Passing through the renal clearance barrier: toward ultrasmall sizes with stable ligands for potential clinical applications

Zhang, Xiao Dong; Yang, Jiang; Song, Shasha; Long, Wei; Chen, Jie; Shen, Xiu; Wang, Hao; Sun, Yang; Liu, Peixun; Fan, Saijun

doi:10.2147/ijn.s64301

Cited by 33 publications

(18 citation statements)

References 55 publications

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“…Target-oriented differences in biodistribution -due to differences in the charges -could be observed, which indicated that positive Au NCs preferred to accumulate in the kidneys. [47][48][49] Additionally, higher retention in other RES organs such as liver and spleen at 1 day after administration indicate fast clearance from the bloodstream.…”

Section: Biodistribution and Excretionmentioning

confidence: 99%

Effects of surface charges of gold nanoclusters on long-term in vivo biodistribution, toxicity, and cancer radiation therapy

Wang

Chen

Yang

et al. 2016

IJN

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Gold nanoclusters (Au NCs) have exhibited great advantages in medical diagnostics and therapies due to their efficient renal clearance and high tumor uptake. The in vivo effects of the surface chemistry of Au NCs are important for the development of both nanobiological interfaces and potential clinical contrast reagents, but these properties are yet to be fully investigated. In this study, we prepared glutathione-protected Au NCs of a similar hydrodynamic size but with three different surface charges: positive, negative, and neutral. Their in vivo biodistribution, excretion, and toxicity were investigated over a 90-day period, and tumor uptake and potential application to radiation therapy were also evaluated. The results showed that the surface charge greatly influenced pharmacokinetics, particularly renal excretion and accumulation in kidney, liver, spleen, and testis. Negatively charged Au NCs displayed lower excretion and increased tumor uptake, indicating a potential for NC-based therapeutics, whereas positively charged clusters caused transient side effects on the peripheral blood system.

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Section: Biodistribution and Excretionmentioning

confidence: 99%

Effects of surface charges of gold nanoclusters on long-term in vivo biodistribution, toxicity, and cancer radiation therapy

Wang

Chen

Yang

et al. 2016

IJN

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“…Ideal nanomaterial should be effectively cleared out of the body, have little accumulation in organs. Sub-5.5 nm particles can pass through the barrier for renal clearance [50]. However, we need to know whether these particles still could pass through glomerulus when they are functioned by connecting with other molecules such as antibodies.…”

Section: Western Blotting and Immunohistochemistymentioning

confidence: 99%

The Excretion of BRCAA Antibody-Conjugated Gold Nanoclusters from Kidneys of Treated Rats

Liu¹,

Li²,

Wu³

et al. 2017

Nano BioMed ENG

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The gold nanoclusters (Au-NCs) have emerged for delivery of various payloads such as small molecular drug and big molecular proteins due to their low immunogenicity, quick clearance and good biocompatibility. Even though they have shown great prospective in biomedical area, there are also some security problems which should be investigated further more. BRCAA1 mAb Au-NCs is a probe for gastric cancer diagnosis prepared by conjugating BRCAA1 monoclonal antibody with fluorescent Au-NCs. In this research, the renal excretion and effect on glomerulus filtration of BRCAA1 mAb AuNCs in rats were investigated. The result indicated that BRCAA1 mAb Au-NCs could be eliminated through the glomerulus filtration as early as 2 hr after the administration following the excretion of other proteins in the plasma such as immunoglobulin. Electron microscope image and pathological analysis of kidney showed that BRCAA1 mAb Au-NCs induced some structural injury such as capillaries endotheliocyte damage, pycnosis, karyorrhexis and hyalomitome acidophilia enhancement. Biochemical indexes including ALT, AST, BUN, TBIL, CK and CREA are abnormal in the period of 2 to 48 hr after the administration. The results of Western blotting and immunohistochemisty show the downregulation of three key proteins (ZO-1, Nephrin and Podocin) indicating the influence of BRCAA1 mAb Au-NCs on the foot processes of glomerular epithelial cells and shallow intercellular junctions or slit diaphragms.

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“…Recent progresses in silicon carbide (SiC) crystal, film's synthesis [1][2][3][4][5][6][7][8][9][10], and investigations of nano-polytype properties are highly important for applications in harsh environments [11], in optoelectronics [12,13] and spintronics [14,15], in quantum information processing [16][17][18], in biotechnology [19,20] and medicine [21,22]. Silicon carbide [23] can be a suitable prototype material for investigations of the polytypism phenomena in wide band semiconductors and binary materials.…”

Section: Introductionmentioning

confidence: 99%

Introducing a new atomic parameter of energy scale for wideband semiconductors and binary materials

2019

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The fundamental concept in the science of dislocations is the study of the optical properties of semiconductors. The purpose of this work is to investigate the dependence of the structural features of the low-temperature photo luminescence (LTPL) spectra with the lattice parameters of wideband semiconductors and binary materials. A decoding method of the LTPL spectra of the binary polytypic structures of SiC was used. As a result, we introduce here for the first time a new i-unit atomic parameter of energy scale for the LTPL spectra of binary polytypic nanostructures. The i-unit parameter equals 4.3 meV, i.e. which equals 1/2 of the distance between adjacent Si-C layers and gives the exact multiples of the basic spectral parameters to tenths of meV. The i-unit of energy scale allows the simplifying method of spectral analysis of fine structures in SiC polytypes. The proposed new atomic i-scale allows us to monitor the processes of phase transformations up to 0.0787 Å. This allows observing the displacement in tetrahedron of silicon and carbon with dimensions 7.56 Å. The introduction of a new energy parameter makes it possible to control the displacement and position of atoms with very high accuracy, which in turn is very important for understanding the nature of defects in semiconductors. It is shown that phase transformations in SiC are related to dislocation in the crystal and implemented by the deformation and diffusion mechanisms. Due to results the diagram of the interlayer scheme radiative recombination with resulting dislocation levels was introduced.

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Passing through the renal clearance barrier: toward ultrasmall sizes with stable ligands for potential clinical applications

Cited by 33 publications

References 55 publications

Effects of surface charges of gold nanoclusters on long-term in vivo biodistribution, toxicity, and cancer radiation therapy

Effects of surface charges of gold nanoclusters on long-term in vivo biodistribution, toxicity, and cancer radiation therapy

The Excretion of BRCAA Antibody-Conjugated Gold Nanoclusters from Kidneys of Treated Rats

Introducing a new atomic parameter of energy scale for wideband semiconductors and binary materials

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