Passage of Gliadin into Human Breast Milk

Troncone, Riccardo; Scarcella, A; A, Donatiello; Cannataro, P; Tarabuso, A; Auricchio, Salvatore

doi:10.1111/j.1651-2227.1987.tb10498.x

Cited by 100 publications

(48 citation statements)

References 10 publications

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“…These dietary proteins can be demonstrated in mothers' milk (Kilshaw and Cant, 1984;Troncone et al, 1987). Feeding babies also ingest human casomorphins in the mothers' normal milk.…”

Section: Early and Late Onset Subtypesmentioning

confidence: 96%

Can the Pathophysiology of Autism be Explained by the Nature of the Discovered Urine Peptides?

Reichelt¹,

Knivsberg

2003

Nutritional Neuroscience

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Opioid peptides derived from food proteins (exorphins) have been found in urine of autistic patients. Based on the work of several groups, we try to show that exorphins and serotonin uptake stimulating factors may explain many of the signs and symptoms seen in autistic disorders. The individual symptoms ought to be explainable by the properties and behavioural effects of the found peptides. The data presented form the basis of an autism model, where we suggest that exorphins and serotonin uptake modulators are key mediators for the development of autism. This may be due to a genetically based peptidase deficiency in at least two or more peptidases and, or of peptidase regulating proteins made manifest by a dietary overload of exorphin precursors such as by increased gut uptake.

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“…These dietary proteins can be demonstrated in mothers' milk (Kilshaw and Cant, 1984;Troncone et al, 1987). Feeding babies also ingest human casomorphins in the mothers' normal milk.…”

Section: Early and Late Onset Subtypesmentioning

confidence: 96%

Can the Pathophysiology of Autism be Explained by the Nature of the Discovered Urine Peptides?

Reichelt¹,

Knivsberg

2003

Nutritional Neuroscience

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“…b-Lactoglobulin, casein, and bovine gglobulin have been detected in nanogram concentrations in the breast milk of women not specifically avoiding cow's milk products during lactation. 27 Egg 28 and wheat 29 allergens have been detected in breast milk as little as 2 to 6 hours after maternal ingestion and can be detected as long as 4 days later. Peanut proteins have been measured in breast milk by both ELISA and immunoblot analysis.…”

Section: Allergens In Breast Milkmentioning

confidence: 98%

The role of breast-feeding in the development of allergies and asthma

Friedman

Zeiger

2005

Journal of Allergy and Clinical Immunology

321

198

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“…In human breast milk the presence of β-lactoglobulin from cow's milk, ovalbumin and ovomucoid from eggs, and gliadin from wheat has been demonstrated in previous studies [1,2,3,4,5]. In terms of peanut allergy, recent data from the German Registry of Anaphylaxis revealed that peanut allergy is no longer a life-threatening problem of the USA only, but is of growing significance in German-speaking countries as well [6].…”

Section: Introductionmentioning

confidence: 99%

Detection of the Peanut Allergens Ara h 2 and Ara h 6 in Human Breast Milk: Development of 2 Sensitive and Specific Sandwich ELISA Assays

Schocker

Scharf

Kull

et al. 2017

Int Arch Allergy Immunol

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Background: Little is known about breast milk as a vehicle for tolerance development or sensitization to peanuts very early in life. Thus, well-characterized and highly sensitive detection systems for the reliable determination of peanut allergens in breast milk are mandatory. Methods: For the quantification of the marker allergens Ara h 2 and Ara h 6 in the low nanogram per milliliter range in breast milk samples of a German cohort, sensitive and highly specific sandwich ELISAs were optimized and validated. Results: The Ara h 2 ELISA revealed a limit of detection (LOD) of 1.3 ng Ara h 2/mL and a quantification range of 2.3-250 ng/mL, the Ara h 6 ELISA showed an LOD of 0.7 ng/mL and a working range of 1.1-14.4 ng/mL. The assays showed no relevant cross-reactivity against other potentially cross-reactive legume, seed, and tree nut extracts (<0.01%, except for Ara h 1 in the Ara h 2 ELISA <0.1%). Ara h 2 was detectable in breast milk samples from 14/40 (35%) of the participants in concentrations from 2.3 to 184 ng/mL, Ara h 6 appeared in 9/40 (22.5%) of the lactating mothers between 1.1 and 9.7 ng/mL, and 1 highly positive sample with 79 ng/mL. Both allergens appeared at the same time points, but Ara h 6 in lower concentrations than Ara h 2. Conclusions: Sensitive and specific diagnostic tools for the determination of Ara h 2 and Ara h 6 in human breast milk were established. The kinetics of secreted Ara h 2 and Ara h 6 seem to be similar but with a difference in concentration. Follow-up investigations on their tolerogenic or sensitizing properties in breast milk become now accessible.

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Passage of Gliadin into Human Breast Milk

Cited by 100 publications

References 10 publications

Can the Pathophysiology of Autism be Explained by the Nature of the Discovered Urine Peptides?

Can the Pathophysiology of Autism be Explained by the Nature of the Discovered Urine Peptides?

The role of breast-feeding in the development of allergies and asthma

Detection of the Peanut Allergens Ara h 2 and Ara h 6 in Human Breast Milk: Development of 2 Sensitive and Specific Sandwich ELISA Assays

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