To assess the exposure of residents in rural communities in the Yukon Flats to particulate matter of 2.5 µm or less in diameter (PM 2.5), both indoor and outdoor concentration observations were carried out from March to September 2019 in Ft. Yukon, Alaska. Indoor concentrations were measured at 0.61 m (breathing level during sleeping) in homes and at 1.52 m heights (breathing level of standing adult) in homes and office/commercial buildings. Air quality was better at both heights in cabins than frame homes both during times with and without surface-based inversions. In frame houses, concentrations were higher at 0.61 m than 1.52 m, while the opposite is true typically for cabins. Differences between shoulder season and summer indoor concentrations in residences were related to changes in heating, subsistence lifestyle and mosquito repellents. In summer, office and commercial buildings, air quality decreased due to increased indoor emissions related to increased use of equipment and mosquito pics as well as more merchandise. During summer indoor concentrations reached unhealthy for sensitive groups to hazardous conditions for extended times that even exceeded the high outdoor concentrations. Due to nearby wildfires, July mean outdoor concentrations were 55.3 µg•m −3 which exceeds the 24-h US National Ambient Air Quality Standard of 35 µg•m −3. Indoor and outdoor concentrations correlated the strongest with each other for office/commercial buildings, followed by frame houses and cabins. Office/commercial buildings with temperature monitors had one to two orders of magnitude lower concentrations than those without.