Particle Trapping in High-Conductivity Media with Electrothermally Enhanced Negative Dielectrophoresis

Park, Seungkyung; Köklü, Mehti; Beşkök, Ali

doi:10.1021/ac802471g

Cited by 85 publications

(84 citation statements)

References 26 publications

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“…11,15 Dielectrophoresis refers to a nonlinear electrokinetic phenomenon 30 in which a force is exerted on a dielectric particle when it is subjected to a spatially nonuniform electric field. This kind of electrokinetic phenomenon has been widely used to manipulate spherical particles in microfluidics such as particle trapping, [31][32][33][34][35] separation, 16,[35][36][37][38][39][40][41] focusing, 14,18,35 and cell discrimination. 42,43 Previous numerical and experimental studies demonstrate that the DEP effect should be taken into account to study the electrokinetic transport of spherical particles where nonuniform electric fields are present.…”

Section: Introductionmentioning

confidence: 99%

dc electrokinetic transport of cylindrical cells in straight microchannels

Beşkök

Gauthier

et al. 2009

Biomicrofluidics

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Electrokinetic transport of cylindrical cells under dc electric fields in a straight microfluidic channel is experimentally and numerically investigated with emphasis on the dielectrophoretic ͑DEP͒ effect on their orientation variations. A twodimensional multiphysics model, composed of the Navier-Stokes equations for the fluid flow and the Laplace equation for the electric potential defined in an arbitrary Lagrangian-Eulerian framework, is employed to capture the transient electrokinetic motion of cylindrical cells. The numerical predictions of the particle transport are in quantitative agreement with the obtained experimental results, suggesting that the DEP effect should be taken into account to study the electrokinetic transport of cylindrical particles even in a straight microchannel with uniform cross-sectional area. A comprehensive parametric study indicates that cylindrical particles would experience an oscillatory motion under low electric fields. However, they are aligned with their longest axis parallel to the imposed electric field under high electric fields due to the induced DEP effect.

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Section: Introductionmentioning

confidence: 99%

dc electrokinetic transport of cylindrical cells in straight microchannels

Beşkök

Gauthier

et al. 2009

Biomicrofluidics

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“…Among the various mechanisms to manipulate particles using electrically induced forces, dielectrophoresis (DEP) is the most frequently utilized in microfluidic systems [29,40,48,51,[65][66][67][68][69][70]. DEP is defined as the motion of neutral or semi-conducting particles produced by the application of a non-uniform electric field [40,51,71,72].…”

Section: Dielectrophoresismentioning

confidence: 99%

“…The DEP force is generally produced by an inhomogeneous electrode system such as castellated or interdigitated planar microelectrodes providing a non-uniform electric field [29,69,70,[73][74][75]. The intensity of the applied electric field is highest in the region between two closely spaced electrodes.…”

Section: Dielectrophoresismentioning

confidence: 99%

Microfluidic Technology for Cell Manipulation

Kwon

2018

Applied Sciences

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Featured Application: Microfluidic manipulation techniques not only improve the efficiency and reliability of biological/clinical analysis, but also further enable the development of a high-performance bioassay system. Abstract: Microfluidic techniques for cell manipulation have been constantly developed and integrated into small chips for high-performance bioassays. However, the drawbacks of each of the techniques often hindered their further advancement and their wide use in biotechnology. To overcome this difficulty, an examination and understanding of various aspects of the developed manipulation techniques are required. In this review, we provide the details of primary microfluidic techniques that have received much attention for bioassays. First, we introduce the manipulation techniques using a sole driving source, i.e., dielectrophoresis, electrophoresis, optical tweezers, magnetophoresis, and acoustophoresis. Next, we present rapid electrokinetic patterning, a hybrid opto-electric manipulation technique developed recently. It is introduced in detail along with the underlying physical principle, operating environment, and current challenges. This paper will offer readers the opportunity to improve existing manipulation techniques, suggest new manipulation techniques, and find new applications in biotechnology.

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“…10,20 Because the DEP force depends on various factors, many of which are intrinsic to the particle, including the particle size, polarizability, and speed of polarization alignment, DEP is a useful tool for probing differences among particles with different dielectric properties, primarily through physical sorting based on the forces associated with DEP. [57][58][59][60][61] For homogeneous spherical particles, the dielectric force is governed bỹ…”

Section: B Dielectrophoretic Particle Separationmentioning

confidence: 99%

Microfluidic dielectrophoretic sorter using gel vertical electrodes

Luo

Nelson

Li³

et al. 2014

Biomicrofluidics

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We report the development and results of a two-step method for sorting cells and small particles in a microfluidic device. This approach uses a single microfluidic channel that has (1) a microfabricated sieve which efficiently focuses particles into a thin stream, followed by (2) a dielectrophoresis (DEP) section consisting of electrodes along the channel walls for efficient continuous sorting based on dielectric properties of the particles. For our demonstration, the device was constructed of polydimethylsiloxane, bonded to a glass surface, and conductive agarose gel electrodes. Gold traces were used to make electrical connections to the conductive gel. The device had several novel features that aided performance of the sorting. These included a sieving structure that performed continuous displacement of particles into a single stream within the microfluidic channel (improving the performance of downstream DEP, and avoiding the need for additional focusing flow inlets), and DEP electrodes that were the full height of the microfluidic walls ("vertical electrodes"), allowing for improved formation and control of electric field gradients in the microfluidic device. The device was used to sort polymer particles and HeLa cells, demonstrating that this unique combination provides improved capability for continuous DEP sorting of particles in a microfluidic device. V C 2014 AIP Publishing LLC.

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Particle Trapping in High-Conductivity Media with Electrothermally Enhanced Negative Dielectrophoresis

Cited by 85 publications

References 26 publications

dc electrokinetic transport of cylindrical cells in straight microchannels

dc electrokinetic transport of cylindrical cells in straight microchannels

Microfluidic Technology for Cell Manipulation

Microfluidic dielectrophoretic sorter using gel vertical electrodes

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