Passive smoking and impaired lung function in cystic fibrosis.

Smyth, Alan; O'Hea, Una; Williams, Geraint T.; Smyth, Rosalind L; Heaf, D P

doi:10.1136/adc.71.4.353

Cited by 62 publications

(43 citation statements)

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“…Our results expand the findings of 2 previous CF studies examining the effects of secondhand smoke exposure and socioeconomic status. These studies found that neither socioeconomic status as measured by Hollingshead strata 5 nor parental occupation 8 affected the association between secondhand smoke exposure and clinical outcomes. Previous studies of socioeconomic status in patients with CF have linked worse lung function with lower income 36 and participation in Medicaid, 37,38 however none of these studies included secondhand smoke exposure as a factor in the analyses.…”

Section: Commentmentioning

confidence: 89%

“…3 However, documentation using this definition may be subject to recall bias and underreporting. Two studies have observed that urine and salivary cotinine levels accurately reflect CF households' reported smoking 8,9 ; however one study has demonstrated underreporting of smoking in CF households using urine cotinine levels. 41 Regardless of potential recall bias or underreporting, the population of our family-based study reports a lower prevalence of secondhand smoke exposure (23% in the home) than has been seen in the general CF population (30%).…”

Section: Commentmentioning

confidence: 99%

“…For example, socioeconomic status has been correlated with cigarette smoking yet only 2 studies investigated its effect on the relationship between secondhand smoke exposure and clinical outcomes in patients with CF. 5,8 In addition, some studies have demonstrated that exposure to secondhand smoke is associated with poorer nutritional status in patients with CF by at least 1 measure, 5,7 whereas others have not. 4,8 Finally, 3 studies have explored the effects of secondhand smoke exposure in patients with known CFTR genotypes; in 2 studies only participants carrying 2 copies of the most common CF mutation (ΔF508) were analyzed, 4,5 and in the remaining study too few patients were enrolled to examine secondhand smoke interaction with the CFTR genotype.…”

mentioning

confidence: 99%

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Interactions Between Secondhand Smoke and Genes That Affect Cystic Fibrosis Lung Disease

Collaco¹,

Vanscoy²,

Bremer³

et al. 2008

JAMA

133

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Context Disease variation can be substantial even in conditions with a single gene etiology such as cystic fibrosis (CF). Simultaneously studying the effects of genes and environment may provide insight into the causes of variation.Objective To determine whether secondhand smoke exposure is associated with lung function and other outcomes in individuals with CF, whether socioeconomic status affects the relationship between secondhand smoke exposure and lung disease severity, and whether specific gene-environment interactions influence the effect of secondhand smoke exposure on lung function. Design, Setting, and ParticipantsRetrospective assessment of lung function, stratified by environmental and genetic factors. Data were collected by the US Cystic Fibrosis Twin and Sibling Study with missing data supplemented by the Cystic Fibrosis Foundation Data Registry. All participants were diagnosed with CF, were recruited between October 2000 and October 2006, and were primarily from the United States.Main Outcome Measures Disease-specific cross-sectional and longitudinal measures of lung function. ResultsOf 812 participants with data on secondhand smoke in the home, 188 (23.2%) were exposed. Of 780 participants with data on active maternal smoking during gestation, 129 (16.5%) were exposed. Secondhand smoke exposure in the home was associated with significantly lower cross-sectional (9.8 percentile point decrease; PϽ.001) and longitudinal lung function (6.1 percentile point decrease; P=.007) compared with those not exposed. Regression analysis demonstrated that socioeconomic status did not confound the adverse effect of secondhand smoke exposure on lung function. Interaction between gene variants and secondhand smoke exposure resulted in significant percentile point decreases in lung function, namely in CFTR non-⌬F508 homozygotes (12.8 percentile point decrease; P=.001), TGF␤1−509 TT homozygotes (22.7 percentile point decrease; P=.006), and TGF␤1 codon 10 CC homozygotes (20.3 percentile point decrease; P=.005).Conclusions Any exposure to secondhand smoke adversely affects both crosssectional and longitudinal measures of lung function in individuals with CF. Variations in the gene that causes CF (CFTR) and a CF-modifier gene (TGF␤1) amplify the negative effects of secondhand smoke exposure.

