Parvovirus infection mimicking systemic lupus erythematosus

Cooray, Mohan; Manolakos, Joshua J.; Wright, Douglas; Haider, Shariq; Patel, Ameen

doi:10.1503/cmaj.121565

Cited by 13 publications

(7 citation statements)

References 16 publications

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“…Facial (malar) rash and joint pain and swelling, even angioedema, are features of systemic lupus erythematosus (SLE), and B19V may mimic the clinical presentation of SLE (908)(909)(910)(911)(912). In a few cases, B19V infection seemed to be followed by the development of SLE (913), although misdiagnosis of B19V arthropathy with the more serious autoimmune disease seems possible in retrospect (824,(913)(914)(915).…”

Section: Clinical Manifestations Diseases Caused By B19v Infectionmentioning

confidence: 99%

Human Parvoviruses

2017

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Parvovirus B19 (B19V) and human bocavirus 1 (HBoV1), members of the large Parvoviridae family, are human pathogens responsible for a variety of diseases. For B19V in particular, host features determine disease manifestations. These viruses are prevalent worldwide and are culturable in vitro, and serological and molecular assays are available but require careful interpretation of results. Additional human parvoviruses, including HBoV2 to -4, human parvovirus 4 (PARV4), and human bufavirus (BuV) are also reviewed. The full spectrum of parvovirus disease in humans has yet to be established. Candidate recombinant B19V vaccines have been developed but may not be commercially feasible. We review relevant features of the molecular and cellular biology of these viruses, and the human immune response that they elicit, which have allowed a deep understanding of pathophysiology.

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Section: Clinical Manifestations Diseases Caused By B19v Infectionmentioning

confidence: 99%

Human Parvoviruses

2017

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“…En pacientes inmunocompetentes, la producción de anticuerpos específicos para el B19 resulta en el clearance de la viremia en pocos días. En pacientes inmunocomprometidos o en quienes usan drogas inmunosupresoras, el virus persiste debido a una alteración en la producción de anticuerpos y deficiente depuración de la viremia [4][5][6][7][8][9][10][11][12] .…”

Section: Discussionunclassified

“…La presencia del PBV19 se relacionó además con hipocomplementemia, niveles elevados de ANA, anti-DNAdc y anticuerpos anticitoplasma de neutrófilo. Por esto, se le ha atribuido la causalidad de algunas enfermedades autoinmunes como artritis, vasculitis y LES 6,7 . La infección por PVB19 puede ser sólo una coincidencia en el diagnóstico diferencial del LES, un factor etiológico o un desencadenante.…”

Section: Discussionunclassified

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Lupus eritematoso sistémico y parvovirus. ¿Relación causal?

Gárate

Balcazar

Yucra

et al. 2018

Rev. Argent. Reumatol.

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El lupus eritematoso sistémico (LES) es una enfermedad autoinmune de etiología aún desconocida, afecta a individuos genéticamente predispuestos. Es desencadenado por factores hormonales, estrogénicos, ambientales y virales como hepatitis B/C, citomegalovirus (CMV), herpes o parvovirus B19 (PVB19). El PVB19 puede afectar diferentes órganos y presentar manifestaciones clínicas e inmunológicas, similares a las que se observan en pacientes con LES. Se han descripto alteraciones inmunológicas hasta en 79% de los pacientes con infección asociada por PVB19, principalmente positivización de anticuerpos antinucleares (ANA).

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“…Infectious agents are proposed to act as triggers for autoimmunity ("viral hypothesis" [1] ). PVB19 manifestations sometimes show intriguing similarities to SLE [2,3] . We describe the case of a 25-yearold critically ill woman presenting PVB19 primary infection and concomitant inaugural SLE flare-up.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Presentation of Parvovirus B19 Infection and Systemic Lupus Erythematosus in a Patient: Description and Review of the Literature

Chabert

Kallel

2020

European Journal of Case Reports in Internal Medicine

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We present the case of a 25-year-old woman without medical history, presenting with acute respiratory failure needing mechanical ventilation. Aetiologic screening showed PVB19 primary infection and concomitant SLE flare-up. We discuss the causative interactions between PVB19 and SLE in the pathogenesis of the disease. Difficulty diagnosing inaugural SLE flare-up concomitant with PVB19 infection can lead to delayed diagnosis and treatment. Inversely, overtreating a SLE-mimicking PVB19 infection with immunosuppressive agents can be highly detrimental.

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Parvovirus infection mimicking systemic lupus erythematosus

Cited by 13 publications

References 16 publications

Human Parvoviruses

Human Parvoviruses

Lupus eritematoso sistémico y parvovirus. ¿Relación causal?

Simultaneous Presentation of Parvovirus B19 Infection and Systemic Lupus Erythematosus in a Patient: Description and Review of the Literature

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