Parylene C Aging Studies.

Abstract

Parylene C is used in a device because of its conformable deposition and other advantages. Techniques to study Parylene C aging were developed, and "lessons learned" that could be utilized for future studies are the result of this initial study. Differential Scanning Calorimetry yielded temperature ranges for Parylene C aging as well as post-deposition treatment. Post-deposition techniques are suggested to improve Parylene C performance. Sample preparation was critical to aging regimen. Short-term (~40 days) aging experiments with free standing and ceramic-supported Parylene C films highlighted "lessons learned" which stressed further investigations in order to refine sample preparation (film thickness, single sided uniform coating, machine versus laser cutting, annealing time, temperature) and testing issues ("necking") for robust accelerated aging of Parylene C.

Impact of Non-Accelerated Aging on the Properties of Parylene C

“…Existing studies are performed in the context of medical applications and the barrier properties of Parylene and based on accelerated aging [ 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 ]. Doing so, the aging of Parylene is accelerated by elevated temperatures to determine any impact on chemical or physical properties [ 35 ].…”

Crystallization and preliminary X-ray crystallographic studies of transglutaminase 2 in complex with Ca2+

“…Two representative functions of TG2 are protein cross-linking and GTP hydrolysis activities (Lee et al, 1989;Griffin et al, 2002). Protein cross-linking activity by transamidation is positively controlled by calcium and negatively regulated by GTP (Achyuthan & Greenberg, 1987). Human TG2 consists of an N-terminal -sandwich domain, a catalytic domain and two C-terminal -barrel domains (Liu et al, 2002).…”