Particulate matter-induced metabolic recoding of epigenetics in macrophages drives pathogenesis of chronic obstructive pulmonary disease

Noh, Myungkyung; Sim, Jeong Yeon; Kim, Jisung; Ahn, Jee Hwan; Min, Hye-Young; Lee, Jong-Uk; Park, Jong-Sook; Jeong, Ji Yun; Lee, Jae Young; Lee, Shin Yup; Lee, Hyo-Jong; Park, Choon-Sik; Lee, Ho-Young

doi:10.1016/j.jhazmat.2023.132932

Journal of Hazardous Materials

2024

DOI: 10.1016/j.jhazmat.2023.132932

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Particulate matter-induced metabolic recoding of epigenetics in macrophages drives pathogenesis of chronic obstructive pulmonary disease

Myungkyung Noh,

Jeong Yeon Sim,

Jisung Kim

et al.

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2024

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Cited by 4 publications

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Huang,

Chang

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Laboratory Investigation

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SIRT1: An Intermediator of Key Pathways Regulating Pulmonary Diseases

Jiang,

Huang,

Chang

et al. 2024

Laboratory Investigation

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Prenatal diagnosis and genetic counselling of a rare paternally inherited chromosome 2p21 microdeletion in a Chinese family

Wang,

Liu,

Tian

et al. 2024

Taiwanese Journal of Obstetrics and Gynecology

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Particulate matter-induced epigenetic modifications and lung complications

Afthab,

Hambo,

Kim

et al. 2024

Eur Respir Rev

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Air pollution is one of the leading causes of early deaths worldwide, with particulate matter (PM) as an emerging factor contributing to this trend. PM is classified based on its physical size, which ranges from PM10(diameter ≤10 μm) to PM2.5(≤2.5 μm) and PM0.5(≤0.5 μm). Smaller-sized PM can move freely through the air and readily infiltrate deep into the lungs, intensifying existing health issues and exacerbating complications. Lung complications are the most common issues arising from PM exposure due to the primary site of deposition in the respiratory system. Conditions such as asthma, COPD, idiopathic pulmonary fibrosis, lung cancer and various lung infections are all susceptible to worsening due to PM exposure. PM can epigenetically modify specific target sites, further complicating its impact on these conditions. Understanding these epigenetic mechanisms holds promise for addressing these complications in cases of PM exposure. This involves studying the effect of PM on different gene expressions and regulation through epigenetic modifications, including DNA methylation, histone modifications and microRNAs. Targeting and manipulating these epigenetic modifications and their mechanisms could be promising strategies for future treatments of lung complications. This review mainly focuses on different epigenetic modifications due to PM2.5exposure in the various lung complications mentioned above.

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Particulate matter-induced metabolic recoding of epigenetics in macrophages drives pathogenesis of chronic obstructive pulmonary disease

Cited by 4 publications

References 93 publications

SIRT1: An Intermediator of Key Pathways Regulating Pulmonary Diseases

SIRT1: An Intermediator of Key Pathways Regulating Pulmonary Diseases

Prenatal diagnosis and genetic counselling of a rare paternally inherited chromosome 2p21 microdeletion in a Chinese family

Particulate matter-induced epigenetic modifications and lung complications

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