We investigated the relationship of changes in Metabolic syndrome (MetS) and its components with the risk of type 2 diabetes (T2D) in South Korea. Records of 10,806,716 adults aged ≥ 20 years without a history of T2D between 2009 and 2015 were retrieved from database of the South Korean National Health Insurance Service and analyzed. Changes in metabolic components were monitored over a twoyear period with follow-up occurring at an average of 4.087 years. During the follow-up period, 848,859 individuals were diagnosed with T2D. The risk of diabetes was lowered with a decrease in the number of MetS components at baseline and the second visit (p for trend <0.0001). Multivariable-adjusted HRs for incident diabetes were 0.645 among individuals with reduced number of MetS components, 0.54 for those with improvement in elevated fasting glucose, 0.735 for those with improvement in elevated triglycerides, 0.746 for those with improvement in elevated blood pressure, 0.763 for those with improvement in reduced HDL-cholesterol, and 0.92 for those with improvement in abdominal obesity compared with those manifesting them at both time points. In conclusion, changes in metabolic syndrome and its components were significantly associated with the development of T2D. Improvement in MetS and its components attenuated the risk of diabetes. Type 2 diabetes (T2D) is a chronic disease resulting from a complex interaction between heredity and environment, along with other risk factors 1. Insulin resistance, obesity, and behavioral factors such as physical activity, diet, smoking, alcohol consumption, and body weight are important risk factors for T2D 2. Increasing incidence of diabetes and related complications imposes a heavy health burden 3. Thus, investigations should focus on effective interventions and preventive measures for the disease. Metabolic syndrome (MetS) was conceptualized based on a constellation of risk factors, such as elevated fasting plasma glucose (FPG), atherogenic dyslipidemia, elevated blood pressure, and abdominal obesity, in individuals susceptible to cardiovascular disease (CVD) and T2D 4. Guidelines for clinical and epidemiological management of MetS have been developed using readily available clinical variables 5. A number of studies have demonstrated a strong association of MetS and its components with the risk of incident T2D 6-8. Thus, clinical implications of MetS should be focused on multifactorial interventions to reduce the risk of T2D 9. All individuals deserve long-term management of MetS and follow-up in the clinical setting 10. However, cohort studies that correlate the development of T2D with changes in MetS and its components are lacking. Thus, the objective of this nationwide population-based cohort study was to investigate association of changes in MetS and its components with risk of T2D in South Korea.