Parvovirus Variation for Disease: A Difference with RNA Viruses?

López-Bueno, Alberto; Villarreal, Luis P.; Almendral, José M.

doi:10.1007/3-540-26397-7_13

Cited by 42 publications

(46 citation statements)

References 89 publications

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“…This is typical for parvovirus population sequence data [34,35]. The MDPV identified in this study, UDAYANA-MDPA and -MDPB, are typical MDPV in that they share a common cluster with all worldwide MDPV strains and are distinctly separated from GPV.…”

Section: Discussionsupporting

confidence: 60%

Muscovy Duck Parvovirus Infection with Epicarditis in Bali, Indonesia

Mahardika¹,

Putra²,

Dewi³

et al. 2015

J Veterinar Sci Technol

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Muscovy duck parvovirus (MDPV) is threatening industry and backyard Muscovy duck poultry throughout the world. Here, we confirmed its presence in Indonesia for the first time. The outbreak described in this study occurred in a small fatty liver (French: foie gras) industry in Tabanan, Bali, and affected ducklings aged 2-3 weeks. Although older Muscovy ducks were present at the facility, they did not present signs of illness. Among the ducklings, the morbidity and mortality rates were 100% and 90%, respectively. The initial incidence began on 15 June 2014 and ended a month later. It reoccurred in January 2015. Clinical signs were lethargy, anorexia, watery diarrhoea, and dyspnea. The most frequent pathological lesions were cardiac enlargement with pale pericardia, haemorrhage, and enlargement of the liver. Dominant histopathology features were severe enteritis, epicarditis, and hepatitis. Using polymerase chain reaction (PCR) and published primer pairs NS1/REP and VP1, MDPV infection was confirmed with whole DNA isolated from the heart and liver homogenates. Sequencing of the PCR products resulted in 900 bp NS1/REP and 1200 bp VP1 fragments specific to MDPV. The virus sequences from the two separated incidences were completely homologous with one another. Now that MDPV has been detected in Indonesia, it should be included in the differential diagnosis when evaluating ducklings with MDPV-associated symptoms.

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Section: Discussionsupporting

confidence: 60%

Muscovy Duck Parvovirus Infection with Epicarditis in Bali, Indonesia

Mahardika¹,

Putra²,

Dewi³

et al. 2015

J Veterinar Sci Technol

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“…It has been recently speculated by others (Ló pez-Bueno et al, 2003;Shackelton & Holmes, 2006) that the fidelity and the proofreading activity of the enzymic complex containing the host DNA polymerase, recruited cellular replication factors and the viral NS1 protein may not be as efficient in single-stranded DNA viruses as expected so far. Furthermore, it has been demonstrated that B19V, similar to parvoviruses infecting animals, has a high rate of evolutionary changes that is more typical of RNA viruses (Ló pez- Bueno et al, 2006;Shackelton et al, 2005;Shackelton & Holmes, 2006). Since the NS1 gene evolves at a similar rate as the gene for VP2, it was suggested that immune selection is not the primary cause of the high substitution rate in B19V.…”

Section: Discussionmentioning

confidence: 99%

Simultaneous persistence of multiple genome variants of human parvovirus B19

Schneider

Höne

Tolba

et al. 2008

Journal of General Virology

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The species human parvovirus B19 (B19V) can be divided into three genotypes. In this study, we addressed the question as to whether infection of an individual is restricted to one genotype. As viral DNA is detectable in tissue for long times after acute infection, we examined 87 liver specimens from adults for the presence of B19V DNA. Fifty-nine samples were found to be positive, 32 of them for genotype 1, 27 for genotype 2 and four for genotype 3. In four samples, DNA of two genotypes was detected; samples from three individuals were positive for genotypes 1 and 2 and a sample from one individual was positive for genotypes 1 and 3. Surprisingly, significant sequence heterogeneity was observed at approximately 1 % of the nucleotides of the genotype 1 genomes from individuals with double genotype 1 and 2 infection. Controls using different enzymes for genome amplification and dilutions of the template verified that nucleotide heterogeneity was due to the presence of three or more genome variants of genotype 1. In summary, the evidence shows that individuals can be infected with two different genotypes, and B19V DNA can persist as a population of different genomes. The results may have implications for the understanding of the antiviral immune response and the development of vaccines against B19V.

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“…Several studies have indicated that recombination contributes to geminivirus diversity (48,60,71). However, unlike doublestranded DNA (dsDNA) viruses, there is also mounting evidence that ssDNA viruses are subject to high nucleotide mutation rates similar to the levels reported previously for RNA viruses (34,35,53). Thus, geminiviruses represent a unique opportunity to examine the processes that contribute to the genetic variation of ssDNA viruses as well as the mechanisms underlying virus evolution in plants.…”

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confidence: 99%

High-Frequency Reversion of Geminivirus Replication Protein Mutants during Infection

Argüello‐Astorga

Ascencio-Ibáñez

Dallas

et al. 2007

J Virol

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The geminivirus replication protein AL1 interacts with retinoblastoma-related protein (RBR), a key regulator of the plant division cell cycle, to induce conditions permissive for viral DNA replication. Previous studies of tomato golden mosaic virus (TGMV) AL1 showed that amino acid L148 in the conserved helix 4 motif is critical for RBR binding. In this work, we examined the effect of an L148V mutation on TGMV replication in tobacco cells and during infection of Nicotiana benthamiana plants. The L148V mutant replicated 100 times less efficiently than wild-type TGMV in protoplasts but produced severe symptoms that were delayed compared to those of wild-type infection in plants. Analysis of progeny viruses revealed that the L148V mutation reverted at 100% frequency in planta to methionine, leucine, isoleucine, or a second-site mutation depending on the valine codon in the initial DNA sequence. Similar results were seen with another geminivirus, cabbage leaf curl virus (CaLCuV), carrying an L145A mutation in the equivalent residue. Valine was the predominant amino acid recovered from N. benthamiana plants inoculated with the CaLCuV L145A mutant, while threonine was the major residue in Arabidopsis thaliana plants. Together, these data demonstrated that there is strong selection for reversion of the TGMV L148V and CaLCuV L145A mutations but that the nature of the selected revertants is influenced by both the viral background and host components. These data also suggested that high mutation rates contribute to the rapid evolution of geminivirus genomes in plants.

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Parvovirus Variation for Disease: A Difference with RNA Viruses?

Cited by 42 publications

References 89 publications

Muscovy Duck Parvovirus Infection with Epicarditis in Bali, Indonesia

Muscovy Duck Parvovirus Infection with Epicarditis in Bali, Indonesia

Simultaneous persistence of multiple genome variants of human parvovirus B19

High-Frequency Reversion of Geminivirus Replication Protein Mutants during Infection

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