2023
DOI: 10.5812/ijpr-130626
|View full text |Cite
|
Sign up to set email alerts
|

Particle Size Tailoring of Quercetin Nanosuspensions by Wet Media Milling Technique: A Study on Processing and Formulation Parameters

Abstract: Background: A large number of new substances have insufficient biopharmaceutical properties for oral administration caused by their slow dissolution rate and poor solubility. Objective: The purpose of our experiment was to improve the physicochemical properties of a hydrophobic drug, quercetin, by the nanomilling approach. Methods: Quercetin nanosuspensions were prepared using a wet-milling method followed by lyophilization. Stabilizer type and ratio, drug content, milling time, and bead size were identified a… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2024
2024
2024
2024

Publication Types

Select...
2

Relationship

0
2

Authors

Journals

citations
Cited by 2 publications
(1 citation statement)
references
References 45 publications
0
1
0
Order By: Relevance
“…The synergistic effects of friction and impact result in a significant decrease in particle size. The milling media, also known as balls, utilised in this study are composed of ceramic-sintered aluminium oxide, zirconium oxide, or strongly cross-linked polystyrene resin, as mentioned in the planetary ball mill research conducted by reference 19 . In order to obtain effective formulation and to reduce the time of media milling drug can be subjected to prior homogenization followed by media milling 20 .…”
Section: Media Millingmentioning
confidence: 99%
“…The synergistic effects of friction and impact result in a significant decrease in particle size. The milling media, also known as balls, utilised in this study are composed of ceramic-sintered aluminium oxide, zirconium oxide, or strongly cross-linked polystyrene resin, as mentioned in the planetary ball mill research conducted by reference 19 . In order to obtain effective formulation and to reduce the time of media milling drug can be subjected to prior homogenization followed by media milling 20 .…”
Section: Media Millingmentioning
confidence: 99%