Particularités cliniques et radiologiques de la tuberculose pulmonaire chez le tabagique

Kombila, U.D.; Mbaye, F.B.R.; Kane, Y. Dia; Ka, W.; Badiane, N.O. Toure

doi:10.1016/j.rmr.2017.04.006

Cited by 5 publications

(5 citation statements)

References 20 publications

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“…Earlier studies reported that the incidence of severe lung lesions in smokers was higher [8][9][10] , and the present investigation further supported this theory of "Negative effects of smoking on CT findings" by the change in the cumulative amount of smoking (the smoking index) (Fig. 1a) .…”

Section: Discussionsupporting

confidence: 89%

“…Previous investigations reported that imaging progressive lesions were correlated with the increase of platelet count and thrombocytocrit 3,4 , cellular immune function 5,6 , low albumin 7 and smoking [8][9][10] , but inconsistent with correlation reports of diabetes mellitus 7,[11][12][13] and sputum bacterial load 7,14,15 . These investigations mainly employed univariate analysis, in which not only the diagnostic efficiency was low, but also the results were inconsistent.…”

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confidence: 88%

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A valuable computed tomography-based new diagnostic tool for severe chest lesions in active pulmonary tuberculosis: combined application of influencing factors

Jiang

Zhu

et al. 2020

Sci Rep

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The objective of the present investigation was to explore the influencing factors and value of computed tomography (ct) for diagnosing severe chest lesions in active pulmonary tuberculosis (AptB). this retrospective investigation included 463 patients diagnosed with APTB. Relevant clinical features were collected. patients were assigned to mild/moderate group or advanced group depending on the lesion severity on chest CT, severe chest CT lesion refers to the moderately dense or less diffuse lesion that exceeds the total volume of one lung, or the dense fusion lesion greater than one third of the volume of one lung, or the lesion with cavity diameter ≥4 cm. Independent risk factors for severe lesions were determined by univariate and multivariate logistic regression analyses, and the diagnostic efficiency of the risk factors was assessed by receiver operating characteristic curve (ROC). Chest CT demonstrated that there were 285 (61.56%) cases with severe lesions; multivariate Logistic regression analysis showed dust exposure [odds ratio (oR) = 4.108, 95% confidence interval (CI) 2.416-6.986], patient classification (OR = 1.792, 95% CI 1.067-3.012), age (OR = 1.018, 95% CI 1.005-1.030), and albuminglobulin ratio (oR = 0.179, 95% CI 0.084-0.383) to be independently correlated with severe lesions on chest CT. ROC curve analysis showed the cutoff values of age, albumin-globulin ratio and combined score to be 39 years, 0.918 and −0.085, respectively. The predictive value of combined score area under the curve 0.753 (95% CI 0.708-0.798) was higher than that of any single factor. The combined score of these four factors further improved the predictive efficacy.

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Section: Discussionsupporting

confidence: 89%

mentioning

confidence: 88%

A valuable computed tomography-based new diagnostic tool for severe chest lesions in active pulmonary tuberculosis: combined application of influencing factors

Jiang

Zhu

et al. 2020

Sci Rep

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“…Similar to studies conducted in Senegal and Iran, 14,15 we found a 30% prevalence of smokers among the included patients. This prevalence is higher than that reported in the general Gabonese population, especially in men.…”

Section: Discussionsupporting

confidence: 88%

“…19,20 Although the most common symptom of TB is cough, it may be difficult to perceive coughing as a hint to an underlying condition such as TB in smoking patients who are prone to coughing anyway. As in studies from Tunisia and Senegal, 14,21 smokers in our study experienced more signs and symptoms. Smoking severely impedes the pulmonary immune system's function mainly via the inhibition of innate immune responses and pulmonary T-cell recruitment.…”

Section: Discussionsupporting

confidence: 86%

Epidemiological, Mycobacteriological, and Clinical Characteristics of Smoking Pulmonary Tuberculosis Patients, in Lambaréné, Gabon: A Cross-Sectional Study

