Parvovirus B19 Infection in Hashimoto's Thyroiditis, Papillary Thyroid Carcinoma, and Anaplastic Thyroid Carcinoma

Adamson, Laura; Fowler, Larry J.; Clare‐Salzler, Michael; Hobbs, Jacqueline A.

doi:10.1089/thy.2010.0307

Cited by 52 publications

(38 citation statements)

References 35 publications

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“…1 In children, B19 infection is generally associated with erythema infectiosum ("slapped cheek" or fifth disease). 1,2 In immunocompromised or hemolytic subjects, clinical manifestations following B19 infection include polyarthropathy, 3 hematological disorders, such as red cell aplasia and chronic anemia, 4 thrombocytopenia 5 and neutropenia, 6 myocarditis, 7 hepatitis, 8 neurologic diseases, [9][10][11] hyperthyroidism and thyroid cancer pathogenesis/progression, 12,13 glomerulonephritis, 14,15 and systemic lupus erythematosus. 16 On the whole, B19 infection may lead to disorders exhibiting striking similarities with systemic autoimmune diseases, and can be associated with elevated serum autoantibody titers.…”

Section: Introductionmentioning

confidence: 99%

Selfness-nonselfness in designing an anti-B19 erythrovirus vaccine

Fasano

Kanduc²

2011

Self/Nonself

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Section: Introductionmentioning

confidence: 99%

Selfness-nonselfness in designing an anti-B19 erythrovirus vaccine

Fasano

Kanduc²

2011

Self/Nonself

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“…There have been 3 case studies and a fourth group study linking thyroid diseases with B19 [33][34][35][36]. Our laboratory and others have shown that B19 infects the thyroid [37][38][39]. The thyroid's critical role in early neurological development may be altered by B19 infections [40].…”

Section: Infection Of Other Organs and Its Resulting Effect On Brainmentioning

confidence: 99%

How Do Viruses Really Cause Neuropathology?: Is There More to the Story

Hobbs¹,

Waseem²

2016

J Neuroinfect Dis

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Our work has focused over the years on Primate Erythroparvovirus 1 [more commonly known as parvovirus B19 (B19)]. B19 is a human pathogen that is the causative agent of erythema infectiosum, the common rash disease of childhood. In addition to several other human diseases, B19 has also been associated with multiple brain diseases. Those brain diseases include, but are not limited to, encephalitis, encephalopathy, meningitis, meningoencephalitis, ataxia, seizures, and stroke. To date, the association has grown, but causation has not been determined. Several possible mechanisms of pathogenesis including direct infection, indirect/epigenetic, reactivation, and autoimmune/ inflammatory cytotoxicity, as well as effects due to infection of other organs have been suggested. We will also offer other hypotheses.

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“…Herpes simplex virus type 2 was found to be significantly associated with papillary thyroid cancer and the presence of lymph node metastases [22]. Furthermore, human parvovirus B19 has been frequently present in thyroid tissues of Hashimoto’s thyroiditis and papillary thyroid cancer [23]. Although the thyroid gland is one of the CMV reservoirs [12,13], no previous study has examined the presence of CMV in thyroid cancer.…”

Section: Discussionmentioning

confidence: 99%

No evidence of association between human cytomegalovirus infection and papillary thyroid cancer

2014

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BackgroundHuman cytomegalovirus (CMV) has been detected in the thyroid gland and thyroid tumors. CMV infection may activate the mitogen-activated protein kinase pathway, of which aberrant activation is frequently associated with BRAF mutation in papillary thyroid cancer.MethodsA total of 45 paired tumorous and adjacent non-neoplastic tissue samples, including 5 follicular adenoma and 40 papillary thyroid cancer, were obtained during thyroidectomy. BRAF mutational status was determined using direct sequencing. The presence of CMV DNA was determined using conventional PCR and quantitative real-time PCR. CMV protein in the tissue samples were evaluated with Western blot analysis.ResultsBRAF mutation was identified in the cancerous part of 31 (78%) papillary thyroid cancers. Papillary cancer with BRAF mutation was significantly associated with a larger tumor size (P = 0.045), extrathyroidal invasion (P = 0.012), lymph node metastasis (P = 0.008), and a higher TNM stage (P = 0.044). CMV DNA and protein were not detected in any studied samples.ConclusionsOur results suggest no association between CMV infection and papillary thyroid cancer.

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Parvovirus B19 Infection in Hashimoto's Thyroiditis, Papillary Thyroid Carcinoma, and Anaplastic Thyroid Carcinoma

Cited by 52 publications

References 35 publications

Selfness-nonselfness in designing an anti-B19 erythrovirus vaccine

Selfness-nonselfness in designing an anti-B19 erythrovirus vaccine

How Do Viruses Really Cause Neuropathology?: Is There More to the Story

No evidence of association between human cytomegalovirus infection and papillary thyroid cancer

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