Passive smoking reduces and vitamin C increases exercise-induced oxidative stress: Does this make passive smoking an anti-oxidant and vitamin C a pro-oxidant stimulus?

Theodorou, Anastasios A.; Paschalis, Vassilis; Kyparos, Antonios; Panayiotou, George; Nikolaidis, Michalis G.

doi:10.1016/j.bbrc.2014.10.042

Cited by 22 publications

(17 citation statements)

References 22 publications

(34 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As an example, the dependence of the exercise-induced change in the activity of Catalase on its initial activity was highly significant ( P < 0.0001) and strong ( R 2 = 0.43). The apparently obvious conclusion is that when the initial OS is high, the physical exercise causes a relatively small increase of the OS and at very high OS, the exercise may even lower it, similar to the results of Theodorou et al [ 46 ]. Unfortunately, this interpretation might be incorrect because the results may be due to the statistical phenomenon commonly designated as “regression toward the mean”; that is, the differences between the consecutive measurements of a given parameter correlate with the basal value [ 47 ].…”

Section: Resultssupporting

confidence: 83%

In Healthy Young Men, a Short Exhaustive Exercise Alters the Oxidative Stress Only Slightly, Independent of the Actual Fitness

Finkler

Hochman

Pinchuk

et al. 2016

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

The aim of the present study was to evaluate the apparent disagreement regarding the effect of a typical cycling progressive exercise, commonly used to assess VO2max, on the kinetics of ex vivo copper induced peroxidation of serum lipids. Thirty-two (32) healthy young men, aged 24–30 years, who do not smoke and do not take any food supplements, participated in the study. Blood was withdrawn from each participant at three time points (before the exercise and 5 minutes and one hour after exercise). Copper induced peroxidation of sera made of the blood samples was monitored by spectrophotometry. For comparison, we also assayed TBARS concentration and the activity of oxidation-related enzymes. The physical exercise resulted in a slight and reversible increase of TBARS and slight changes in the activities of the studied antioxidant enzymes and the lag preceding peroxidation did not change substantially. Most altered parameters returned to baseline level one hour after exercise. Notably, the exercise-induced changes in OS did not correlate with the physical fitness of the subjects, as evaluated in this study (VO2max = 30–60 mL/min/kg). We conclude that in healthy young fit men a short exhaustive exercise alters only slightly the OS, independent of the actual physical fitness.

show abstract

Section: Resultssupporting

confidence: 83%

In Healthy Young Men, a Short Exhaustive Exercise Alters the Oxidative Stress Only Slightly, Independent of the Actual Fitness

Finkler

Hochman

Pinchuk

et al. 2016

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…administration of a pro‐oxidant, antioxidant or RONS inhibitor). In particular, we exploited redox individuality, which is a readily observed phenomenon, but at the same time, widely underappreciated in redox literature . More specifically, we used exercise‐induced oxidative stress levels as a classifier to form three experimental groups, which were subsequently subjected to a 6‐week endurance training protocol.…”

Section: Discussionmentioning

confidence: 99%

Adaptations to endurance training depend on exercise‐induced oxidative stress: exploiting redox interindividual variability

et al. 2017

View full text Add to dashboard Cite

Aim: The aim of this study was to reveal the role of reactive oxygen and nitrogen species (RONS) in exercise adaptations under physiological in vivo conditions and without the interference from other exogenous redox agents (e.g. a pro-oxidant or antioxidant). Methods: We invented a novel methodological set-up that exploited the large redox interindividual variability in exercise responses. More specifically, we used exercise-induced oxidative stress as the 'classifier' measure (i.e. low, moderate and high) and investigated the physiological and redox adaptations after a 6-week endurance training protocol. Results: We demonstrated that the group with the low exercise-induced oxidative stress exhibited the lowest improvements in a battery of classic adaptations to endurance training (VO 2 max, time trial and Wingate test) as well as in a set of redox biomarkers (oxidative stress biomarkers and antioxidants), compared to the high and moderate oxidative stress groups. Conclusion: The findings of this study substantiate, for the first time in a human in vivo physiological context, and in the absence of any exogenous redox manipulation, the vital role of RONS produced during exercise in adaptations. The stratification approach, based on a redox phenotype, implemented in this study could be a useful experimental strategy to reveal the role of RONS and antioxidants in other biological manifestations as well.

show abstract

“…In contrast, antioxidant‐deficient individuals (e.g. owing to malnutrition or environmental factors, such as passive smoking) typically exhibit high resting oxidative stress levels (Theodorou, Paschalis, Kyparos, Panayiotou, & Nikolaidis, ). Hence, antioxidant supplementation reverses this aberrant redox homeostasis (i.e.…”

Section: Discussionmentioning

confidence: 99%

Nicotinamide riboside supplementation dysregulates redox and energy metabolism in rats: Implications for exercise performance

Kourtzidis

Dolopikou

Tsiftsis

et al. 2018

Experimental Physiology

View full text Add to dashboard Cite

Nicotinamide riboside is a recently discovered form of vitamin B that can increase NAD(P) levels. NAD(P) plays key roles in energy metabolism, and its main function is the transfer of electrons in various cellular reactions. Research in aged or diseased mice reported that nicotinamide riboside increases NAD(H) levels, reduces morbidity and improves health and muscle function. We have recently shown that in healthy young rats, chronic administration of nicotinamide riboside marginally non-significantly decreased exercise performance by 35% (P = 0.071). As a follow-up to this finding, we analysed samples from these animals, in an attempt to reveal the potential mechanisms driving this adverse effect, focusing on redox homeostasis and bioenergetics. Thirty-eight Wistar rats were divided into four groups: control (n = 10), exercise (n = 9), nicotinamide riboside (n = 10) and exercise plus nicotinamide riboside (n = 9). Nicotinamide riboside was administered for 21 days [300 mg (kg body weight) daily]. At the end of administration, the exercise and the exercise plus nicotinamide riboside groups performed an incremental swimming performance test until exhaustion. Nicotinamide riboside supplementation increased the levels of NADPH in the liver (P = 0.050), increased the levels of F -isoprostanes in plasma (P = 0.047), decreased the activity of glutathione peroxidase (P = 0.017), glutathione reductase (P < 0.001) and catalase (P = 0.024) in erythrocytes, increased the level of glycogen in the liver (P < 0.001) and decreased the concentration of glucose (P = 0.016) and maximal lactate accumulation in plasma (P = 0.084). These findings support the prevailing idea that exogenously administered redox agents in heathy populations might lead to adverse effects and not necessarily to beneficial or neutral effects.

show abstract

Passive smoking reduces and vitamin C increases exercise-induced oxidative stress: Does this make passive smoking an anti-oxidant and vitamin C a pro-oxidant stimulus?

Cited by 22 publications

References 22 publications

In Healthy Young Men, a Short Exhaustive Exercise Alters the Oxidative Stress Only Slightly, Independent of the Actual Fitness

In Healthy Young Men, a Short Exhaustive Exercise Alters the Oxidative Stress Only Slightly, Independent of the Actual Fitness

Adaptations to endurance training depend on exercise‐induced oxidative stress: exploiting redox interindividual variability

Nicotinamide riboside supplementation dysregulates redox and energy metabolism in rats: Implications for exercise performance

Contact Info

Product

Resources

About