Passive Transfer of Tuberculin Sensitivity in the Guinea Pig

Cummings, Martin M.; Hoyt, Martha; Gottshall, R. Y.

doi:10.2307/4586191

Cited by 32 publications

(7 citation statements)

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“…Total body irradiation of 550 R was sufficient to damage or kill enough host lymphoid cells so that infiltration of mononuclear cells at the injection site did not occur. A similar depression of passively transferred delayed hypersensitivity by X-irradiation of guinea pigs was described by Cummings et al (16). If the delayed lesion is triggered by an interaction of antigen and a small number of cells with hypersensitivity it should be possible to find significant numbers of labeled sensitized ceils in a test site of irradiated recipients without the corresponding heavy infiltrate of host elements.…”

Section: Delayed Hypersensitivity and High Affinity Antibodysupporting

confidence: 66%

Immunologic Competence of Thoracic Duct Cells

Coe

Feldman

Lee

1966

The Journal of Experimental Medicine

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Delayed hypersensitivity was produced in donor Lewis rats by sensitization with soluble protein antigens emulsified in complete Freund's adjuvant. Cells of their thoracic duct lymph were collected for varying periods of time and transferred intravenously to isogenic Lewis recipients. With this model the following conclusions were reached: 1. Delayed hypersensitivity was transferred by thoracic duct cells. 2. The longer the drainage of the thoracic duct, the fewer cells were needed to achieve a successful transfer. With continuing drainage the proportion of small lymphocytes decreased and large cells increased. There was, therefore, a better correlation between successful transfer of delayed hypersensitivity and the number of large cells transfused than between positive skin reactions and transfer of small lymphocytes. 3. Prolonged fistula of the thoracic duct did not diminish the skin reaction of sensitized donors to specific antigen. 4. Delayed hypersensitivity was elicited in recipients 3 wk after transfer of sensitized cells. There was evidence that delayed hypersensitivity was enhanced in recipients, possibly because of prior skin testing. 5. Total body X-irradiation abolished the lesions of passively transferred delayed hypersensitivity. Recovery of positive skin tests was observed 19 to 20 days later. 6. The lesions of delayed hypersensitivity were probably mediated by cells. There was no evidence that a circulating high affinity antibody played a role in this type of immunologic reaction.

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Section: Delayed Hypersensitivity and High Affinity Antibodysupporting

confidence: 66%

Immunologic Competence of Thoracic Duct Cells

Coe

Feldman

Lee

1966

The Journal of Experimental Medicine

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“…Takayanagi (1967) reported the passive transfer of experimental myositis by lymphoid cells. The recipients were irradiated to induce tolerance to the donor cells; such irradiation would normally protect recipients from acquiring hypersensitivity through the inability of their own cells to take part in its production (Cummings et al, 1955). In the present work inbred donor and recipient rats have been used.…”

Section: Discussionmentioning

confidence: 99%

Experimental myositis: The in‐vivo and in‐vitro activity of lymph‐node cells

Currie¹

1971

The Journal of Pathology

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“…Although azathioprine has not been investigated with respect to classical delayed hypersensitivity, it does retard allogenic graft rejection (25). In those instances in which x-ray, adrenal steroids, and the radiomimetie drugs have been studied, they also impair reactivity following passive transfer (24,26,27).…”

Section: Influence Of Therapy On Ddayed Response and Passivementioning

confidence: 99%

“…Delayed hypersensitivity passively transferred to previously irradiated recipient animals is impaired (27). The mechanism of this impairment is not understood but it may represent interference with the non-specific component of the delayed reaction.…”

Section: Influence Of Therapy On Ddayed Response and Passivementioning

confidence: 99%

Immunologic Studies in Human Organ Transplantation

Kirkpatrick

Wilson

Talmage

1964

The Journal of Experimental Medicine

101

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Twenty-eight patients with chronic renal diseases and uremia were investigated with respect to their cutaneous responsiveness to a panel of antigens expected to elicit immediate and delayed hypersensitivity reactions. Compared to a control group, there was a marked decrease in the incidence of responses of both types. Eighteen patients received renal allografts from members of the control group and were available for restudy in the postoperative period prior to the institution of adrenal steroid therapy. Each recipient acquired delayed responsiveness with specificity identical with that of the kidney donor. The donor group was reactive to 49 antigens to which the recipients were non-reactive preoperatively. Postoperatively, 40 of these reactivities were observed in the recipients. This successful demonstration of the transfer of immunologically competent tissue in association with renal transplantation indicates that the cause of depressed cutaneous hypersensitivity in uremia is not an inability of the skin per se to react.

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Passive Transfer of Tuberculin Sensitivity in the Guinea Pig

Cited by 32 publications

References 0 publications

Immunologic Competence of Thoracic Duct Cells

Immunologic Competence of Thoracic Duct Cells

Experimental myositis: The in‐vivo and in‐vitro activity of lymph‐node cells

Immunologic Studies in Human Organ Transplantation

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