To improve the performance and reduce the vibration of the mistuned blisk, a novel approach combining the hard-coating and multi-packets is presented. Firstly, the dynamical models of the blisk without hard-coating and multi-packets, the hard-coated mistuned blisk without multi-packets, and the hard-coated mistuned blisk with multi-packets, are established based on the lumped parameter model (LPM). Then, the solved results are compared with that of previous literature to validate the feasibility and correctness of the proposed models. Furthermore, the characteristics of the natural frequencies and the vibration responses for the mistuned blisk are investigated by proposed LPMs. Finally, the effect of the hard-coating and multi-packets on the vibration characteristics for the mistuned blisk are discussed. The obtained results manifest that the vibration response of the mistuned blisk can be further suppressed when the hard-coating and the multi-packets are considered simultaneously compared with only the hard-coating or multi-packets considered, which provides useful guidance on the vibration reduction for the mistuned blisk.