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Section: Commentmentioning

confidence: 89%

Section: Commentmentioning

confidence: 99%

mentioning

confidence: 99%

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Interactions Between Secondhand Smoke and Genes That Affect Cystic Fibrosis Lung Disease

Collaco¹,

Vanscoy²,

Bremer³

et al. 2008

JAMA

133

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“…Others have described cross-sectional (23)(24)(25)(26)(27) and longitudinal associations (18) between lower lung function and second-hand smoke exposure, but the effect of maternal smoking during pregnancy on lung function in children with CF has not to our knowledge been examined elsewhere. The effect of maternal smoking during pregnancy has been shown to be associated with lower lung function in healthy infants and adolescents and more symptoms in young children with asthma (28)(29)(30).…”

Section: Original Researchmentioning

confidence: 99%

Early Childhood Risk Factors for Decreased FEV₁at Age 6-7 Years in Young Children with Cystic Fibrosis

et al. 2015

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Rationale: There are limited objective measures of the severity of lung disease before children are able to routinely perform spirometry, generally at age 6 years. Identifying risk factors for reduced lung function at age 6 provides opportunities to intervene and slow the progression of cystic fibrosis (CF) lung disease.Objectives: To evaluate early childhood predictors of lung function at age 6-7 in a large U.S. CF cohort in the current era of widespread early eradication therapy for Pseudomonas aeruginosa (P. aeruginosa).Methods: Participants were children with CF enrolled before age 4 in the Early Pseudomonas Infection Control (EPIC) Observational Study, a multicenter, longitudinal study that enrolled P. aeruginosa-negative children not exceeding 12 years of age. Linear regression was used to estimate the association between potential early childhood risk factors and the best FEV 1 % predicted at age 6-7 years.Measurements and Main Results: Four hundred and eightyfour children (of 1,797 enrolled in the EPIC Observational Study) met the eligibility criteria for this analysis. Mean (SD) age at enrollment was 2.0 (1.3) years. In a multivariable model adjusted for age at enrollment, the following risk factors were significantly associated with lower mean (95% confidence interval) FEV 1 % predicted at age 6-7: weight percentile less than 10% during the year of enrollment (-5.3 [-9.1, -1.5]), P. aeruginosa positive during the year of enrollment (-2. Conclusions:In this large U.S. cohort, we identified several early childhood risk factors for lower FEV 1 at age 6-7 years, most of which are modifiable. Clinical trial registered with www.clinicaltrials.gov (NCT00097773).Keywords: cystic fibrosis; lung function; microbiology; tobacco smoke pollution Correspondence and requests for reprints should be addressed to Don B. Sanders, M.D., M.S.,

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“…Enfin, il est établi aujourd'hui que le tabagisme passif chez l'enfant peut aggraver certaines maladies respiratoires chroniques telles que la mucoviscidose [14].…”

Section: Tabagisme Chez Le Nourrisson Et L'enfant : Quelles Conséquenunclassified

Cotinine en pédiatrie et en santé au travail

Hoizey

Labat

2009

Ann Toxicol Anal

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Passive smoking and impaired lung function in cystic fibrosis.

Cited by 62 publications

References 4 publications

Interactions Between Secondhand Smoke and Genes That Affect Cystic Fibrosis Lung Disease

Interactions Between Secondhand Smoke and Genes That Affect Cystic Fibrosis Lung Disease

Early Childhood Risk Factors for Decreased FEV₁at Age 6-7 Years in Young Children with Cystic Fibrosis

Cotinine en pédiatrie et en santé au travail

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Passive smoking and impaired lung function in cystic fibrosis.

Cited by 62 publications

References 4 publications

Interactions Between Secondhand Smoke and Genes That Affect Cystic Fibrosis Lung Disease

Interactions Between Secondhand Smoke and Genes That Affect Cystic Fibrosis Lung Disease

Early Childhood Risk Factors for Decreased FEV1at Age 6-7 Years in Young Children with Cystic Fibrosis

Cotinine en pédiatrie et en santé au travail

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Early Childhood Risk Factors for Decreased FEV₁at Age 6-7 Years in Young Children with Cystic Fibrosis