Passive immunotherapies for the next influenza pandemic

Focosi, Daniele; Franchini, Massimo; Senefeld, Jonathon W.; Joyner, Michael J.; Sullivan, David J.; Pekosz, Andrew; Maggi, Fabrizio; Casadevall, Arturo

doi:10.1002/rmv.2533

Reviews in Medical Virology

2024

DOI: 10.1002/rmv.2533

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Passive immunotherapies for the next influenza pandemic

Daniele Focosi,

Massimo Franchini,

Jonathon W. Senefeld

et al.

Abstract: Influenzavirus is among the most relevant candidates for a next pandemic. We review here the phylogeny of former influenza pandemics, and discuss candidate lineages. After briefly reviewing the other existing antiviral options, we discuss in detail the evidences supporting the efficacy of passive immunotherapies against influenzavirus, with a focus on convalescent plasma.

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Cited by 3 publications

References 221 publications

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(R)evolution of Viruses: Introduction to biothermodynamics of viruses

Popović,

Tadić,

Popović

2025

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(R)evolution of Viruses: Introduction to biothermodynamics of viruses

Popović,

Tadić,

Popović

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Stuck in a moment you can't get out of: the psychological effects of expatriates' coping with a crisis situation

Koveshnikov,

Lehtonen

2024

JGM

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PurposeWe draw upon stress theory and utilize the context of the COVID-19 pandemic to investigate how various coping strategies employed by expatriates affect their psychological stress, subsequently influencing their expatriation satisfaction and intention to withdraw from the host country.Design/methodology/approachWe utilize structural equation modeling to analyze a sample of 453 expatriates residing and working in the United Arab Emirates during the COVID-19 pandemic.FindingsOur analysis shows that the effects of different coping strategies on expatriates vary. Depending on the nature of the strategy, they can have either positive or negative effects. While coping via problem-focused and denial strategies decreases expatriates' stress, coping by distancing increases it. Social support-seeking is not found to be an effective stress-coping strategy. In terms of implications, the problem-focused strategy leads to the most positive outcomes, whereas distancing leads to the most negative outcomes.Originality/valueOur study provides significant theoretical and practical insights into expatriates' coping mechanisms within the context of natural crises.

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Avian Influenza Virus A(H5Nx) and Prepandemic Candidate Vaccines: State of the Art

Focosi,

Maggi

2024

IJMS

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Avian influenza virus has been long considered the main threat for a future pandemic. Among the possible avian influenza virus subtypes, A(H5N1) clade 2.3.4.4b is becoming enzootic in mammals, representing an alarming step towards a pandemic. In particular, genotype B3.13 has recently caused an outbreak in US dairy cattle. Since pandemic preparedness is largely based on the availability of prepandemic candidate vaccine viruses, in this review we will summarize the current status of the enzootics, and challenges for H5 vaccine manufacturing and delivery.

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Passive immunotherapies for the next influenza pandemic

Cited by 3 publications

References 221 publications

(R)evolution of Viruses: Introduction to biothermodynamics of viruses

(R)evolution of Viruses: Introduction to biothermodynamics of viruses

Stuck in a moment you can't get out of: the psychological effects of expatriates' coping with a crisis situation

Avian Influenza Virus A(H5Nx) and Prepandemic Candidate Vaccines: State of the Art

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