Adégbitè

Edoa

Agbo

et al. 2020

The American Journal of Tropical Medicine and Hygiene

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Gabon carries a high burden of both tuberculosis (TB) and smoking. This study examines the disease characteristics of smoking pulmonary TB patients in Lambar én é. We interviewed adult pulmonary TB patients in Lambar én é, between March 2016 and April 2019. Clinical and biological patient characteristics were collected. Bivariate and logistic regression analyses were performed to assess factors associated with smoking. The mean age of patients included was 31 years (±13). The proportion of smokers in our study was 30% (89/295). Smoking was significantly associated with patient-related diagnostic delay (adjusted odds ratio [AOR] = 8.18; 95% CI = 3.67-19.56), a higher number of pulmonary TB signs and symptoms (AOR = 2.74; 95% CI = 1.18-6.73), and a higher sputum mycobacterial load (AOR = 3.18; 95% CI = 1.33-8.11). The prevalence of smoking among TB patients is high, and leading to aggravated disease as compared with controls. Our study findings suggest that smoking patients should be regularly screened for TB, to reduce diagnostic delay and TB transmission within community. Smoking cessation activities should be included in the national TB control program in Gabon.

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“…Miliary TB is rare in post-primary TB, although it can present as late TB and is mostly diagnosed after the patient's death, where signs of chronic tuberculosis are seen, such as calcifications and disseminated fibrosis. 30 Lymphadenopathy is rare in post-primary TB, occurring in around 5-6% of all cases, and is usually accompanied by cavitations and extensive involvement of the parenchyma. 31 Another radiological finding is fibrosis and bronchostenosis, which is caused by scarring of the lung tissue in patients with TB, where collapse of the lung segments or lobes, hyperinflation, obstructive pneumonitis and even mucoid impaction can be seen.…”

Section: Radiological Findings In Post-primary Tbmentioning

confidence: 99%

Radiological Findings in the Diagnosis of Pulmonary Tuberculosis

Núñez,

Ochoa,

Jácome

et al. 2023

JHS

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Introduction:Pulmonary tuberculosis is a contagious bacterial disease that causes high morbidity and mortality in the world, which produces non-specific symptoms, making its diagnosis difficult. For this, it is necessary to correlate clinical data with laboratory tests and imaging tests, which range from to serve to confirm or rule out the pathology and to classify it according to its pathophysiology. For better study, it is classified pathophysiologically into primary and post-primary tuberculosis depending on the time of exposure to the causal agent. The imaging tests most frequently used are chest x-rays and tomography, providing images suggestive of the presence of the disease, expressed in different ways in relation to its stage. Goal: Identify the prevalent radiological findings in pulmonary tuberculosis through a bibliographic review in the last 5 years in the Pubmed database, which allows the doctor to distinguish this condition in an effective way through this update. Conclusion: The imaging tools most used for the diagnosis of this pathology are chest x-ray and chest tomography, with tomography being the study with the greatest sensitivity and specificity, but in our environment due to the high cost and low economic level of the population, it is used less frequently. The chest x-ray, although it has less specificity, is essential in the diagnosis of TB, where depending on the radiological findings observed, it can be established at what stage of the disease the patient is experiencing.

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Particularités cliniques et radiologiques de la tuberculose pulmonaire chez le tabagique

Cited by 5 publications

References 20 publications

A valuable computed tomography-based new diagnostic tool for severe chest lesions in active pulmonary tuberculosis: combined application of influencing factors

A valuable computed tomography-based new diagnostic tool for severe chest lesions in active pulmonary tuberculosis: combined application of influencing factors

Epidemiological, Mycobacteriological, and Clinical Characteristics of Smoking Pulmonary Tuberculosis Patients, in Lambaréné, Gabon: A Cross-Sectional Study

Radiological Findings in the Diagnosis of Pulmonary Tuberculosis

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