Passive Cutaneous Anaphylaxis-Inhibitory Action of Tectorigenin, a Metabolite of Tectoridin by Intestinal Microflora

Park, Eunkyung; Shin, Yong-Wook; Lee, Hae-Ung; Lee, Chang‐Soo; Kim, Dong-Hyun

doi:10.1248/bpb.27.1099

Cited by 35 publications

(7 citation statements)

References 18 publications

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“…The metabolic fates of TD and TG are associated with the hydrolysis of 7‐ O ‐glucosyl, O ‐methylation, sulfation, disulfation and glucuronidation of hydroxyl groups and mono‐ and dihydroxylations . Comparative studies have shown that TG has more potent biological activity than TD .…”

Section: Introductionmentioning

confidence: 99%

Fluorescence spectroscopy and docking study in two flavonoids, isolated tectoridin and its aglycone tectorigenin, interacting with human serum albumin: a comparison study

Wang

et al. 2015

Luminescence

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Two flavonoids, tectoridin (TD) isolated from rhizomes of Iris tectorum and hydrolyzed aglycone tectorigenin (TG) were prepared and characterized to compare their different interaction ability with human serum albumin (HSA). Based on the results, the affinity of TG-HSA was stronger than that of TD-HAS, and TG combined more closely with HSA than did TD. HSA fluorescence was quenched by TD/TG. The interactions between TD/TG and HSA involved static quenching. The thermodynamic parameters indicated that both binding processes were spontaneous; hydrogen binding and van der Waals force were the main forces between TD and HSA, whereas a hydrophobic interaction was the main binding force between TG and HSA. Synchronous and 3D fluorescence spectra showed that the binding of TD/TG to HSA induced conformational changes. Moreover, a docking study confirmed the experimental results.

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Section: Introductionmentioning

confidence: 99%

Fluorescence spectroscopy and docking study in two flavonoids, isolated tectoridin and its aglycone tectorigenin, interacting with human serum albumin: a comparison study

Wang

et al. 2015

Luminescence

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“…The chemical components of herbs can be transformed by intestinal bacteria before being absorbed from the gastrointestinal tract. Park et al (16) reported that when tectoridin was administered to rats, tectorigenin, but not tectoridin, was detected in the urine. However, tectoridin did not hydrolyze the tectorigenin from a rat liver homogenate.…”

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confidence: 99%

Hepatoprotective Effect of Tectoridin and Tectorigenin on tert-Butyl Hyperoxide-Induced Liver Injury

2005

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Abstract. To clarify the hepatoprotective effects of tectoridin and tectorigenin from Puerariae Flos, their effects on tert-butyl hyperoxide (t-BHP)-injured HepG2 cells and mice were investigated. When tectorigenin at a dose of 50 mg / kg was intraperitoneally administered to mice injured by t-BHP, it significantly inhibited the increase the activities of plasma ALT and AST by 39% and 41%, respectively, in the t-BHP-treated group. The inhibitory effect of tectorigenin is much more potent than that of a commercially available dimethyl diphenyl bicarboxylate. Orally administered tectoridin showed hepatoprotective activity. However, when tectoridin was intraperitoneally administrated to mice, no hepatoprotective activity was observed. Tectorigenin also protected against the cytotoxicity of HepG2 cells induced by t-BHP. This protection may have originated from the inhibition of apoptosis. Tectorigenin may be hepatoprotective and tectoridin should be a prodrug that is transformed to tectorigenin.Keywords: tectorigenin, HepG2, hepatic injury t-Butyl hydroperoxide (t-BHP) can be metabolized to free radical intermediates by cytochrome P450 (hepatocytes) or hemoglobin (erythrocytes), which can subsequently initiate lipid peroxidation (1), affect cell integrity, and form covalent bonds with cellular molecules, resulting in cell injury (2). t-BHP is known to cause lactate dehydrogenase and alanine transferase (ALT) leakage in hepatocyte cells (3, 4). Therefore, t-BHP has been used as a chemical inducer for the preparation of a liver injured animal model (5, 6).In traditional Chinese medicine, Puerariae Flos has been used in therapy to counteract the problems associated with alcohol drinking and liver injury (7). Niiho et al. (8,9) reported that the isoflavonoid fraction of Puerariae Flos suppressed the increase in the concentration of blood ethanol, acetaldehyde, and ketones induced by ethanol administration and that its isoflavonoid and triterpenoid saponin fractions improved both the abnormal metabolism induced by ethanol and hepatic injuries induced by carbon tetrachloride or highfat food. Jang et al. (10) reported that Puerariae Flos protected against ethanol-induced apoptosis in the human neuroblastoma cell line SK-N-MC. Lee et al. (11) reported that tectorigenin isolated from Puerariae Flos as an inhibitor of b-glucuronidase showed hepatoprotective activity on the CCl 4 -induced hepatotoxicity in mice.To clarify the hepatoprotective effects of isoflavones tectorigenin and tectoridin (Fig. 1) from Puerariae Flos, tectoridin was isolated from Puerariae Flos and its metabolite tectorigenin from human fecal microflora, and then we investigated their effects in t-BHP-injured HepG2 cells and mice.*Corresponding author. FAX: +82-2-957-5030 E-mail: dhkim@khu.ac.kr

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“…Allergic diseases such as asthma and atopic dermatitis are based on IgE-mediated pharmacologic processes of a variety of cell populations such as mast cell and basophils (Park et al, 2004). Orally administered tectoridin can be transformed, by intestinal bacteria, into the more active agent tectorigenin which potently inhibited the passive cutaneous anaphylaxis reaction.…”

Section: Other Biological Effectsmentioning

confidence: 99%

Phytochemicals and biological activities of Pueraria flower: a review

Wang¹,

Yang²,

Tao³

et al. 2021

Journal of Food Bioactives

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Pueraria lobata (Kudzu root) has been well documented as a food and also an herbal plant for its ability to alleviate hangover, diarrhea and cardiovascular diseases. However, the flower of Pueraria lobata has been attracted attention only in recent decades. Bioactive phytochemicals such as isoflavones, saponins, essential oils and other components have been isolated and identified in Pueraria flower extracts (PFE). Both in vivo and in vitro research have indicated the health promoting effects of Pueraria flower including hepatoprotective property, estrogenic effects, antioxidant activity, anti-inﬂammation activity and other pharmacological activities. In this review, we have summarized the chemical compositions and pharmacological actions of Pueraria flower and updated knowledge with recent progress.

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Passive Cutaneous Anaphylaxis-Inhibitory Action of Tectorigenin, a Metabolite of Tectoridin by Intestinal Microflora

Cited by 35 publications

References 18 publications

Fluorescence spectroscopy and docking study in two flavonoids, isolated tectoridin and its aglycone tectorigenin, interacting with human serum albumin: a comparison study

Fluorescence spectroscopy and docking study in two flavonoids, isolated tectoridin and its aglycone tectorigenin, interacting with human serum albumin: a comparison study

Hepatoprotective Effect of Tectoridin and Tectorigenin on tert-Butyl Hyperoxide-Induced Liver Injury

Phytochemicals and biological activities of Pueraria flower: a review

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