Particulate-Induced, Prostaglandin- And Cytokine-Mediated Bone Resorption in an Experimental System and in Failed Joint Replacements

Glant, Tibor T.; Jacobs, Joshua J.; Mikecz, Katalin; Yao, J. C.; Chubinskaja, Susan; Williams, James M.; Urban, Robert L.; Shanbhag, Arun S.; Lee, Soo-Ho; Sumner, Dale R.

doi:10.1097/00045391-199601000-00006

Cited by 50 publications

(35 citation statements)

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“…These fibroblasts may be adjacent to osteoclasts in the IFM. 4 Because activated fibroblasts secrete RANKL, M-CSF, and VEGF, it may well be that the fibroblast is a key cell-type simultaneously mediating both angiogenesis and osteoclastogenesis in the periprosthetic space.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, the most granulomatous areas of the IFM, especially those resembling rheumatoid synovial tissue, are hypervascularized. 1,4,9,10,22 Overall, the pathological processes of osteoclastogenesis, dysregulated bone formation, and granulomatous tissue formation are simultaneous and overlapping events that cannot be separated. In this study, we hypothesized that the fibroblast plays a key role in angiogenesis within the periprosthetic tissues.…”

Section: Introductionmentioning

confidence: 99%

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Role of fibroblasts and fibroblast‐derived growth factors in periprosthetic angiogenesis

Tunyogi-Csapó

Koreny

Vermes

et al. 2007

Journal Orthopaedic Research

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ABSTRACT:The periprosthetic granulomatous soft tissue [designated iterfacial membrane (IFM) in this study] exhibits heterogeneous histopathological features, in which highly vascularized areas with dense cellularity alternate with fibrotic and pseudocapsule-like tissue structures. Although macrophage/monocyte activation is a prominent event in the periprosthetic environment, fibroblasts also phagocytose particulate wear debris both in vivo and in vitro. Particulate wear debris and/or cytokines/growth factors alone or in combination (e.g., in conditioned media of explant cultures of IFMs) stimulated normal synovial and IFM fibroblasts to express inflammatory mediators and growth factors such as interleukin (IL)-1b, IL-6, IL-8, three isoforms of vascular endothelial growth factor (VEGF), monocyte/macrophage chemoattractant protein-1 (MCP-1), macrophagecolony-stimulating factor (M-CSF), cycloxygenases (Cox-1 and Cox-2), acid-and basic-fibroblast growth factors (FGF-1 and FGF-2), leukemia inhibitory factor-1 (LIF-1), transforming growth factor b-1 (TGF-b1), receptor activator of nuclear factor-kappa B ligand (RANKL), and osteoprotegerin (OPG). Thus, the fibroblast is capable of expressing a wide array of angiogenic and osteoclastogenic factors which are involved in the detrimental processes of the periprosthetic osteolysis. ß

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Role of fibroblasts and fibroblast‐derived growth factors in periprosthetic angiogenesis

Tunyogi-Csapó

Koreny

Vermes

et al. 2007

Journal Orthopaedic Research

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“…This may be of great clinical relevance, as non-steroidal anti-inflammatory drugs (NSAIDs) are inhibitors of cyclooxygenase activity and are therefore potential therapeutic agents in the prevention of aseptic loosening. Indeed, cell culture studies have demonstrated the effectiveness of such drugs in reducing prostanoid production and bone resorption [7].…”

Section: Introductionmentioning

confidence: 99%

Early aseptic loosening of cemented total hip arthroplasty: the influence of non-steroidal anti-inflammatory drugs and smoking

Malik

Gray

Kay

2004

International Orthopaedics (SICOT)

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“…Particulate debris generated by wear stimulates the formation of an inflammatory reaction, which promotes a host-tissue response that has the ability to invade the bone-implant interface. [27][28][29][30][31]48,[50][51][52][53][54][55][56][57][58][59][60][61][62][63][64]66 This commonly results in progressive local bone loss that threatens the fixation of implanted devices. Despite their high resistance to corrosion, all metal alloy implants corrode in vivo.…”

Section: Biomaterials Used In Joint Replacementmentioning

confidence: 99%

The future of spinal arthroplasty: a biomaterial perspective

Oskouian

Whitehill²,

Samii³

et al. 2004

FOC

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Both total hip and knee arthroplasty have demonstrated outstanding clinical results. The functional spinal unit composed of the intervertebral disc and facet joints is at least as complex. The intricacies of the coupled motions of the functional spinal unit have made development of an artificial disc a challenge. There have been several failed attempts to create a disc replacement that recapitulates normal motion while providing significant longevity and a low incidence of complications. Better understanding of the biomechanics of the intervertebral disc complex and improvements in implant material have made successful intervertebral disc replacement a likely reality, now that several artificial discs have completed Food and Drug Administration clinical trials. In this manuscript the authors detail the biomaterials used in disc arthroplasty and discuss joint wear and the host response to wear debris.

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Particulate-Induced, Prostaglandin- And Cytokine-Mediated Bone Resorption in an Experimental System and in Failed Joint Replacements

Cited by 50 publications

References 0 publications

Role of fibroblasts and fibroblast‐derived growth factors in periprosthetic angiogenesis

Role of fibroblasts and fibroblast‐derived growth factors in periprosthetic angiogenesis

Early aseptic loosening of cemented total hip arthroplasty: the influence of non-steroidal anti-inflammatory drugs and smoking

The future of spinal arthroplasty: a biomaterial perspective

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