Parvovirus B19 infection in adult patients after allogeneic stem cell transplantation: our experience of five cases and literature review

Katoh, Daisuke; Ochi, Yotaro; Hiramoto, Nobuhiro; Morita, Mari; Yabushita, Tomohiro; Shimomura, Yoshimitsu; Yamashita, Daisuke; Ono, Yoshio; Yoshioka, Satoshi; Yonetani, Noboru; Matsushita, Akiko; Imai, Yukihiro; Hashimoto, Hisako; Ishikawa, Takayuki

doi:10.1038/s41409-019-0533-1

Cited by 11 publications

(19 citation statements)

References 15 publications

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“…Regarding HSCT recipients, rash, cytopenia, and arthralgia were observed in 50%, 50%, and 11%, respectively, of 28 allo-HSCT recipients infected with B19V that were identified by literature review (229). Most patients developed a rash early after HSCT (Յ3 months), whereas anemia occurred later after HSCT (Ͼ3 months).…”

Section: Dna Viruses Double-stranded Dna Virusesmentioning

confidence: 99%

Beyond Cytomegalovirus and Epstein-Barr Virus: a Review of Viruses Composing the Blood Virome of Solid Organ Transplant and Hematopoietic Stem Cell Transplant Recipients

2020

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SUMMARY Viral primary infections and reactivations are common complications in patients after solid organ transplantation (SOT) and hematopoietic stem cell transplantation (HSCT) and are associated with high morbidity and mortality. Among these patients, viral infections are frequently associated with viremia. Beyond the usual well-known viruses that are part of the routine clinical management of transplant recipients, numerous other viral signatures or genomes can be identified in the blood of these patients. The identification of novel viral species and variants by metagenomic next-generation sequencing has opened up a new field of investigation and new paradigms. Thus, there is a need to thoroughly describe the state of knowledge in this field with a review of all viral infections that should be scrutinized in high-risk populations. Here, we review the eukaryotic DNA and RNA viruses identified in blood, plasma, or serum samples of pediatric and adult SOT/HSCT recipients and the prevalence of their detection, with a particular focus on recently identified viruses and those for which their potential association with disease remains to be investigated, such as members of the Polyomaviridae, Anelloviridae, Flaviviridae, and Astroviridae families. Current knowledge of the clinical significance of these viral infections with associated viremia among transplant recipients is also discussed. To ensure a comprehensive description in these two populations, individuals described as healthy (mostly blood donors) are considered for comparative purposes. The list of viruses that should be on the clinicians’ radar is certainly incomplete and will expand, but the challenge is to identify those of possible clinical significance.

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Section: Dna Viruses Double-stranded Dna Virusesmentioning

confidence: 99%

Beyond Cytomegalovirus and Epstein-Barr Virus: a Review of Viruses Composing the Blood Virome of Solid Organ Transplant and Hematopoietic Stem Cell Transplant Recipients

2020

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“…Though the detected DNA in blood might also be non-infectious naked DNA sipping out from the injured tissues, the high titer indicated that the DNA detected by real-time PCR is more likely from replicating virus. In addition, the discovery of B19V DNA and various bacteria in BALF can confirm that it is at least partly directly related to pneumonia ( 23 – 25 ). Due to convulsions during the course of the disease, lumbar puncture, and CSF mNGS detection also revealed B19V.…”

Section: Discussionmentioning

confidence: 87%

“…He had no long-term immunosuppression, history of exposure to chemicals, poisons, animals, or other underlying conditions that can cause a state of immunosuppression. Meanwhile, there are few B19V involving multiple systems and accompanied by multiple organ failure ( 12 , 23 ). The possibility of B19V infection is rarely considered in routine pathogen screening.…”

Section: Discussionmentioning

confidence: 99%

“…The clinical manifestations caused by B19V infection are diverse. Still, few reports involve multiple organ or even concurrent central nervous system infection ( 23 ), and the rarity of B19V infection brings difficulties in diagnosis. Clinicians should pay attention to the immune status of patients in the disease state and rationally use mNGS technology to assist clinical diagnosis.…”

Section: Discussionmentioning

confidence: 99%

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Multisystem Involvement Induced by Human Parvovirus B19 Infection in a Non-immunosuppressed Adult: A Case Report

Zou

Chen

et al. 2022

Front. Med.

