Parvoviruses: agents of distinct pathogenic and molecular potential

Siegl, G.; Tratschin, Jon-Duri

doi:10.1111/j.1574-6968.1987.tb02479.x

Cited by 16 publications

(4 citation statements)

References 107 publications

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“…From previous in viva (ROTH et al, 1984) and in vitro (KAADEN et al, 1986) studies we had evidence that ADV replicates in B cell-enriched fractions. It is expected to affect certain subpopulation(s) of the B-cell line and not the mature plasma cell, since in analogy to other autonomous parvoviruses ADVbeside intracellular, presumably differentiation-dependent factorsessentially depends from proliferating cells for efficient replication (COTMORE and TAT- TERSALL, 1987;SIEGL and TRATSCHIN, 1987). This is in agreement with our failure to detect viral antigen immunohistologically in cells with a morphology of mature plasma cells.…”

Section: Virological Findingssupporting

confidence: 87%

Violet Mink Develop an Acute Disease after Experimental Infection with Aleutian Disease Virus (ADV) Isolate ADV SL3

Haas

Wohlsein

Trautwein

et al. 1990

Journal of Veterinary Medicine, Series B

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Summary Six‐Aleutian (aa)‐genotype violet mink were infected intraperitoneally with the Aleutian Disease Virus (ADV) bone marrow derived isolate ADV SL3. All animals developed virus‐specific antibodies and hypergammaglobulinaemia. Mortality during the fourteen week duration of the infection was 50%. The virus induced (histo)pathological lesions typical for Aleutian Disease. By immunohistochemical examination using a virus capsid‐specific monoclonal antibody viral antigen was detected in lymph nodes, spleen, kidneys and once in hepatic Kupffer cells. By Southern blot and in situ hybridization studies with strand‐specific RNA probes able to distinguish viral replicative forms from merely sequestered genomic DNA, ADV replication was detected in mesenteric lymph nodes and spleen. In one mink DNA replicative forms were also found in bone marrow cells or mononuclear cells of the peripheral blood, respectively. Only single‐stranded viral DNA was detected in liver, kidney, gut and lung of infected animals. From Southern blot hybridization results a different, possibly organ‐specific permissiveness of ADV in vivo is suggested. Zusammenfassung Akute Erkrankung von Aleuten‐Genotyp‐Nerzen nach experimenteller Infektion mit dem Aleutian Disease Virus (ADV)‐Isolat ADV SL3 Sechs Aleutian(aa)‐Genotyp‐Nerze wurden mit dem Aleutian Disease Virus (ADV)‐Knochen‐markisolat ADV SL3 intraperitoneal infiziert. Alle Tiere serokonvertierten und entwickelten eine Hypergammaglobulinämie. Die Mortalität innerhalb der 14wöchigen Versuchsdauer betrug 50%. Das Virus induzierte Aleutian Disease‐typische (histo)pathologische Alterationen. Aufgrund immunhistochemischer Untersuchungen mit einem Viruskapsid‐spezifischen monoklonalen Antikörper wurde virales Antigen in Lymphknoten, Milz und Nieren, sowie einmal in Kupfferschen Sternzellen der Leber gefunden. Mittels Southern blot‐ und in situ‐Hybridisierungen mit strangspezifischen RNA‐Sonden, die eine Diskriminierung virusreplikativer von (sequestrierter) viraler Genom‐DNA erlaubten, konnte eine effiziente Virusvermehrung in mesenterialen Lymphknoten sowie Milz nachgewiesen werden. Bei je einem Nerz gelang dieser Nachweis auch in Knochenmarkzellen sowie in mononukleären Zellen des peripheren Blutes. In Leber, Niere, Darm und Lunge waren replikative DNA‐Formen nicht nachweisbar. Aufgrund der Southern blot‐Hybridisierungen ergaben sich Hinweise für eine differente, eventuell organspezifische Permissivität von ADV in vivo.

