Passive catheter tracking during interventional MRI using hyperpolarized <sup>13</sup>C

Magnusson, Peter; Johansson, Edvin; Månsson, Sven; Petersson, Johan; Chai, Chun-Ming; Hansson, Georg; Axelsson, Oskar; Golman, Klaes

doi:10.1002/mrm.21239

Cited by 44 publications

(35 citation statements)

References 26 publications

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“…The potential applications of hyperpolarized 13 C imaging include vascular imaging, perfusion imaging (158), catheter tracking (159), and visualization and metabolic/molecular imaging (152). The PHIP method increases the nuclear polarization by a chemical reaction of parahydrogen with a substrate containing double or triple bonds (160).…”

Section: Hyperpolarized Agents and Molecular Imaging Using Mrimentioning

confidence: 99%

Classification and basic properties of contrast agents for magnetic resonance imaging

Geraldes

Laurent

2009

Contrast Media & Molecular

491

409

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A comprehensive classification of contrast agents currently used or under development for magnetic resonance imaging (MRI) is presented. Agents based on small chelates, macromolecular systems, iron oxides and other nanosystems, as well as responsive, chemical exchange saturation transfer (CEST) and hyperpolarization agents are covered in order to discuss the various possibilities of using MRI as a molecular imaging technique. The classification includes composition, magnetic properties, biodistribution and imaging applications. Chemical compositions of various classes of MRI contrast agents are tabulated, and their magnetic status including diamagnetic, paramagnetic and superparamagnetic are outlined. Classification according to biodistribution covers all types of MRI contrast agents including, among others, extracellular, blood pool, polymeric, particulate, responsive, oral, and organ specific (hepatobiliary, RES, lymph nodes, bone marrow and brain). Various targeting strategies of molecular, macromolecular and particulate carriers are also illustrated.

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Section: Hyperpolarized Agents and Molecular Imaging Using Mrimentioning

confidence: 99%

Classification and basic properties of contrast agents for magnetic resonance imaging

Geraldes

Laurent

2009

Contrast Media & Molecular

491

409

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“…19 The first water-soluble reagent capable of PHIP was hydroxymethyl acrylate, which on (para)-hydrogenation becomes 13 C hydroxyethylpropionate (HEP), developed by Amersham (Malmo, Sweden) and used in surviving animals to provide ultrafast 13 C angiography in pigs. 20 HEP is toxic, as is the novel catalyst, but 2 successor molecules developed at Huntington Medical Research Institutes, Pasadena, California, 1-13 C malic acid 10 ( Fig 6, left) and 1-13 C fumaric acid 14 (Fig 6, right), both provided a practical synthetic route to the biologic intermediate of the Krebs-TCA cycle, 1-13 C succinate. Also illustrated in Fig 6 are the chemical process, the molecular addition of parahydrogen under the influence of a specific catalyst and the spin physics of polarization transfer, 21 which were developed in Malmo, Sweden, to dramatically elevate the yield and bring hyperpolarization to Ն40% within a few seconds in the specially designed polarizer.…”