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BackgroundHuman parvovirus B19 (B19V) infection is usually symptomless and occurs in the childhood. While in immunocompromised adults, B19V infection also presents various clinical symptoms due to the host's immune status. The classic symptoms include erythema, anemia, arthropathy, and edema, but neurological involvement is rare.Case PresentationIn this report, we present a case of B19V infection caused multiple organ dysfunction in a non-immunosuppressed adult. Metagenomic next-generation sequencing (mNGS) was used and successfully detected the pathogen in multiple types of samples, including blood, cerebrospinal fluid (CSF), and bronchoalveolar lavage fluid (BALF). The diagnosis was subsequently confirmed by polymerase chain reaction (PCR). He was treated with intravenous gamma globulin, resulting in a significant resolution of symptoms after 1 month.ConclusionMultisystem involvement induced by B19V infection was found in this case report. mNGS performed great advantages in rapidly and accurately diagnosing B19V infection in multiple types of samples, which helps the timely adjustment of treatment and improves the prognosis.

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“…The time of the onset of PVB19 disease range from 0.03 to 96 months after HSCT. Rash and cytopenia are the main manifestations of PVB19 infection (26/32 cases) [12][13][14][15][16], followed by other symptoms including arthralgia, malaise, headache, myalgia, and pruritus [17][18][19][20][21][22][23][24]. Four of the 32 patients developed organ failure involving the heart, the lungs, or the kidneys [21,24],among which three patients also had cytopenia.…”

Section: Discussionmentioning

confidence: 99%

Precisione Treatment for Parvovirus B19 Infection After Hematopoietic Stem Cell Transplantation: a Case Report and Review of the Literature

Zhou

Wang

et al. 2021

Preprint

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Background: Cytopenia due to parvovirus B19 (PVB19) infection has rarely been reported in recipients of thalassemia major after hematopoietic stem cell transplantation (HSCT). Most of the reported cases were patients undergone solid organ transplantation, especially renal transplant. However, cases of pediatric patients in thalassemia major have rarely been reported. Case presentation: Here we report a girl that had PVB19-induced anemia while undergoing immunosuppressive therapy after transplant. The patient presented with progressive anemia and had a lowest hemoglobin level of 58 g/L. Bone marrow biopsy showed suppress inhibited erythropoiesis with giant pronormoblasts. Next-generation sequencing of peripheral blood suggested the infection of PVB19.The detection of serum PVB19-DNA using quantitative polymerase chain reaction revealed a viral load of over 1×108 copies/ml. The hemoglobin level increased to 113 g/L after six courses of intravenous immunoglobulin (IVIG) therapy. Monitoring of viral load showed PVB19-DNA level remained at a low level for six months before clearance. Pure red cell aplasia was not observed during the treatment period. Conclusions: Our case suggests that timely and adequately diagnosis and treatment against PVB19 with IVIG is effective and may prevent sequential complications in pediatric HSCT recipients.

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Parvovirus B19 infection in adult patients after allogeneic stem cell transplantation: our experience of five cases and literature review

Cited by 11 publications

References 15 publications

Beyond Cytomegalovirus and Epstein-Barr Virus: a Review of Viruses Composing the Blood Virome of Solid Organ Transplant and Hematopoietic Stem Cell Transplant Recipients

Beyond Cytomegalovirus and Epstein-Barr Virus: a Review of Viruses Composing the Blood Virome of Solid Organ Transplant and Hematopoietic Stem Cell Transplant Recipients

Multisystem Involvement Induced by Human Parvovirus B19 Infection in a Non-immunosuppressed Adult: A Case Report

Precisione Treatment for Parvovirus B19 Infection After Hematopoietic Stem Cell Transplantation: a Case Report and Review of the Literature

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