Particulate matter pollution and non-targeted analysis of polar compounds in three regions of Brazil

Pozza, Simone A.; Gonçalves, Priscila B.; Wouters, Felipe C.; Vendemiatti, Josiane A.S.; Nogarotto, Danilo C.; Pereira-Filho, Edenir R.; Osório, Daniela M.M.; Romualdo, Lincoln L.; Godoi, Joeci R.; Hoinaski, Leonardo; Urban, Roberta C.

doi:10.1016/j.chemosphere.2023.139839

Cited by 4 publications

(1 citation statement)

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“…Pentachlorophenol is also a metabolite of other organochlorines, including the pesticide hexachlorobenzene(73) which has been associated with dairy consumption in Sweden. (74) Another common co-exposure (Group B, Figure S24 ) included homologues of polyethyleneglycol (Level 2, ICC 0-0.31, 36-100% DF), which are approved by the US Food and Drug Administration for dermal, oral and intravenous pharmaceutical applications,(75) and have been detected in environmental samples,(76,77) but not in human samples previously. Group C co-exposures ( Figure S23 ) included sodium lauryl sulfate (ICC 0.09, 45% DF, confirmed Level 1), strongly correlated with tetradecyl sulfate (Level 2; ICC 0.07, 36% DF; r 0.92, p < 0.001, n = 276, Figure 4B ) and lauryl diethanolamide (Level 2; ICC 0.01, 32% DF; r 0.66, p < 0.001, n = 276), all of which are ingredients in household cleaning and personal care products, such as detergents, shampoos, liquid soap and cosmetics.…”

Section: Resultsmentioning

confidence: 99%

Longitudinal Exposomics in a Multiomic Wellness Cohort Reveals Distinctive and Dynamic Environmental Chemical Mixtures in Blood

Sdougkou,

Papazian,

Bonnefille

et al. 2024

Preprint

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Chemical exposomes can now be comprehensively measured in human blood, but robust application of chemical exposomics in cohort studies requires knowledge of the longitudinal stability and interindividual variability of exogenous molecular profiles. Here we applied chemical exposomics to plasma of 46 adults, each sampled six times over two years in a multiomic wellness cohort. New chemicals were discovered, distinctive co-exposure patterns were observed, and intra-class correlation coefficients (ICC) for 519 confidently annotated substances are reported to support study design. Longitudinal stability of the chemical exposome (mean ICC 0.30) was significantly lower than the proteome, metabolome, lipidome or microbiome, and must be measured more frequently than other molecular profiles in health studies. Mixed-effects models nevertheless revealed significant associations between testosterone and perfluoroalkyl substances, and significant time-trends for low and high stability exposures alike. Complex exposome data structures were visualized and explored, demonstrating great potential for longitudinal exposomics in precision health research.

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