Particulate matter pollution associated with schizophrenia hospital re-admissions: a time-series study in a coastal Chinese city

Ji, Yanhu; Liu, Bin; Song, Jian; Pan, Rubing; Cheng, Jian; Su, Hong; Wang, Heng

doi:10.1007/s11356-021-14816-3

Cited by 18 publications

(9 citation statements)

References 32 publications

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“…136,137 Another study in a coastal city in China discovered a positive association between PM2.5 exposure and hospital readmission in SZ patients, with a stronger association in men and young adults (<45 years). 138 Furthermore, a case report including 1193 patients with SZ stated that ambient PM2.5 concentrations were associated with deterioration in SZ. 139 In this study, the stratified analysis by age group showed that the ORs associated with PM2.5 concentration increased substantially for patients over 65 years of age, and significant increases were observed at a single lag of 6 days.…”

Section: Pm25 and Mental Disordersmentioning

confidence: 99%

Neurodevelopmental toxicity induced by PM2.5 Exposure and its possible role in Neurodegenerative and mental disorders

et al. 2023

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Recent extensive evidence suggests that ambient fine particulate matter (PM2.5, with an aerodynamic diameter ≤2.5 μm) may be neurotoxic to the brain and cause central nervous system damage, contributing to neurodevelopmental disorders, such as autism spectrum disorders, neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, and mental disorders, such as schizophrenia, depression, and bipolar disorder. PM2.5 can enter the brain via various pathways, including the blood–brain barrier, olfactory system, and gut-brain axis, leading to adverse effects on the CNS. Studies in humans and animals have revealed that PM2.5-mediated mechanisms, including neuroinflammation, oxidative stress, systemic inflammation, and gut flora dysbiosis, play a crucial role in CNS damage. Additionally, PM2.5 exposure can induce epigenetic alterations, such as hypomethylation of DNA, which may contribute to the pathogenesis of some CNS damage. Through literature analysis, we suggest that promising therapeutic targets for alleviating PM2.5-induced neurological damage include inhibiting microglia overactivation, regulating gut microbiota with antibiotics, and targeting signaling pathways, such as PKA/CREB/BDNF and WNT/β-catenin. Additionally, several studies have observed an association between PM2.5 exposure and epigenetic changes in neuropsychiatric disorders. This review summarizes and discusses the association between PM2.5 exposure and CNS damage, including the possible mechanisms by which PM2.5 causes neurotoxicity.

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Section: Pm25 and Mental Disordersmentioning

confidence: 99%

Neurodevelopmental toxicity induced by PM2.5 Exposure and its possible role in Neurodegenerative and mental disorders

et al. 2023

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“…Additionally, subgroup analyses was performed to identify the susceptible groups based on gender (male and female) and age (< 45 years old and ≥ 45 years old) (Ji et al 2021). The effects of each extreme meteorological factor were also estimated for the warm season (April to September) and cold season (October to March) (Zhu et al 2017).…”

Section: ( )mentioning

confidence: 99%

Short-term effects of extreme meteorological factors on daily outpatient visits for anxiety in Suzhou, Anhui Province, China: a time series study

Zhang

Yang

et al. 2022

Environ Sci Pollut Res

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Anxiety disorders are a major public health concern in China. Previous studies have provided evidence for associations between ambient temperature and anxiety outpatient visits, but no studies have examined short-term effects of other meteorological factors such as sunshine duration, wind speed and precipitation on increased anxiety outpatient visits. We aimed to assess the association between climatic factors and outpatient visits for anxiety in Suzhou, a city with a temperate climate in Anhui Province, China. Daily anxiety outpatient visits, meteorological factors, and air pollutants from 2017 to 2019 were collected. A quasi-Poisson generalized linear regression model combined with distributed lag non-linear model (DLNM) was used to quantify the effects of extreme meteorological factors (sunshine duration, wind speed and precipitation) on anxiety outpatient visits. All effects were presented as relative risk (RR), with the 90th and 10th percentiles of meteorological factors compared to the median. Subgroup analyses by age and gender were performed to identify susceptible subgroups. A total of 11 323 anxiety outpatient visits were reported. Extremely low sunshine duration, low and high speed speed increased the risk of anxiety outpatient visits. The strongest cumulative effects occurred at lag 0-14 days, and the corresponding RRs of extremely low sunshine duration, low and high wind speed were 1.417 (95% CI: 1.056-1.901), 1.529 (95% CI: 1.028-2.275) and 1.396 (95% CI: 1.007-1.935), respectively. Subgroup analyses showed that males and people aged ≥ 45 years appeared to be more susceptible to the cumulative effects of extremely low sunshine duration. In addition, the adverse effects of extreme wind speed were more pronounced in the cold season. This study provides evidence that extreme climatic factors have a lagged effect on anxious outpatient visits. In the context of climate change, these ndings may help develop weather-based early warning systems to minimize the effects of extreme meteorological factors on anxiety.

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“…Work in 2021 increasingly turned to health service use data for estimating disorder prevalence, as a proxy of severity, for case identification, assessing the impact on mental health associated healthcare costs, and the role of air pollutants in mediating relapse. Of note, several studies explore emergency room visits [16,17], psychiatric hospital use [18][19][20][21][22][23] and outpatient mental health services [24][25][26][27] in relation to short-term air pollutant exposure for a range of affective, anxiety, cognitive and psychotic disorders and self-harm and suicide. Mixed findings for the associations among pollutant of interest, mental health outcome, and lag times, may relate to differences in location, ambient air pollutant levels, nonrandom underestimates of prevalence and incidence of mental health disorders by using health service user data, and differences in health systems and psychiatric care pathways.…”

Section: Epidemiological Associations Between Air Pollutants and Ment...mentioning

confidence: 99%

“…In recent months, limited evidence about the role of air pollutants and risk of relapse in chronic psychotic disorders has come from hospital attendance data [17,20]. In London, individuals living with schizophrenia made greater use of mental health services in the years following their first psychotic episode in line with greater PM2.5 exposures at the time of diagnosis [22].…”

Section: Psychosismentioning

confidence: 99%

Air pollution and mental health: associations, mechanisms and methods

King

Zhang

Cohen

2021

Current Opinion in Psychiatry

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Purpose of reviewThere is increasing interest in the links between exposure to air pollution and a range of health outcomes. The association with mental health however is much less established. This article reviews developments in the field over the past 12 months, highlighting the evidence for causation, associations between multiple air pollutants and mental health outcomes, and assesses the challenges of researching this topic. Recent findingsIncreasingly rigorous methods are being applied to the investigation of a broader range of mental health outcomes. These methods include basic science, neuroimaging, and observational studies representing diverse geographical locations. Cohort studies with linked high-resolution air pollutant exposure data are common, facilitating advanced analytic methods. To date, meta-analyses have demonstrated small and significant positive associations between long-term exposure to fine particulate matter and depressive symptoms and cognitive decline. Methodological complexities in measuring exposure and outcome pose ongoing difficulties for the field.

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Particulate matter pollution associated with schizophrenia hospital re-admissions: a time-series study in a coastal Chinese city

Cited by 18 publications

References 32 publications

Neurodevelopmental toxicity induced by PM2.5 Exposure and its possible role in Neurodegenerative and mental disorders

Neurodevelopmental toxicity induced by PM2.5 Exposure and its possible role in Neurodegenerative and mental disorders

Short-term effects of extreme meteorological factors on daily outpatient visits for anxiety in Suzhou, Anhui Province, China: a time series study

Air pollution and mental health: associations, mechanisms and methods

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