Particulate air pollution impacts directly on bacterial pathogen behaviour and infection

Williams, Paul

doi:10.1111/1462-2920.13790

Cited by 2 publications

(3 citation statements)

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“…Particular matter (PM) may also be associated with the occurrence of peritonsillar abscess formation. It has been shown that PM is a mutagenic material that can induce oxidative stress, inflammation, and tissue damage and increase susceptibility to infection, and PM may directly effect bacterial pathogens . In a previous study, black carbon (the major component of PM) was shown to alter the biofilm structure of Staphylococcus pneumoniae and Staphylococcus aureus , induce changes in proteolytic degradation of biofilms, and alter the tolerance of biofilms to multiple antibiotics .…”

Section: Discussionmentioning

confidence: 99%

“…The tonsils are located in the upper respiratory tract and are in direct contact with the external environment. Moreover, air pollutants may influence the behavior of bacterial pathogens in the tonsils . However, to our knowledge, the association between air pollution and peritonsillar abscess formation has not been reported.…”

Section: Introductionmentioning

confidence: 85%

“…Moreover, air pollutants may influence the behavior of bacterial pathogens in the tonsils. 11,12 However, to our knowledge, the association between air pollution and peritonsillar abscess formation has not been reported. When the PubMed and EMBASE databases were searched for studies using the keyword phrases "peritonsillar abscess" and "air pollution," no articles were retrieved through September 2018.…”

mentioning

confidence: 88%

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Association of Air Pollution With Increased Risk of Peritonsillar Abscess Formation

Kim

Kong

Min

et al. 2019

JAMA Otolaryngol Head Neck Surg

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IMPORTANCE Several studies reported an association between peritonsillar abscess formation and climate conditions, including seasonal changes; however, the results were inconsistent.OBJECTIVE To evaluate the association between meteorological conditions and/or air pollution and peritonsillar abscess formation. DESIGN, SETTING, AND PARTICIPANTSIn this nested case-control study, 3819 participants with peritonsillar abscesses were matched (1:4) for age, sex, income, region of residence, hypertension, diabetes, and dyslipidemia with 15 276 control participants. The Korean Health Insurance Review and Assessment Service-National Sample Cohort (HIRA-NSC) data from 2002 through 2013 were used. EXPOSURES AND MAIN OUTCOMES AND MEASURESThe meteorological data included the mean daily temperature (°C), highest daily temperature (°C), lowest daily temperature (°C), daily temperature difference (°C), relative humidity (%), spot atmospheric pressure (hPa), sulfur dioxide ([SO 2 ], parts per million [ppm]), nitrogen dioxide (NO 2 , ppm), ozone (O 3 , ppm), carbon monoxide (CO, ppm), and particulate matter less than 10 μg (PM 10 , μg/m 3 ) for the previous 14 days, 10 days, 7 days, 5 days, or 3 days before the matched index date. These factors were measured in 94 or 273 locations hourly. The crude and adjusted odds ratios (aORs) and 95% confidence intervals (CIs) of meteorological data for peritonsillar abscess formation were analyzed using unconditional logistic regression analysis. Subgroup analyses were conducted according to age and sex. RESULTSThe male to female ratio of study participants was 1.43 (11 260 to 7835). Because the age groups were classified using 5-year intervals, the mean age could not be defined. The mean differences of NO 2 and PM 10 concentrations for the 14 days between peritonsillar abscess group and control group were 1.78 ppb (95% CI, 1.47-2.09) and 1.33 μg/m 3 (95% CI, 0.67-1.99), respectively. The aORs of NO 2 (0.1 ppm) and PM 10 (10 μg/m 3 ) during the 14 days prior to the index date for peritonsillar abscess formation were 12.8 (95% CI, 8.4-19.5) and 1.04 (95% CI, 1.02-1.06), respectively. The other meteorological conditions did not reach statistical significance.CONCLUSIONS AND RELEVANCE Peritonsillar abscess formation was associated with high concentrations of NO 2 and PM 10 .