Passage of uranium through human cerebral microvascular endothelial cells: influence of time exposure in mono- and co-culture in vitro models

Gloaguen, C.; Raimundo, Ana; Elie, Christelle; Schmitt, Alain; Floriani, Magali; Favard, Séverine; Monneret, Denis; Imbert‐Bismut, Françoise; Weiss, Nicolas; Deli, Mária A.; Tack, Karine; Lestaevel, Philippe; Benadjaoud, Mohamedamine; Legendre, Audrey

doi:10.1080/09553002.2020.1828655

Cited by 3 publications

(1 citation statement)

References 39 publications

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“…It is also accompanied by heavy metal pollution, such as Cd, Cu, Pb, Mn and Zn, which are often reflected in the soil, sediment and water medium [ 4 , 5 , 6 , 7 , 8 ]. Heavy metal pollution around uranium mines has become a hot spot of concern because heavy metals are difficult to degrade, accumulate and easily migrate to the human body through skin, breath and diet [ 9 , 10 , 11 ]. At present, the evaluation of mine pollution is usually physical and chemical monitoring and evaluation, mainly using the Nemerow index [ 12 , 13 ], geoaccumulation index [ 14 , 15 , 16 ], potential risk index [ 17 , 18 , 19 , 20 ], etc.…”

Section: Introductionmentioning

confidence: 99%

Study on the Ecotoxic Effects of Uranium and Heavy Metal Elements in Soils of a Uranium Mining Area in Northern Guangdong

Zhang

Tang

Liu³

et al. 2023

Toxics

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To investigate the heavy metal contamination of soil in a uranium mining area in northern Guangdong, a physicochemical evaluation method was used to evaluate the contaminated soil near the pit and tailings pond of the uranium mining area, determine its heavy metal content and evaluate its ecological risk using the Nemerow integrated contamination index, ground accumulation index and potential ecological risk index. The results show that the average content of nine heavy metal elements in the soil of the uranium mining area exceeds the background value of red soil in Guangdong Province. Three pollution evaluation indices all indicate that Cd, As and U have serious pollution and high ecological risk, while the remaining elements are weakly polluted and the potential ecological risk of the six sampling sites all show very strong risk. On this basis, soil ecotoxicity was evaluated using ostracods (Cypridopsis vidua and Heterocypris sp.), Vibrio fischeri and Vicia faba L. Higher concentrations of heavy metals at individual sites (T1, T2, P2) resulted in higher mortality of ostracods, higher inhibition of Vibrio fischeri luminescence and a significant reduction in germination and pigmentation of broad beans. The results of the biotoxicity evaluation were consistent with the results of the physicochemical evaluation, allowing for a more direct and comprehensive evaluation of the ecotoxic effects of uranium and heavy metals in the mine soils.

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Section: Introductionmentioning

confidence: 99%

Study on the Ecotoxic Effects of Uranium and Heavy Metal Elements in Soils of a Uranium Mining Area in Northern Guangdong

Zhang

Tang

Liu³

et al. 2023

Toxics

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Induction of lysosomal exocytosis and biogenesis via TRPML1 activation for the treatment of uranium-induced nephrotoxicity

et al. 2023

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Uranium (U) is a well-known nephrotoxicant which forms precipitates in the lysosomes of renal proximal tubular epithelial cells (PTECs) after U-exposure at a cytotoxic dose. However, the roles of lysosomes in U decorporation and detoxification remain to be elucidated. Mucolipin transient receptor potential channel 1 (TRPML1) is a major lysosomal Ca2+ channel regulating lysosomal exocytosis. We herein demonstrate that the delayed administration of the specific TRPML1 agonist ML-SA1 significantly decreases U accumulation in the kidney, mitigates renal proximal tubular injury, increases apical exocytosis of lysosomes and reduces lysosomal membrane permeabilization (LMP) in renal PTECs of male mice with single-dose U poisoning or multiple-dose U exposure. Mechanistic studies reveal that ML-SA1 stimulates intracellular U removal and reduces U-induced LMP and cell death through activating the positive TRPML1-TFEB feedback loop and consequent lysosomal exocytosis and biogenesis in U-loaded PTECs in vitro. Together, our studies demonstrate that TRPML1 activation is an attractive therapeutic strategy for the treatment of U-induced nephrotoxicity.

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Single and combined effects of Ni and Cr on the freshwater ostracod Cypridopsis vidua

Su,

Tao,

Liu

et al. 2024

Environmental Pollutants and Bioavailability

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Passage of uranium through human cerebral microvascular endothelial cells: influence of time exposure in mono- and co-culture in vitro models

Cited by 3 publications

References 39 publications

Study on the Ecotoxic Effects of Uranium and Heavy Metal Elements in Soils of a Uranium Mining Area in Northern Guangdong

Study on the Ecotoxic Effects of Uranium and Heavy Metal Elements in Soils of a Uranium Mining Area in Northern Guangdong

Induction of lysosomal exocytosis and biogenesis via TRPML1 activation for the treatment of uranium-induced nephrotoxicity

Single and combined effects of Ni and Cr on the freshwater ostracod Cypridopsis vidua

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