Partner Loss in Monogamous Rodents: Modulation of Pain and Emotional Behavior in Male Prairie Voles

Osako, Yoichi; Nobuhara, Reiko; Arai, Young‐Chang P.; Tanaka, Kenjiro; Young, Larry J.; Nishihara, Makoto; Mitsui, Shinichi; Yuri, Kazunari

doi:10.1097/psy.0000000000000524

Cited by 28 publications

(30 citation statements)

References 58 publications

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“…Based on our findings in 3.2 as well as on previous studies [21–26], we predicted that D-Phe treatment decreases emotionality. Therefore, we performed planned comparisons using t-tests.…”

Section: Resultssupporting

confidence: 72%

“…In male [21–26] as well as in non-lactating female prairie voles [23], separation from the partner results in increased anxiety-related behavior and passive stress-coping. Therefore, we predicted a similar outcome in the present study, and performed planned comparisons using t-tests.…”

Section: Resultsmentioning

confidence: 99%

“…Recently, prairie voles have been studied in terms of physiological and psychological consequences of partner-loss [21–26]. In males, separation from the pair-bonded female partner increases passive stress-coping, indicative of depressive-like behavior ([21, 27, 28] for review see [15, 29]), in conjunction with adrenal hypertrophy, higher basal levels of stress hormones as well as increased corticotropin-releasing factor (CRF) mRNA expression in the bed nucleus of the stria terminalis (BNST) [21] and CRF-immunoreactivity in the PVN [24].…”

Section: Introductionmentioning

confidence: 99%

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Abandoned prairie vole mothers show normal maternal care but altered emotionality: Potential influence of the brain corticotropin-releasing factor system

Bosch

Pohl

Neumann

et al. 2018

Behavioural Brain Research

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When fathers leave the family, mothers are at increased risk of developing depression and anxiety disorders. In biparental, socially monogamous prairie voles (Microtus ochrogaster), sudden bond disruption increases passive stress-coping, indicative of depressive-like behavior, and acts as chronic stressor in both males and females. However, the consequences of separation in lactating prairie vole mothers are unknown. In the present study, following 18 days of cohousing, half of the prairie vole pairs were separated by removing the male. In early lactation, maternal care was unaffected by separation, whereas anxiety-related behavior and passive stress-coping were significantly elevated in separated mothers. Separation significantly increased corticotropin-releasing factor (CRF) mRNA expression in the paraventricular nucleus of the hypothalamus under basal conditions, similar to levels of paired females after acute exposure to forced swim stress. A second cohort of lactating prairie voles was infused intracerebroventricularly with either vehicle or the CRF receptor antagonist D-Phe just prior to behavioral testing. The brief restraining during acute infusion significantly decreased arched back nursing in vehicle-treated paired and separated groups, whereas in the D-Phe-treated separated group the behavior was not impaired. Furthermore, in the latter, anxiety-related behavior and passive stress-coping were normalized to levels similar to vehicle-treated paired mothers. In conclusion, maternal investment is robust enough to withstand loss of the partner, whereas the mother's emotionality is affected, which may be - at least partly - mediated by a CRF-dependent mechanism. This animal model has potential for mechanistic studies of behavioral and physiological consequences of partner loss in single mothers.

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“…Based on our findings in 3.2 as well as on previous studies [21–26], we predicted that D-Phe treatment decreases emotionality. Therefore, we performed planned comparisons using t-tests.…”

Section: Resultssupporting

confidence: 72%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Abandoned prairie vole mothers show normal maternal care but altered emotionality: Potential influence of the brain corticotropin-releasing factor system

Bosch

Pohl

Neumann

et al. 2018

Behavioural Brain Research

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“…Males separated from their sibling do not show this social-loss-induced depressive behaviour or stress activation. Separation from a pair-bonded partner also results in heightened sensitivity to painful stimuli 118 .…”

Section: Oxytocin and Pair Bond Maintenancementioning

confidence: 99%

The neural mechanisms and circuitry of the pair bond

2018

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Love is one of our most powerful emotions, inspiring some of the greatest art, literature and conquests of human history. Although aspects of love are surely unique to our species, human romantic relationships are displays of a mating system characterized by pair bonding, likely built on ancient foundational neural mechanisms governing individual recognition, social reward, territorial behaviour and maternal nurturing. Studies in monogamous prairie voles and mice have revealed precise neural mechanisms regulating processes essential for the pairbond. Here, we discuss current viewpoints on the biology underlying pair bond formation, its maintenance and associated behaviours from neural and evolutionary perspectives.

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“…The neurobiology of grief is still in its infancy, but several seminal pieces of research have been conducted thus far. These have included functional neuroimaging, structural neuroimaging and even an animal model of bereavement (i.e., between monogamous, pair-bonded voles)(60,61).…”

Section: Adaptation Of the Brain During Griefmentioning

confidence: 99%

Grief: A Brief History of Research on How Body, Mind, and Brain Adapt

O’Connor

2019

Psychosom Med

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Objective: Using an integrative view of psychology, neuroscience, immunology and psychophysiology, the present review of literature curates the findings that have had an impact on the field of bereavement research, and shaped its development. Methods: Beginning with Lindemann’s systematic descriptions of medical and psychological responses to the death of a loved one, specific studies that investigate medical outcomes following loss, their psychological predictors, and biopsychosocial mechanisms are discussed. This selective review culminates in recommendations for the field for future research, including greater integration of these disparate fields of inquiry. Results: Morbidity and mortality following the death of a loved one has long been a topic of research. Early researchers characterized somatic and psychological symptoms and studied immune cell changes in bereaved samples. More recent research has repeatedly demonstrated increased rates of morbidity and mortality in bereaved samples, as compared to married controls, in large epidemiological studies. Recent developments also include the development of criteria for prolonged grief disorder (also termed complicated grief). Newer methods, including neuroimaging, have observed that the greatest impact of the death of a loved one is in those who have the most severe psychological grief reactions. Mechanisms tying bereavement to medical outcomes are scarce, but differences in rumination, in inflammation and in cortisol dysregulation between those who adapt well and those who do not, have been offered with some evidence. Conclusions: Recommendations to propel the field forward include longitudinal studies to understand differences between acute reactions and later adaptation, comparing samples with grief disorders from those with more typical responses, and integrating responses in brain, mind and body.

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Partner Loss in Monogamous Rodents: Modulation of Pain and Emotional Behavior in Male Prairie Voles

Cited by 28 publications

References 58 publications

Abandoned prairie vole mothers show normal maternal care but altered emotionality: Potential influence of the brain corticotropin-releasing factor system

Abandoned prairie vole mothers show normal maternal care but altered emotionality: Potential influence of the brain corticotropin-releasing factor system

The neural mechanisms and circuitry of the pair bond

Grief: A Brief History of Research on How Body, Mind, and Brain Adapt

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