These studies have neglected that innovation activities in a country are generated by interactions among different sectors, especially manufacturing. The existing literature focusing on the influence of manufacturing on innovation indicated that an integrated pipeline of information technology, materials, and production process in manufacturing operation will provide manufacturers with the capability to bring renewed dynamism to this sector (Jagoda, Kiridena, & Lin, 2016). Manufacturing plays a critical role in innovative production by providing precision instruments and integrated systems that can efficiently transform investments in innovation into products (Cozzarin, 2016). However, studies rarely investigate the influence of manufacturing on the innovation process for emerging economies.This study provides an alternative model by characterizing the process of innovation via a three-stage model that emphasizes manufacturing effects. This model consists of human capital cultivation (Stage 1), manufacturing development (Stage 2), and innovation production (Stage 3). The dynamic network slacks-based measure (SBM), which can deal with multiple input/output variables of multidivisions in a long-term optimization, is employed to evaluate the performance of this three-stage model. This study also utilizes a truncated regression method to explore external factors, including enrollment rate in higher education, market size, intellectual property protection, and knowledge transfer (KT) that affect innovation efficiency. The empirical results may shed light on the importance of manufacturing to emerging economies in terms of improvement in the production of innovations. The structure of this study is presented as follows. Section 2 provides the literature review. Section 3 introduces the innovation model, data collection procedure, and research methodology. Section 4 addresses the experimental results. Section 5 provides managerial implications for innovation in emerging economies. Section 6 offers conclusions of this study.