Parvovirus B19 Infection

Brown, Kevin E.; Young, Neal S.

doi:10.1007/978-1-4899-0036-4_20

Cited by 4 publications

(4 citation statements)

References 116 publications

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“…Our study showed lower seroprevalence of B19 antibodies among children and adolescents when compared with available data from India 9 . The pattern of seroprevalence in our study was consistent with that of developing Asian countries 4 12 and other tropical countries 5 13 14 , but lower than temperate countries 3 15 . This suggests that age of acquisition of parvovirus B19 infection may be slightly higher in tropical countries as compared to temperate countries 12 16 .…”

supporting

confidence: 87%

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Seroepidemiology of parvovirus B19 among different age groups & pregnant women in India

Viswanathan

Tandale

Tamayachekar

et al. 2017

Indian Journal of Medical Research

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supporting

confidence: 87%

“…Parvovirus B19 (B19) can infect people of all ages, regions and social groups 1 2 3 . Infection patterns in tropical and temperate countries, however, are variable 4 5 . Clinical presentation also varies depending on age, immune status and presence of underlying diseases.…”

mentioning

confidence: 99%

Seroepidemiology of parvovirus B19 among different age groups & pregnant women in India

Viswanathan

Tandale

Tamayachekar

et al. 2017

Indian Journal of Medical Research

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“…Severe thrombocytopenia and pancytopenia have also been reported to be caused by B19 infection [Young, 1988;Brown and Young, 1995]. We therefore included a panel of 22 sera from patients with anemia, thrombocytopenia, or pancytopenia in this study (group 4).…”

Section: Prevalence Of Ns1-specific Igg In Patients Withmentioning

confidence: 99%

Seroprevalence of parvovirus B19 NS1-specific IgG in B19-infected and uninfected individuals and in infected pregnant women

Hemauer

Gigler

Searle³

et al. 2000

J. Med. Virol.

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Parvovirus B19 is the causative agent of erythema infectiosum in children, but the virus is associated with an increasing range of different diseases. These include acute and chronic arthritis, hydrops fetalis in pregnant women, aplastic anemia, and thrombocytopenia. The host's immune response is directed against the viral structural proteins VP1 and VP2. This study investigated the presence of IgG against the viral nonstructural protein NS1 using Western blot. Serum panels from healthy individuals, B19-infected pregnant women, and various disease groups were tested. The disease groups included patients with symptoms that may be linked to parvovirus B19 infection. The results showed that IgG against the NS1 protein was present in 22% of healthy individuals with past B19 infection. In cases of persistent or prolonged B19 infections, the prevalence of NS1-specific antibodies was as high as 80%. It is concluded that NS1-specific IgG may be used as an indicator of chronic or more severe courses of parvovirus B19 infections.

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“…The condition is an acutely acquired type of pure red cell aplasia which results from a maturation arrest of bone marrow erythroid precursor cells at the pronormoblast/ early normoblast stage. The majority of cases are associated with infection by the parvovirus B19 (26), although other pathogens have been reported to cause a similar illness (27). The only parvovirus known to be pathogenic in humans, B19 replicates exclusively in the bone marrow red cell precursors.…”

Section: Aplastic Crisismentioning

confidence: 99%

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1998

European J of Haematology

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The management of crisis in sickle cell disease Okpala I. The management of crisis in sickle cell disease.Eur J Haematol 1998: 60: 1-6. 0 Munksgaard 1998. Abstract: The symptoms and signs of sickle cell disease are exacerbated in times of crisis, characterized by tissue infarction or worsening anaemia. Prompt medical intervention is required in these distressing situations to provide relief and comfort to the patient. Effective analgesia is crucial in treating the painful crisis of sickle cell disease. The haemoglobinopathy may cause hyposthenuria with reduced ability to excrete the sodium load in normal saline. A 5% dextrose solution or 5% dextrose in 25% normal saline is therefore recommended for intravenous hydration. As the leading cause of morbidity and mortality in sickle cell disease, infections call for vigorous antibiotic therapy. Oxygen administration should be reserved for hypoxic patients, and blood transfusion given only when really indicated. Acute chest syndrome and cerebrovascular accidents are life-threatening complications of sickle cell disease whereas priapism can cause important long-term sequelae; all deserve urgent attention. In the long term, comprehensive care is cost-effective in reducing the frequency and adverse effects of sickle cell I crisis.The first recorded description of the crisis now recognized as a feature of sickle cell disease was by Africanus Horton, who noted the bone pains and the association with fever and cold weather (1). The illness must have sustained the interest of medical scientists because by the beginning of this century Herrick had discovered the cellular basis of painful crisis (2) and, 75 years after Horton's account, sickle cell anaemia became the first human disease to be described at the molecular level (3). Haemoglobin S (HbS) is the result of a point mutation in the sixth codon of the P-globin gene (GAT+G?T), so that the 6th amino acid in P-globin is valine instead of glutamic acid, as found in normal haemoglobin (HbA). Sickle cell disease (SCD) is a generic term which includes sickle cell anaemia (HbSS), sickle cell haemoglobin C disease (HbSC), sickle cell thalassqemia disease (Shhal) and other compound heterozygous conditions which have in common the inheritance of the sickle P-globin gene and also cause clinical disease. It does not include sickle cell trait (HbAS). With the facility of modern travelling, human societies in various parts of the globe are becoming more lheanyi Okpala

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Parvovirus B19 Infection

Cited by 4 publications

References 116 publications

Seroepidemiology of parvovirus B19 among different age groups & pregnant women in India

Seroepidemiology of parvovirus B19 among different age groups & pregnant women in India

Seroprevalence of parvovirus B19 NS1-specific IgG in B19-infected and uninfected individuals and in infected pregnant women

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