2018
DOI: 10.1177/0391398818790343
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Past and future of blood damage modelling in a view of translational research

Abstract: Anatomic pathologies such as stenosed or regurgitating heart valves and artificial organs such as heart assist devices or heart valve prostheses are associated with non-physiological flow. This regime is associated with regions of spatially high-velocity gradients, high-velocity and/or pressure fluctuations as well as neighbouring regions with stagnant flow associated with high residence time. These hemodynamic conditions cause destruction and/or activation of blood components and their accumulation in regions… Show more

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Cited by 17 publications
(27 citation statements)
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“…The described turbulent flow phenomena are universal and therefore occur in every operation point to varying degree in every rotary blood pump, for example, due to the rotor-stator interaction and secondary flow structures. 43 The global contribution of turbulent stresses can be evaluated by analyzing the average hemolysis index MIH from equation (15) in Tables 2 and 3. The deviation between the average hemolysis indices from the mean stresses τ mean (equation (11)) and total stresses < > τ ssr (equation (9b)) is 6.3% and 12.6%.…”
Section: Influence Of Turbulent Stresses On Blood Damage Prediction Rmentioning
confidence: 99%
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“…The described turbulent flow phenomena are universal and therefore occur in every operation point to varying degree in every rotary blood pump, for example, due to the rotor-stator interaction and secondary flow structures. 43 The global contribution of turbulent stresses can be evaluated by analyzing the average hemolysis index MIH from equation (15) in Tables 2 and 3. The deviation between the average hemolysis indices from the mean stresses τ mean (equation (11)) and total stresses < > τ ssr (equation (9b)) is 6.3% and 12.6%.…”
Section: Influence Of Turbulent Stresses On Blood Damage Prediction Rmentioning
confidence: 99%
“…Hence, the stresses from the turbulent field should generally not be disregarded in the numerical damage prediction in a VAD’s flow. 15 , 16…”
Section: Introductionmentioning
confidence: 99%
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“…The potential for advanced numerical models of platelet response to shear magnitude, history and flow dynamics is recommended as a fruitful area of further development. Goubergrits et al 4 present a state-of-thefield assessment with respect to various modelling techniques used in blood trauma. Such modelling is no doubt essential with the continued desire to miniaturize blood pump design, given the associated increase in shear stresses in such constrained geometries.…”
Section: Overview Of Contributionsmentioning
confidence: 99%
“…But, the described numerical blood damage analyses must be performed in such a way that all possible causes of blood damage within the VAD are considered. One of these causes is turbulence, since turbulent vortices inject additional (turbulent) shear stresses to the VAD flow 17 that could additionally damage the blood components 18 …”
Section: Introductionmentioning
confidence: 99%