This chapter will explore the various aspects of science diplomacy in the Mediterranean region, with a particular focus on the merging of political frameworks to strengthen it. The chapter will begin with an overview of science diplomacy in general and its importance in the Mediterranean region. It will then delve into the political frameworks that exist in the region and how they can be merged to create a more robust science diplomacy framework. This will involve examining key actors such as the European Union and its Southern Mediterranean neighbourhood. The chapter will then discuss the challenges that the Mediterranean region faces in achieving a successful science diplomacy framework. Finally, the chapter will look at the emerging programs for science diplomacy in the Mediterranean and their potential to enhance scientific collaboration and promote regional stability. Overall, the chapter will provide a comprehensive overview of science diplomacy, its challenges, and its potential for promoting cooperation and stability in the Mediterranean region.