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Section: Virological Findingssupporting

confidence: 87%

Violet Mink Develop an Acute Disease after Experimental Infection with Aleutian Disease Virus (ADV) Isolate ADV SL3

Haas

Wohlsein

Trautwein

et al. 1990

Journal of Veterinary Medicine, Series B

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“…Autonomous parvoviruses are the cause of a number of diseases in humans and animals (7,32). In contrast, attempts to implicate AAV as an etiological agent of disease have thus far failed (6).…”

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confidence: 99%

Influence of adeno-associated virus on adherence and growth properties of normal cells

Bantel-Schaal

Stöhr

1992

J Virol

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It has been shown previously that infection of newly established cell cultures from malignant human tumors with adeno-associated parvovirus type 2 or type 5 results in growth arrest and cell death. Here we report that the additionally observed antiproliferative effect on diploid human fibroblasts is transient and is connected to a reduced number of cells in S phase. Progression through the cell cycle is disturbed either in GO/G1 or at the G1/S boundary, but an additional arrest in G2 cannot be excluded. DNA synthesis and cell proliferation are resumed when cells are recultured after loosening of cell-matrix adhesions by trypsin treatment. In contrast, they are not resumed by solely providing growth factors via higher amounts of fetal calf serum. The results suggest that cell adherence is altered in adeno-associated parvovirus-infected human embryo fibroblasts.

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“…Although the putative NS3 had no similarity to any Genbank sequence, analysis of the amino acids sequence exhibits a conserved Zn-finger motif from NS3-like of several insect viruses (Krupovic and Koonin, 2014). ITRs are also essential for replication, encapsulation and genome integration (Siegl and Tratschin, 1987;Zádori et al, 2001). Due to the presence of palindromic repeats, the most common structure found in the Densovirinae subfamily are J-shaped telomeres, but they can also be found in T-, I-, Y-, U-or simple hairpin-like structures (Laugel et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Metagenomic analysis reveals novel dietary-related viruses in the gut virome of marmosets hybrids (Callithrix jacchus x Callithrix penicillata), Brazil

Miranda

Schiffler

D’arc

et al. 2022

Preprint

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Viral metagenomics has contributed enormously to the characterization of a wide range of viruses infecting animals of all phyla in the last decades. Among Neotropical primates, especially those free-living introduced, knowledge about viral diversity remains poorly studied. Therefore, through the use of metagenomics based on virus enrichment, we the aim of this study was to explored the viral microbiota present in the feces of introduced common marmosets (Callithrix sp.) in three locations from the Silva Jardim region in the State of Rio de Janeiro, Brazil. Fecal samples were collected from nine marmosets, pooled into three sample pools and sequenced on Illumina MiSeq platform. Sequence reads were analyzed using a viral metagenomic analysis pipeline and two novel insect viruses belonging to the Parvoviridae and Baculoviridae families were identified. The complete genome of a densovirus (Parvoviridae family) of 5,309 nucleotides (nt) was obtained. The NS1 and VP1 proteins share lower than 32% sequence identity with the corresponding proteins of known members of the subfamily Densovirinae. Phylogenetic analysis suggests that this virus represents a new genus, named Tritonambidensovirus due to telomeric structures at the 3' and 5' ends of the genome. The novel species received the name Fecalis tritonambidensovirus 1. The complete circular genome of a baculovirus of 107,191 nt was also obtained, showing 60.8% sequence identity with the most closely-related member of the Baculoviridae family. Phylogenetic analysis suggests that this virus represents a new species of Betabaculovirus, named Callithrix fecalis granulovirus. In addition, sequences from several families of arthropods in the three pools evaluated were characterized (contigs ranging from 244 to 6,750 nt), corroborating the presence of possible insect hosts with which these new viruses may be associated. Our study expands the knowledge about two viral families known to infect insects, an important component of the marmosets' diet. This identification in hosts' feces samples demonstrates one of the many uses of this type of data and could serve as a basis for future research characterizing viruses in wildlife using noninvasive samples.

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Parvoviruses: agents of distinct pathogenic and molecular potential

Cited by 16 publications

References 107 publications

Violet Mink Develop an Acute Disease after Experimental Infection with Aleutian Disease Virus (ADV) Isolate ADV SL3

Violet Mink Develop an Acute Disease after Experimental Infection with Aleutian Disease Virus (ADV) Isolate ADV SL3

Influence of adeno-associated virus on adherence and growth properties of normal cells

Metagenomic analysis reveals novel dietary-related viruses in the gut virome of marmosets hybrids (Callithrix jacchus x Callithrix penicillata), Brazil

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