2022
DOI: 10.3389/fpsyt.2022.913550
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Parvalbumin and parvalbumin chandelier interneurons in autism and other psychiatric disorders

Abstract: Parvalbumin (PV) is a calcium binding protein expressed by inhibitory fast-spiking interneurons in the cerebral cortex. By generating a fast stream of action potentials, PV+ interneurons provide a quick and stable inhibitory input to pyramidal neurons and contribute to the generation of gamma oscillations in the cortex. Their fast-firing rates, while advantageous for regulating cortical signaling, also leave them vulnerable to metabolic stress. Chandelier (Ch) cells are a type of PV+ interneuron that modulate … Show more

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Cited by 33 publications
(25 citation statements)
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“…Wnt signaling is known to be important for hippocampal functions 81 , as well as dysfunction in neurological disorders, such as spatial memory impairment and anxiety-like behavior 82 . Chandelier neurons and CA3 Glut neurons have been previously implicated in these neurological disorders 83, 84 , but whether our observed interactions between chandelier and CA3 Glut neurons are involved in these disorders awaits future investigations.…”
Section: Introductionmentioning
confidence: 82%
“…Wnt signaling is known to be important for hippocampal functions 81 , as well as dysfunction in neurological disorders, such as spatial memory impairment and anxiety-like behavior 82 . Chandelier neurons and CA3 Glut neurons have been previously implicated in these neurological disorders 83, 84 , but whether our observed interactions between chandelier and CA3 Glut neurons are involved in these disorders awaits future investigations.…”
Section: Introductionmentioning
confidence: 82%
“…As we have done with striatal cholinergic interneurons, (Gemperli et al, 2023) direct chemogenetic modulation of sensorimotor parvalbumin-positive interneurons can help determine whether their dysfunction can cause dystonia. Finally, noting that dysfunction of these neurons has also been observed in other conditions that commonly co-exist with CP like autism and epilepsy, (Dos Santos Rufino et al, 2023;Jiang et al, 2016;Juarez and Martínez Cerdeño, 2022;Påhlman et al, 2021) longitudinal characterization of social behavior, cognition, and seizure risk in this model of preterm birth would be valuable.…”
Section: Discussionmentioning
confidence: 99%
“…These defects, along with the observed alterations in the CINs electrophysiological properties (i.e., reduced intrinsic excitability), are associated with pyramidal neuron hyperexcitability (Zamboni et al, 2016(Zamboni et al, , 2018 and increased susceptibility to sporadic spontaneous and induced seizures. Notably, changes in the morphology and/or function of interneurons have been linked to neurological disorders (Juarez et al, 2022). Altered CIN development, activity, and lamination have been shown to result in an altered balance between excitation and inhibition, thereby contributing to neurological and cognitive disorders (e.g., epilepsy, autism spectrum disorders, Down syndrome, Rett syndrome, and schizophrenia) (Sanacora et al, 2000;Levitt et al, 2004;Levitt, 2005;Lewis et al, 2005;Rossignol, 2011;Penzes et al, 2013).…”
Section: Discussionmentioning
confidence: 99%
“…, reduced intrinsic excitability), are associated with pyramidal neuron hyperexcitability ( Zamboni et al, 2016 , 2018 ) and increased susceptibility to sporadic spontaneous and induced seizures. Notably, changes in the morphology and/or function of interneurons have been linked to neurological disorders ( Juarez et al, 2022 ). Altered CIN development, activity, and lamination have been shown to result in an altered balance between excitation and inhibition, thereby contributing to neurological and cognitive disorders ( e.g.…”
Section: Discussionmentioning
confidence: 99%