Section: Hd-mr Imaging In Practicementioning

confidence: 99%

Hyperpolarized MR Imaging: Neurologic Applications of Hyperpolarized Metabolism

Ross

Bhattacharya²,

Wagner³

et al. 2009

AJNR Am J Neuroradiol

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SUMMARY:Hyperpolarization is the general term for a method of enhancing the spin-polarization difference of populations of nuclei in a magnetic field. No less than 5 distinct techniques (dynamic nuclear polarization [DNP]; parahydrogen-induced polarizationϪparahydrogen and synthesis allow dramatically enhanced nuclear alignment [PHIP-PASADENA]; xenon/helium polarization transfer; Brute Force; 1 H hyperpolarized water) are currently under exhaustive investigation as means of amplifying the intrinsically (a few parts per million) weak signal intensity used in conventional MR neuroimaging and spectroscopy. HD-MR imaging in vivo is a metabolic imaging tool causing much of the interest in HD-MR imaging. The most successful to date has been DNP, in which carbon-13 ( 13 C) pyruvic acid has shown many. PHIP-PASADENA with 13 C succinate has shown HD-MR metabolism in vivo in tumorbearing mice of several types, entering the KrebsϪtricarboxylic acid cycle for ultrafast detection with 13 C MR imaging, MR spectroscopy, and chemical shift imaging. We will discuss 5 promising preclinical studies:13 C succinate PHIP in brain tumor; 13 C ethylpyruvate DNP and 13 C acetate; DNP in rodent brain;13 C succinate PHIP versus gadolinium imaging of stroke; and 1 H hyperpolarized imaging. Recent developments in clinical 13 C neurospectroscopy encourage us to overcome the remaining barriers to clinical HD-MR imaging.T he symposium 1 dealt with the topic of novel contrast agents "that enhance your image." If the definition of contrast is the addition of any new dimension, then a reasonable theme for this review-which asks whether hyperpolarized (HD)-MR imaging and spectroscopy of the brain are both feasible and contributory-would be to discuss the novel contrast that is enhanced by chemistry. Chemical ContrastMore than 80 brain metabolites can be distinguished and displayed (as a spectrum) by using MR spectroscopy. However, a quick glance at the metabolic diagram provided as a guide to the human single-voxel proton brain examination (the conventional and automated PROBE/SV; GE Healthcare, Milwaukee, Wisconsin) shows that we do not directly observe any metabolites of the KrebsϪtricarboxylic acid (TCA-the centerpiece of cerebral mitochondrial energy metabolism) cycle and do not draw any conclusions about it or several other important aspects of brain chemistry, except by inference. Under special circumstances, the TCA cycle intermediates do appear in a human brain spectrum. As an example, succinate, at an estimated concentration of 25 mmol/L, appears at a chemical shift of 2.42 ppm. The concentration has been estimated on the basis of the reference creatine (Cr) peak at 3.02 ppm, which is generally present at a 10-mmol/L concentration (an "amount" of succinate, for the 8-cm 3 result, equivalent to 200 mol). For future reference, for the proton spectrum, 4 minutes' accumulation detected 200 mol of succinate, approximately 50 mol/min. Spatial ContrastChemical shift imaging, so-called because multiple spectra are acquired during a single MR spec...

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“…The hyperpolarization technique using 13 C, incorporated into small molecules (19,20), has produced polarization levels several orders of magnitude higher than thermal equilibrium values. The use of hyperpolarized 13 C substances for MR angiography (21,22), passive catheter tracking in interventional MRI (23), and perfusion (24,25) has been demonstrated. The dynamic nuclear polarization (DNP) method (20) may be used to enhance the signal of the 13 C-nuclei in endogenous substances such as amino acids, urea, and pyruvate (26,27), making it possible to perform in vivo visualization of the injected substances and their metabolites.…”

mentioning

confidence: 99%

Cardiac metabolism measured noninvasively by hyperpolarized ¹³C MRI

Golman

Petersson

Magnusson

et al. 2008

Magnetic Resonance in Med

Self Cite

207

238

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Pyruvate is included in the energy production of the heart muscle and is metabolized into lactate, alanine, and CO 2 in equilibrium with HCO 3 ؊ . The aim of this study was to evaluate the feasibility of using 13 C hyperpolarization enhanced MRI to monitor pyruvate metabolism in the heart during an ischemic episode. The left circumflex artery of pigs (4 months, male, 29 -34 kg) was occluded for 15 or 45 min followed by 2 hr of reperfusion. Pigs were examined by 13 C chemical shift imaging following intravenous injection of 1-13 C pyruvate. 13 C chemical shift MR imaging was used in order to visualize the local concentrations of the metabolites. After a 15-min occlusion (no infarct) the bicarbonate signal level in the affected area was reduced (25-44%) compared with the normal myocardium. Alanine signal level was normal. After a 45-min occlusion (infarction) the bicarbonate signal was almost absent (0.2-11%) and the alanine signal was reduced (27-51%). Due to image-folding artifacts the data obtained for lactate were inconclusive. These studies demonstrate that cardiac metabolic imaging with hyperpolarized 1-13 C-pyruvate is feasible. The changes in concentrations of the metabolites within a minute after injection can be detected and metabolic maps constructed. Magn Reson Med 59:1005-1013, 2008.

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Passive catheter tracking during interventional MRI using hyperpolarized ¹³C

Cited by 44 publications

References 26 publications

Classification and basic properties of contrast agents for magnetic resonance imaging

Classification and basic properties of contrast agents for magnetic resonance imaging

Hyperpolarized MR Imaging: Neurologic Applications of Hyperpolarized Metabolism

Cardiac metabolism measured noninvasively by hyperpolarized ¹³C MRI

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Passive catheter tracking during interventional MRI using hyperpolarized 13C

Cited by 44 publications

References 26 publications

Classification and basic properties of contrast agents for magnetic resonance imaging

Classification and basic properties of contrast agents for magnetic resonance imaging

Hyperpolarized MR Imaging: Neurologic Applications of Hyperpolarized Metabolism

Cardiac metabolism measured noninvasively by hyperpolarized 13C MRI

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Product

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Passive catheter tracking during interventional MRI using hyperpolarized ¹³C

Cardiac metabolism measured noninvasively by hyperpolarized ¹³C MRI