Partitioning of bio-active compounds from rinds of garcinia indica using aqueous two-phase system: Process evaluation and optimization

Nainegali, Basavaraj S.; Iyyaswami, Regupathi; Belur, Prasanna D.

doi:10.1016/j.seppur.2020.117520

Cited by 12 publications

(5 citation statements)

References 61 publications

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“…Both salting-out effects were the major driving force for the enrichment of solutes in the ethanol-rich phase (top phase), because increasing the salt concentration favored the recovery of proanthocyanins in the organic solvent. Nainegali, et al [164] studied the ATPS formed by 1-propanol/(NH 4 ) 2 SO 4 in the partitioning of bioactive compounds (anthocyanins, garcinol, isogarcinol, and hydroxy citric acid) from Garcinia indica peels. The authors identified that hydrophobic biomolecules (garcinol and isogarcinol) were partitioned to the alcohol-rich phase.…”

Section: Deep Eutetic Solvent (Des)-based Atpsmentioning

confidence: 99%

Aqueous Two-Phase Systems Based on Ionic Liquids and Deep Eutectic Solvents as a Tool for the Recovery of Non-Protein Bioactive Compounds—A Review

et al. 2022

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Aqueous two-phase systems (ATPS) based on ionic liquids (IL) and deep eutectic solvents (DES) are ecofriendly choices and can be used to selectively separate compounds of interest, such as bioactive compounds. Bioactive compounds are nutrients and nonnutrients of animal, plant, and microbial origin that benefit the human body in addition to their classic nutritional properties. They can also be used for technical purposes in food and as active components in the chemical and pharmaceutical industries. Because they are usually present in complex matrices and low concentrations, it is necessary to separate them in order to increase their availability and stability, and ATPS is a highlighted technique for this purpose. This review demonstrates the application of ATPS based on IL and DES as a tool for recovering nonprotein bioactive compounds, considering critical factors, results and the most recent advances in this field. In addition, the review emphasizes the perspectives for expanding the use of nonconventional ATPS in purification systems, which consider the use of molecular modelling to predict experimental conditions, the investigation of diverse compounds in phase-forming systems, the establishment of optimal operational parameters, and the verification of bioactivities after the purification process.

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Section: Deep Eutetic Solvent (Des)-based Atpsmentioning

confidence: 99%

Aqueous Two-Phase Systems Based on Ionic Liquids and Deep Eutectic Solvents as a Tool for the Recovery of Non-Protein Bioactive Compounds—A Review

et al. 2022

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“…To clarify, an aqueous two-phase system made up of 1-propanol (15.202% w/w) and (NH 4 ) 2 SO 4 (10.242% w/w) with 2.5 g crude load achieved the maximum yield of garcinol (97.39%) and isogarcinol (92.38%) in the top phase, anthocyanins (99.19%) and HCA (99.83%) in the bottom one with a purity higher than 99% by applying secondary aqueous two-phase system. 70 Furthermore, high-intensity ultrasound-assisted extraction for G. madruno increased the yield of bioflavonoids by ca . 3-fold (370 mg/100 mL of the total BF), 71 while cellulase-assisted extraction was applied for the direct and enhanced recovery of mangostins (potential xanthone compounds) from G. mangostana pericarps 72 which possess promising biological activities.…”

Section: Introductionmentioning

confidence: 99%

“…anthocyanins, garcinol, isogarcinol, and hydroxycitric acid. To clarify, an aqueous two-phase system made up of 1-propanol (15.202% w/w) and (NH 4 ) 2 SO 4 (10.242% w/w) with 2.5 g crude load achieved the maximum yield of garcinol (97.39%) and isogarcinol (92.38%) in the top phase, anthocyanins (99.19%) and HCA (99.83%) in the bottom one with a purity higher than 99% by applying secondary aqueous two-phase system . Furthermore, high-intensity ultrasound-assisted extraction for G. madruno increased the yield of bioflavonoids by ca .…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Garcinia cambogia Nutraceuticals in Relation to Its Hydroxy Citric Acid Level. A Comprehensive Review of Its Bioactive Production, Formulation, and Analysis with Future Perspectives

2022

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Garcinia cambogia (Gaertn.) Desr. (known as Malabar tamarind) is a popular traditional herbal medicine and is one of the well-known folk medicines reported for the treatment of obesity and incorporated in several nutraceuticals worldwide. These effects are mediated by a myriad of bioactive compounds with most effects attributed to its hydroxy citric acid (HCA) content. This review aims to present a holistic overview on novel trends in the production of G . cambogia bioactive components and how extraction optimization is important to ensure best product quality with its reported nanoformulations with particular emphasis on HCA content. Further, an overview of the different analytical approaches used for quality control assessment of G . cambogia plant and its nutraceuticals is presented highlighting both advantages and limitations. Moreover, analytical approaches for detecting G . cambogia metabolites in biological fluids with emphasis on HCA level to determine its pharmacokinetics and proof of efficacy are presented for the first time.

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“…Aqueous two‐phase systems (ATPS) have been widely used in separations of biomolecules such as proteins, polypeptides, enzymes 1–6, bioactive compounds 7, 8, and natural dyes 9–15, among others. Since both phases are mainly made up of water, they provide mild favorable conditions needed to preserve activities of biomolecules 16.…”

Section: Introductionmentioning

confidence: 99%

Anthocyanin Partition in Aqueous Two‐Phase Systems Based on Isopropanol and Sodium/Ammonium Sulfate

et al. 2022

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Partitioning of anthocyanins contained in the crude extract of Syzygium cumini fruit was investigated in aqueous two‐phase systems (ATPS) made up of isopropanol and Na2SO4/(NH4)2SO4. Na2SO4 induced ATPS formation more effectively than (NH4)2SO4. The increase in temperature enhanced phase separation in the (NH4)2SO4 ATPS, while the opposite occurred in the Na2SO4 ATPS. The higher the overall mixture concentration or temperature, the higher the values of tie‐line length and slope. In all systems and conditions, anthocyanins preferentially partitioned to the top phase. The partition coefficient and theoretical recovery yield in the top phase varied in the ranges 1.14–1.77 and 53.31–63.87 % in the (NH4)2SO4 ATPS, and in the ranges 1.94–21.50 and 65.90–95.55 % in the Na2SO4 ATPS.

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Partitioning of bio-active compounds from rinds of garcinia indica using aqueous two-phase system: Process evaluation and optimization

Cited by 12 publications

References 61 publications

Aqueous Two-Phase Systems Based on Ionic Liquids and Deep Eutectic Solvents as a Tool for the Recovery of Non-Protein Bioactive Compounds—A Review

Aqueous Two-Phase Systems Based on Ionic Liquids and Deep Eutectic Solvents as a Tool for the Recovery of Non-Protein Bioactive Compounds—A Review

Recent Advances in Garcinia cambogia Nutraceuticals in Relation to Its Hydroxy Citric Acid Level. A Comprehensive Review of Its Bioactive Production, Formulation, and Analysis with Future Perspectives

Anthocyanin Partition in Aqueous Two‐Phase Systems Based on Isopropanol and Sodium/Ammonium Sulfate

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