Atmospheric gravity waves (GWs) can strongly modulate middle atmospheric circulation and can be a significant factor for the coupling between the lower atmosphere and the middle atmosphere. GWs are difficult to resolve in global atmospheric models due to their small scale; thus, GW observations play an important role in middle atmospheric studies. The climatology of GW variance and momentum in the low-latitude mesosphere and lower thermosphere (MLT) region are revealed using multiple meteor radars, which are located at Kunming (25.6°N, 103.8°E), Sanya (18.4°N, 109.6°E), and Fuke (19.5°N, 109.1°E). The climatology and longitudinal variations in GW momentum fluxes and variance over the low-latitude region are reported. The GWs show strong seasonal variations and can greatly control the mesospheric horizontal winds via modulation of the quasi-geostrophic balance and momentum deposition. The different GW activities between Kunming and Sanya/Fuke are possibly consistent with the unique prevailing surface winds over Kunming and the convective system over the Tibetan Plateau according to the European Centre for Medium-Range Weather Forecasts (ECMWF), Reanalysis v5 (ERA5) data, and outgoing longwave radiation (OLR) data. These findings provide insight for better understanding the coupling between the troposphere and mesosphere.