Passive opium smoking does not have beneficial effect on plasma lipids and cardiovascular indices in hypercholesterolemic rabbits with ischemic and non-ischemic hearts

Najafipour, Hamid; Joukar, Siyavash; Afshar, Reza Malekpour; Mirzaeipour, Fateme; Nasri, Hamid

doi:10.1016/j.jep.2009.11.011

Cited by 29 publications

(29 citation statements)

References 26 publications

(29 reference statements)

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“…In addition, in two previous studies we found that opium decreased isoproterenol-induced heart lesions but was unable to reduce serum levels of cardiac troponin I (24,25). Moreover, it was reported that morphine therapy in acute decompensated heart failure significantly increased serum cardiac troponin I levels (26).…”

Section: Discussionmentioning

confidence: 71%

Cardiovascular effect of nifedipine in morphine dependent rats: hemodynamic, histopathological, and biochemical evidence

2012

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AimTo investigate whether administration of nifedipine has considerable therapeutic effect in morphine-dependent rats.MethodsSixty animals were randomized into control, morphine, morphine plus nifedipine, and morphine plus dimethyl sulfoxide (DMSO, as nifedipine soluble) groups. Each group consisted of two subgroups, with and without heart injury. The groups were treated with incremental doses of morphine or morphine plus nifedipine daily for 7 days. Myocardial injury was induced by isoproterenol (50 mg/kg i.p.) on the day 7. On the day 8, the heart rate (HR), blood pressure (BP), rate-pressure product (RPP), and the plasma level of cardiac troponin I were measured and the hearts were histopathologically examined.ResultsIn morphine-dependent rats, nifedipine administration was associated with a significantly higher decrease in the plasma level of cardiac troponin I than the administration of morphine alone. This finding was also significant in dependent animals that received only DMSO. HR, BP, RPP, and histopathological indices did not show significant changes in the presence of nifedipine.ConclusionAdministration of nifedipine failed to show a significant therapeutic effect in morphine-dependent rats, especially in the group with myocardial injury.

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Section: Discussionmentioning

confidence: 71%

Cardiovascular effect of nifedipine in morphine dependent rats: hemodynamic, histopathological, and biochemical evidence

2012

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“…Although it has been established that opium does not decrease blood pressure, serum lipids and blood glucose, it is being extensively abused and it is because of this wrong traditional belief that its outcome, opiumdependence, is a major public health problem in some parts of the world especially in Asia and the Middle-East [118][119][120][121][122]. In an animal study, Najafipour and Joukar investigated the long-term and short-term effects of opium smoking in association with hypercholesterolemic diet on cardiac arrhythmias.…”

Section: Opiummentioning

confidence: 99%

Opioids and Cardiac Arrhythmia: A Literature Review

2018

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Objective: One of the most important side effects of opioids is their influence on the electrical activity of the heart. This review focusses on the effects of opioids on QT interval prolongation and their arrhythmogenic liability. Methods: By using various keywords, papers published up to 2018 in different databases were searched and identified. The search terms were opioids names, corrected QT interval, human-ether-a-go-go gene, torsades de pointes (TdP), cardiac arrhythmias, opioid dependence and other relevant terms. It emphasized the effects of each opioid agent alone on electrocardiogram (ECG) and some interactions. Results: Available data indicate that some opioids such as methadone are high-risk even at low doses, and have potential for prolongation of the QT interval and development of TdP, a dangerous ventricular tachycardia. A number of opioids such as tramadol and oxycodone are intermediate risk drugs and may develop long QT interval and TdP in high doses. Some other opioids such as morphine and buprenorphine are low-risk drugs and do not produce QT interval prolongation and TdP at least in routine doses. Opium-consumers are at higher risk of supra-ventricular arrhythmias, sinus bradycardia, cardiac block and atrial fibrillation. Conclusion: The cardiac arrhythmogenicity of various opioids is different. Methadone has a higher capability to induce long QT interval and dangerous arrhythmias in conventional doses than others. To reduce of arrhythmogenic risk, high doses of opioids must be used cautiously with periodic monitoring of ECG in high-risk consumers such as patients under opioid maintenance treatment.

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“…Four-micrometer-thick slices were made from tissue samples and then stained with hematoxylin-eosin. Congestion and hemorrhage, hyper eosinophilia bundle, leukocyte infiltration, and necrosis indices were assessed under four categories, including severe (+++), moderate (++), mild (+), and normal (0) [21]. One point was given to each +, and the total histological score would amount to maximum 12 points for each animal.…”

Section: Methodsmentioning

confidence: 99%

“…In order to measure left ventricle pressure, the cannula in the carotid artery was slowly pushed forward into the left ventricle to record ventricle pressure. The Power Lab system automatically calculated the maximum ventricle contraction velocity (+dp/dt max) and maximum ventricle relaxation velocity (-dp/dt max) from ventricle pressure [21]. …”

Section: Methodsmentioning

confidence: 99%

Traumatic Brain Injury Has Not Prominent Effects on Cardiopulmonary Indices of Rat after 24 Hours: Hemodynamic, Histopathology, and Biochemical Evidence

Najafipour

Khachaki

Khaksari

et al. 1996

Iranian Biomedical Journal (IBJ); ISSN 1028-852x

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Passive opium smoking does not have beneficial effect on plasma lipids and cardiovascular indices in hypercholesterolemic rabbits with ischemic and non-ischemic hearts

Cited by 29 publications

References 26 publications

Cardiovascular effect of nifedipine in morphine dependent rats: hemodynamic, histopathological, and biochemical evidence

Cardiovascular effect of nifedipine in morphine dependent rats: hemodynamic, histopathological, and biochemical evidence

Opioids and Cardiac Arrhythmia: A Literature Review

Traumatic Brain Injury Has Not Prominent Effects on Cardiopulmonary Indices of Rat after 24 Hours: Hemodynamic, Histopathology, and Biochemical Evidence

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