This brief review identifies seven key science questions in relation to climate variability and change and examines recent research within the Australian and Pacific context: 1. How do the key processes controlling climate variability and predictability operate? 2. What are the nature and causes of regional climate anomalies, past variations in regional climate and extreme weather events and how will they change in the future? 3. How can we provide improved seasonal-to-interannual climate predictions? 4. What are the best projection methods? 5. What are the sea-level changes now and in the future; and how will these impact the coasts? 6. How to have significant benefits on climate service delivery and environmental management? 7. What are the best methods for assessing climate change risks, vulnerability and adaptation options?