies [15][16][17]. They identified various mechanisms negatively affecting the bulk properties, including overlubrication and abrasion caused by stresses in the feed frame, as well as segregation of blends.…”

Section: Powder Flow In Rotary Tablet Pressesmentioning

confidence: 99%

Impact of Particle and Equipment Properties on Residence Time Distribution of Pharmaceutical Excipients in Rotary Tablet Presses

Puckhaber

Eichler²,

Kwade

et al. 2020

Pharmaceutics

View full text Add to dashboard Cite

Paddle feeders are devices commonly used in rotary tablet presses to facilitate constant and efficient die filling. Adversely, the shear stress applied by the rotating paddles is known to affect the bulk properties of the processed powder dependent on the residence time. This study focuses on the residence time distribution (RTD) of two commonly applied excipients (microcrystalline cellulose, MCC; dicalcium phosphate, DCP), which exhibit different flow properties inside rotary tablet presses. To realistically depict the powder flow inside rotary tablet presses, custom-made tracer powder was developed. The applied method was proven to be appropriate as the tracer and bulk powder showed comparable properties. The RTDs of both materials were examined in two differently scaled rotary tablet presses and the influence of process parameters was determined. To analyze RTDs independent of the mass flow, the normalized variance was used to quantify intermixing. Substantial differences between both materials and tablet presses were found. Broader RTDs were measured for the poorer flowing MCC as well as for the production scale press. The obtained results can be used to improve the general understanding of powder flow inside rotary tablet presses and amplify scale-up and continuous production process development.

show abstract

Particle size segregation promoted by powder flow in confined space: The die filling process case

Cited by 70 publications

References 32 publications

A Continuous Operation Concept for a Rotary Tablet Press Using Mass Flow Operating Points

A Continuous Operation Concept for a Rotary Tablet Press Using Mass Flow Operating Points

Discrete Element Modeling of Solid Dosage Manufacturing Processes

Impact of Particle and Equipment Properties on Residence Time Distribution of Pharmaceutical Excipients in Rotary Tablet Presses

Contact Info

Product

Resources

About